iap 6

Q203 (Telacebec) is a novel potent anti-tuberculosis agent targeting cytochrome b subunit qcrB and inhibits M. tuberculosis H37Rv (MIC50: 2.7 nM).

IAP ligand 6 (A250) is an IAP ligand with a binding affinity (Ka) of 0.1 μM to the human XIAPBIR3 domain. It can bind to the XIAPBIR3 domain and serves as an alkynyl pyridine scaffold for developing TEAD degraders that recruit IAP. IAP ligand 6 is applicable in mesothelioma-related research.

cIAP1 Ligand-Linker Conjugates 6 hydrochloride combines an IAP ligand for the E3 ubiquitin ligase with a PROTAC linker, and is utilized for designing SNIPERs[1].

K-Rasligand-Linker Conjugate 6 formate includes a target protein K-Ras ligand (K-Ras recruitment motif) and a PROTAC linker, capable of recruiting E3 ligases such as VHL, CRBN, MDM2, and IAP. It is utilized in synthesizing PROTACK-Ras Degrader-1, a potent PROTACK-Ras degrader, achieving a K-Ras degradation rate of ≥70% in SW1573.

BV6 is an antagonist of c-IAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.