hydrolytic

KT203, a selective and potent structural domain 6 (ABHD6) inhibitor of alpha beta hydrolytic enzymes, exhibits potential antiviral and anti-inflammatory properties for pneumonia research.

Laromustine (VNP40101M) is a sulfonyl hydrolytic alkylating prodrug used in cancer therapy with significant anticancer activity. Inhibiting thioredoxin reductase can be used to study acute myeloid leukemia.

Gabexate mesylate (FOY) is a serine proteinase inhibitor used therapeutically in the treatment of pancreatitis, disseminated intravascular coagulation (DIC), and as a regional anticoagulant for hemodialysis. The drug inhibits the hydrolytic effects of thrombin, plasmin, and kallikrein, but not of chymotrypsin and aprotinin.

Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.

Rebaudioside D is a potential sweetener. Rebaudioside D shows similar stability when exposed to simulate stomach and small intestine fluids, with susceptibility to hydrolytic degradation by enteric bacteria collected from the cecum.

Naringinase is a hydrolytic enzymatic complex that exhibits α-L-rhamnosidase and β-D-glucosidase activities. It is widely found in nature and is primarily utilized for the biotransformation of steroids, antibiotics, and glycosides.

PF04677490 is an effective PDE1 inhibitor. PF04677490 efficaciously inhibits cAMP- and cGMP-hydrolytic activity in preparations from human myocardium at concentrations selective for PDE1.

N-Phthaloylglutamic acid is a hydrolytic metabolite of thalidomide.

Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase.

ERAP2-IN-1 (compound 61) is a non-competitive inhibitor of ERAP2 that specifically inhibits its hydrolytic activity, with an IC50 of 27 μM for Arg-AMC hydrolysis and an IC50 of 44 μM for model peptide hydrolysis.

Arginase (L-Arginine amidinase) is a key hydrolytic enzyme in the urea cycle, which hydrolyzes L-arginine into urea and L-ornithine. Arginase can be used for cancer research.

Phenyl-glutarimide 4'-piperazine, a piperazine-functionalized cereblon ligand, facilitates the development of PG-PROTACs with enhanced hydrolytic stability and potency compared to those produced with IMiD (immunomodulatory imide drug) analogs. It serves as a foundation for PROTACDegrader development.

Prostaglandin E1 (PGE1), synthesized through cyclooxygenase-mediated metabolism of dihomo-γ-linolenic acid (DGLA), functions by inhibiting platelet aggregation (IC50= 40 nM) and enhancing vasodilation. Its analog, 13,14-dihydro-16,16-difluoro PGE1, and the metabolite, 13,14-dihydro PGE1, both retain similar anti-aggregatory properties to the original compound. The inclusion of two electron-withdrawing fluorine atoms in 13,14-dihydro-16,16-difluoro PGE1 is believed to increase molecular stability and potentially extend bioavailability by resisting hydrolytic degradation.

Arachidoyl ethanolamide, a saturated fatty acyl ethanolamide lacking classical (CB1 CB2) activity, plays a role in a complex system comprising central cannabinoid (CB1), peripheral cannabinoid (CB2), and non-CB receptor-mediated pharmacology. This system has paved the way for extensive research in diverse fields such as memory, weight loss and appetite, neurodegeneration, tumor surveillance, analgesia, and inflammation. Unlike other compounds, Arachidoyl ethanolamide does not bind to the murine CB1 receptor nor does it compete with anandamide for the fatty acid amide hydrolase, the endocannabinoid hydrolytic enzyme. The non-CB receptor-mediated actions of saturated ethanolamides like Arachidoyl ethanolamide are currently under investigation.

Phenyl-glutarimide 4'-oxyacetic acid, a carboxylic acid-functionalized cerebellar ligand, is utilized in developing PROTAC deactivators due to its superior hydrolytic stability and efficacy. This compound exhibits enhanced binding to PROTAC, [1].

(3R,5R)-Rosuvastatin, a potential impurity detected in bulk rosuvastatin formulations, arises as a degradation product through various stresses including acid or base hydrolysis, thermal, photolytic, hydrolytic, oxidative stress, or during storage. This compound is associated with the HMG-CoA reductase inhibitor class to which rosuvastatin belongs.

6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.

5,6-DM-cBIMP, a cyclic nucleotide analog, acts as a PDE2 agonist, significantly enhancing the hydrolytic activity of PDE2 on cAMP and cGMP.

Polyvinyl alcohol (Mw 85000-124000, 87-89% hydrolyzed) is a polymer with a molecular weight of 85000-124000, known for its hydrolytic properties. The degree of hydrolysis indicates the conversion rate of acetate groups into hydroxyl groups from the original polyvinyl acetate. Polyvinyl alcohol is produced through the polymerization of vinyl acetate, followed by the hydrolysis that removes acetate groups, resulting in the formation of polyvinyl alcohol. An 87-89% degree of hydrolysis demonstrates the significant removal of acetate groups, creating a substantial number of hydroxyl groups within the PVA structure. Polyvinyl alcohol with different degrees of hydrolysis can form self-crosslinked cryogels, used as bio-auxiliary materials.

PVA (Mw 67000, 87-89% hydrolyzed, ～1400 polymerization) is a form of polyvinyl alcohol with a molecular weight of 67000 and hydrolytic properties. The degree of hydrolysis indicates the rate at which acetate groups in the original polyvinyl acetate are converted to hydroxyl groups. This PVA is obtained by polymerizing vinyl acetate and subsequently removing the acetate groups through hydrolysis. Polyvinyl alcohols with varying degrees of hydrolysis can be used in self-crosslinking to form freeze gels, which are utilized as biological excipients.

PLLA5000-PEG5000-Thiol is a polylactic acid derivative capable of forming micelles in water. It undergoes biodegradation through the hydrolytic cleavage of ester bonds. Additionally, PLLA5000-PEG5000-Thiol is applicable in drug delivery research.

PLLA5000-PEG3000-Thiol is a polylactic acid derivative that forms micelles in water and undergoes biodegradation through hydrolytic ester bond cleavage. It is applicable in research focused on drug delivery.

PLLA5000-PEG1000-Thiol is a polylactic acid derivative capable of forming micelles in aqueous solutions, and it undergoes biodegradation through hydrolytic cleavage of ester bonds. PLLA5000-PEG1000-Thiol is utilized in drug delivery research.

PLLA4000-PEG5000-Thiol is a polylactic acid derivative that can form micelles in water and undergoes biodegradation through hydrolytic attack on ester bonds. It is applicable in drug delivery research.