lanosterol

Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

Lanosterol-D6 (Standard) is a reference standard of Lanosterol-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Lanosterol-d6 is the deuterated form of Lanosterol. Lanosterol acts as an intermediate in the biosynthesis of cholesterol and can induce the ubiquitination and degradation of HMG-CoA reductase, the rate-controlling enzyme in cholesterol synthesis. Additionally, Lanosterol inhibits the aggregation and cytotoxicity of misfolded proteins linked to neurodegenerative diseases.

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes necessary for ERGOSTEROL synthesis.

Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent

Lanosterol-d6 is the deuterated form of Lanosterol. Lanosterol acts as an intermediate in the biosynthesis of cholesterol and can induce the ubiquitination and degradation of HMG-CoA reductase, the rate-controlling enzyme in cholesterol synthesis. Additionally, Lanosterol inhibits the aggregation and cytotoxicity of misfolded proteins linked to neurodegenerative diseases.

LANOSTEROL (Standard) is a reference standard for research and analysis in studies involving LANOSTEROL. Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

24,25-Dihydrolanosterol (Lanostenol) is a chemical compound found in the seeds of red pepper (Capsicum annuum).

Isomucronulatol 7-O-glucoside is a biologically active isoflavone isolated from Astragalus membranaceus.

Demethyldihydrolanosterol is a type of sterol and a derivative of lanosterol. It is useful for studying cholesterol biosynthesis and for developing drugs targeting cholesterol-related pathways.

Uvariol (21-Hydroxylanosterol), a natural compound, is isolated from the roots of Piptostigma fugax [1].

Azalanstat (RS 21607) is an orally available selective mammalian lanosterol 14-alpha-demethylase inhibitor with hypocholesterolemic activity that inhibits cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes, and hamster livers through inhibition of the cytochrome P450 enzyme, lanosterol 14 alpha demethylase.

Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. This is vital in the cell membrane structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out.

Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Lanomycin, isolated from Pycnidiophora dispersa, inhibits lanosterol 14alpha-demethylase.

SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.

A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity.

Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue.

Lanosteryl acetate is a bioactive chemical.

Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of

BIBB 515 is a selective and potent inhibitor of OSC in vivo with an ED50 value of 0.2-0.5 and 0.36-33.3 mg/kg in rats and mice, respectively. 2, 3-Oxidosqualene cyclase (OSC) is an important enzyme in the biosynthesis of animal, plant, and fungal sterols.

Antifungal agent 40 inhibits C. alb. CYP51 lanosterol 14α-demethylase (CYP51) by extending into the narrow hydrophobic pocket II, thereby affecting biofilm formation.