hne

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

BAY-85-8501 is a selective, reversible, and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM.

Midesteine (MR-889) is a small molecule neutrophil elastase inhibitor used in the treatment of bronchitis, asthma and chronic lung disease.

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.

Daphnenone is a natural product that can be used as a reference standard.

Daphneolone is a natural product that can be used as a reference standard.

Daphnezomine B is a useful organic compound for research related to life sciences and the catalog number is T125212.

Daphnetin 8-O-glucoside is a useful organic compound for research related to life sciences and the catalog number is T125379.

Daphnelantoxin B is a useful organic compound for research related to life sciences and the catalog number is T126019.

Lochnerine is an alkaloid of terpenoid indole.

Lochnericine is a alkaloid isolated from elicited cell cultures of Catharanthus roseus.

Lochneridine is a bioactive chemical.

Daphnegiravone D (compound 70) is an inhibitor of HDAC6, exhibiting anti-hepatocellular carcinoma activity. It induces apoptosis and selectively inhibits the proliferation of liver cancer cells via the p38 and JNK MAPK pathways.

4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.

daphneticin is a natural product.

Lodelaben (Declaben, SC-39026) is a reversible, non-competitive inhibitor of human neutrophil elastase (HNE), characterized by specificity and potency (IC50=0.5 μM, Ki=1.5 μM).

4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

BAY-677, serving as an inactive control for BAY-678, is distinguished by BAY-678's capabilities as an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE), showcasing a high potency with an IC50 of 20 nM[1]. Furthermore, BAY-678 has been publicly nominated as a chemical probe by the Structural Genomics Consortium (SGC)[2].

(R)-BAY-85-8501 is the less active enantiomer of BAY-85-8501, a selective and potent Human Neutrophil Elastase (HNE) inhibitor with an IC50 of 65 pM.

BAY-678 racemate is a racemate of BAY-678, an orally bioavailable, selective, and cell-permeable inhibitor of human neutrophil elastase (HNE; IC50: 20 nM).

MeO-Suc-Ala-Ala-Pro-Ala-CMK (MSACK) is an inhibitor of human neutrophil elastase (HNE) with an IC50 of 20.3 μM. It effectively inhibits the hydrolysis of substrates like lung tissue elastin by HNE and is applicable in studies related to conditions such as chronic obstructive pulmonary disease (COPD).

Neutrophilelastase inhibitor 5 (Compound 29) acts as a dual inhibitor of HNE (human neutrophil elastase) and protease 3 (PR3), with IC50 values of 4.91 μM and 20.69 μM, respectively. Neutrophilelastase inhibitor 5 is applicable for research in neutrophil inflammatory diseases.