lithocholic acid

Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM), EphA2 antagonists (IC50=48, 66 μM) and EphB4 antagonists (IC50=141 μM). Lithocholic acid can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is a cleanser that dissolves fat for absorption and is itself absorbed.

N-butyl Lithocholic acid is a derivative of the secondary bile acid lithocholic acid. Lipid nanoparticles containing N-butyl Lithocholic acid and encapsulating mRNA vaccines that express hemagglutinin show reduced cardiotoxicity, splenic, and hepatic toxicity in mice compared to lipid nanoparticles that contain cholesterol.

Lithocholic acid 3-sulfate-D4 disodium isodium is the deuterated form of Lithocholic acid 3-sulfate disodium (TMSM-3220).

Lithocholic acid 3-sulfate disodium (Sulfolithocholic acid disodium) acts as a RORgammat ligand and inhibits Th17 cell differentiation.Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) and induces a decrease in arterial blood pressure. Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) that induces cellular damage.

7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and suppresses the production of endogenous bile acid and the secretion of biliary cholesterol.

Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.

Sulfolithocholic acid is a bioactive chemical.

Taurolithocholic acid 3-sulfate (TLC-S) induces Ca²⁺ signaling in isolated murine pancreatic acinar cells (PACs). Ca²⁺ oscillations occur at concentrations as low as 25 μM and are triggered in nearly all cells at 200 μM. At 300–500 μM, Taurolithocholic produces prolonged Ca²⁺ elevations that begin with intracellular Ca²⁺ release and are sustained by extracellular Ca²⁺ influx. Other bile salts, including taurodeoxycholate (TDC) and taurocholate (TC), can also stimulate local and global Ca²⁺ oscillations but only at much higher concentrations (approximately 1 mM and 5 mM). Taurolithocholic is a potent Ca²⁺-releasing bile acid tested in PACs and is uniquely effective at inducing Ca²⁺-independent ionic currents even at low micromolar levels. Therefore implicating Taurolithocholic as a strong canidate for researches in gut metabolism.

Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.

Lithocholic acid-D5 is the deuterated form of Lithocholic acid. Lithocholic acid (T2202) is a toxic secondary bile acid known to induce intrahepatic cholestasis and promote tumor development.

Isoallolithocholic acid-D4 (3β-Hydroxy-5α-cholanic acid-D4) is a deuterium-labeled form of Isoallolithocholic acid, a derivative of Lithocholic acid. It acts as a T cell modulator by enhancing the differentiation of regulatory T cells (Tregs).

Lithocholic Acid-D4 is a deuterated compound of Lithocholic Acid. Lithocholic Acid (T2202) has a CAS number of 434-13-9. Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

Lithocholic acid (Standard) is a reference standard for research and analysis in studies involving Lithocholic acid. Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a toxic secondary bile acid, They were FXR antagonists (IC50=0.7, 1.4 μM), EphA2 antagonists (IC50=48, 66 μM) and EphB4 antagonists (IC50=141 μM). Lithocholic acid can promote intrahepatic cholestasis and promote tumorigenesis. Lithocholic acid is a cleanser that dissolves fat for absorption and is itself absorbed.

Glycolithocholic acid (Standard) is a reference standard for research and analysis in studies involving Glycolithocholic acid. Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.

Lithocholic acid 3-sulfate disodium (Standard) is a reference standard for research and analysis in studies involving Lithocholic acid 3-sulfate disodium. Lithocholic acid 3-sulfate disodium (Sulfolithocholic acid disodium) acts as a RORgammat ligand and inhibits Th17 cell differentiation.Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) and induces a decrease in arterial blood pressure. Lithocholic acid 3-sulfate disodium is a sulfated product of lithocholic acid (LCA) that induces cellular damage.

Isolithocholic Acid (Standard) is a reference standard for research and analysis in studies involving Isolithocholic Acid. Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.

Lithocholic Acid-D4-3-Sulfate Sodium Salt (Standard) is a reference standard of Lithocholic Acid-[D4]-3-Sulfate Sodium Salt intended for quantitative analysis, quality control, and related biochemical research applications.

Lithocholic Acid-[13C4] (Standard) is a reference standard of Lithocholic Acid-[13C4] intended for quantitative analysis, quality control, and related biochemical research applications.

Lithocholic Acid-[13C3] (Standard) is a reference standard of Lithocholic Acid-[13C3] intended for quantitative analysis, quality control, and related biochemical research applications.

Lithocholic Acid-D4 (Standard) is a reference standard of Lithocholic Acid-D4 intended for quantitative analysis, quality control, and related biochemical research applications. Lithocholic Acid-d4 is a deuterated compound of Lithocholic Acid. Lithocholic Acid has a CAS number of 434-13-9. Lithocholic acid is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.

6-Ketolithocholic acid is a secondary bile acid formed by further microbial metabolism of primary bile acids in the gut. It is suitable for studying bile acid metabolism and exhibits inhibitory activity against glucosyltransferases.

Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a bile acid metabolite and T-cell modulator with anti-inflammatory activity, associated with human immune homeostasis.

Taurolithocholic Acid 3-sulfate sodium salt is a GPR39 agonist. In the absence of Zn²⁺, its EC50 values are 71.6 μM and 69.4 μM in M39-20 and hGPR39-2 cells, respectively; in the presence of Zn²⁺, the values are 9 μM and 9.6 μM, respectively. Taurolithocholic Acid 3-sulfate sodium salt activates the GPR39 receptor and mediates intracellular calcium signaling pathways independently of the Zn²⁺-binding sites H17 and H19, and can be used in research on gallbladder-related diseases.

Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.