lanosterol

Lanosterol (3β-Hydroxy-8,24-lanostadiene) is a tetracyclic triterpenoid which is the compound from which all steroids are derived.

Itraconazole (R51211) is a triazole antifungal agent that inhibits cytochrome P-450-dependent enzymes necessary for ERGOSTEROL synthesis.

Butoconazole (1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole) is an imidazole antifungal agent

Lanosterol-D6 is the deuterated form of Lanosterol. Lanosterol (T4970) acts as an intermediate in the biosynthesis of cholesterol and can induce the ubiquitination and degradation of HMG-CoA reductase, the rate-controlling enzyme in cholesterol synthesis. Additionally, Lanosterol (T4970) inhibits the aggregation and cytotoxicity of misfolded proteins linked to neurodegenerative diseases.

Lanosterol (Standard) is the analytical standard of Lanosterol, primarily used for quantitative analysis and metabolic research. Lanosterol is the first sterol intermediate in the cholesterol biosynthetic pathway, synthesized from squalene via squalene epoxidase. It plays a pivotal role in lipid homeostasis by inducing the ubiquitination and proteasomal degradation of HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the pathway. Beyond its metabolic function, Lanosterol exhibits potent molecular chaperone-like activity, inhibiting the aggregation and associated cytotoxicity of misfolded proteins linked to neurodegenerative diseases and cataracts.

Lanosterol-D6 (Standard) is a reference standard of Lanosterol-D6 intended for quantitative analysis, quality control, and related biochemical research applications. Lanosterol-d6 is the deuterated form of Lanosterol. Lanosterol acts as an intermediate in the biosynthesis of cholesterol and can induce the ubiquitination and degradation of HMG-CoA reductase, the rate-controlling enzyme in cholesterol synthesis. Additionally, Lanosterol inhibits the aggregation and cytotoxicity of misfolded proteins linked to neurodegenerative diseases.

24,25-Dihydrolanosterol (Lanostenol) is a chemical compound found in the seeds of the red pepper (Capsicum annuum). 24,25-Dihydrolanosterol (Lanostenol) is therefore utilized in phytosterol and lipidomics research for structural characterization of sterol derivatives in Capsicum annuum seed metabolite profiling systems. 24,25-Dihydrolanosterol (Lanostenol) is also applied in biochemical membrane studies investigating sterol incorporation and lipid bilayer composition in model membrane systems.

Isomucronulatol 7-O-glucoside is a biologically active isoflavone isolated from Astragalus membranaceus.

24(S/R),25-Epoxylanosterol is a type of oxidized cholesterol (Oxysterol).

Demethyldihydrolanosterol is a type of sterol and a derivative of lanosterol. It is useful for studying cholesterol biosynthesis and for developing drugs targeting cholesterol-related pathways.

Uvariol (21-Hydroxylanosterol), a natural compound, is isolated from the roots of Piptostigma fugax [1].

Azalanstat (RS 21607) is an orally available selective mammalian lanosterol 14-alpha-demethylase inhibitor with hypocholesterolemic activity that inhibits cholesterol synthesis in HepG2 cells, human fibroblasts, hamster hepatocytes, and hamster livers through inhibition of the cytochrome P450 enzyme, lanosterol 14 alpha demethylase.

Ketoconazole (R-41400) is an imidazole antifungal agent with broad-spectrum antifungal activity that primarily acts by inhibiting the biosynthesis of ergosterol in the fungal cell membrane. Ketoconazole inhibits the fungal cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51), thereby blocking the conversion of lanosterol to ergosterol. This leads to damage to the cell membrane structure and permeability, consequently inhibiting fungal growth and producing an antifungal effect. In addition, ketoconazole is a non-selective cytochrome P450 (CYP) inhibitor, specifically inhibiting drug-metabolizing enzymes such as human CYP3A4. In terms of endocrinology, ketoconazole also inhibits various enzymes involved in steroid synthesis (CYP17A1, CYP11A1).

Bifonazole (Bay H-4502) acts to destabilize the fungal cytochrome p450 51 enzyme (also known as Lanosterol 14-alpha-demethylase). It works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes. This is vital in the cell membrane structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out.

Butoconazole Nitrate is the nitrate salt form of butoconazole, a synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate (RS 35887) interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butoconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.

Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

Oxiconazole is a broad-spectrum imidazole antifungal agent with fungicidal activity against T. rubrum, T. mentagrophytes, T. tonsurans, T. violaceum, E. floccosum, M. canis, M. audouini, M. gypseum, C. albicans, and M. furfur. have fungicidal activity, inhibiting ergosterol biosynthesis and disrupting fungal cell membrane integrity by disrupting cytochrome P450 enzymes (lanosterol 14- α demethylase). It also inhibits DNA synthesis and suppresses intracellular ATP concentration.

Oxiconazole nitrate (Ro 13-8996) is the nitrate salt form of oxiconazole, a broad-spectrum imidazole derivative with antifungal activity. Likely inhibiting cytochrome P450-dependent demethylation of lanosterol, it prevents ergosterol synthesis, a crucial component of the fungal cell membrane. This disruption of membrane synthesis and integrity alters permeability, promotes loss of essential intracellular components, and inhibits fungal cell growth.

Antifungalagent 136 (Compound M-15) is an irreversible inhibitor of fungal lanosterol 14α-demethylase (CYP51). It exhibits potent antifungal activity against drug-resistant Candida albicans and can downregulate the expression of IL-6. Antifungalagent 136 shows promise for research into fungal infections and inflammatory diseases.

Antifungalagent 137 (Compound 4S) is an antifungal compound that inhibits Phomopsis sp. (PS) with an EC50 value of 0.15 μg/mL. It targets lanosterol 14α-demethylase (CYP51) with an IC50 value of 5.00 μg/mL. Additionally, it disrupts PS mycelial morphology, compromises cell membrane integrity, and increases intracellular ROS levels, inducing oxidative stress. This compound is useful for research on fungal infections.

Lanomycin, isolated from Pycnidiophora dispersa, inhibits lanosterol 14alpha-demethylase.

SK&F 104976 is a 32-carboxylic acid derivative of lanosterol. It was found to be a potent lanosterol 14 alpha-demethylase (14 alpha DM) inhibitor.

A 60586, a non-azole inhibitor of ergosterol biosynthesis, inhibits lanosterol 14alpha-demethylase and displays in-vitro antifungal activity.

Holothurinogenin, as a lanosterol derivative, has toxic to nerve tissue.