hne

BAY-678 is a human neutrophil elastase (HNE; IC50: 20 nM) inhibitor with oral bioactivity, potency and selectivity.BAY-678 is a chemical probe recommended by the Structural Genomics Consortium (SGC).

GW-311616 hydrochloride is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

GW-311616 is a long duration, orally bioavailable, and selective human neutrophil elastase (HNE) inhibitor (IC50: 22 nM; Ki: 0.31 nM).

BAY-85-8501 is a selective, reversible, and potent inhibitor of Human Neutrophil Elastase (HNE) with an IC50 of 65 pM.

4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).

4-Hydroxynonenal-BSA is a hapten-carrier protein conjugate formed by coupling 4-Hydroxynonenal to bovine serum albumin (BSA). As a hapten, 4-Hydroxynonenal alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. 4-Hydroxynonenal-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

4-Hydroxy nonenal glutathione (4-HNE-GSH) TFA is the primary metabolite of 4-hydroxy-2-nonenal. It serves as a marker for oxidative stress in rat liver and hepatocytes. Additionally, 4-Hydroxy nonenal glutathione TFA effectively prevents the formation of 4-hydroxy-2-nonenal-DNA adducts in human cells.

4-HNE-Dimethylacetal, an α,β-unsaturated hydroxy aldehyde, can be produced through intracellular lipid peroxidation. It is useful for researching cell signaling pathways, ranging from cell cycle events to cell adhesion.

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.

Daphnenone is a natural product that can be used as a reference standard.

Daphneolone is a natural product that can be used as a reference standard.

Daphnezomine B is a useful organic compound for research related to life sciences and the catalog number is T125212.

Daphnetin 8-O-glucoside is a useful organic compound for research related to life sciences and the catalog number is T125379.

Daphnelantoxin B is a useful organic compound for research related to life sciences and the catalog number is T126019.

Lochnerine is an alkaloid of terpenoid indole.

Lochnericine is a alkaloid isolated from elicited cell cultures of Catharanthus roseus.

Lochneridine is a bioactive chemical.

Daphnegiravone D (compound 70) is an inhibitor of HDAC6, exhibiting anti-hepatocellular carcinoma activity. It induces apoptosis and selectively inhibits the proliferation of liver cancer cells via the p38 and JNK MAPK pathways.

4-Methyldaphnetin (DHMC) is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin(7,8-Dihydroxy-4-methylcoumarin) inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.

Daphnetin (Standard) is a reference standard for research and analysis in studies involving Daphnetin. Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM), and PKC (IC50: 25.01 μM), also exhibit anti-oxidant and anti-inflammatory activities.

daphneticin is a natural product.

Chembridge-5861528 (TCS 5861528) is a TRPA1 channel blocker that inhibits AITC- and 4-HNE-induced calcium influx with IC50 values of 14.3 μM and 18.7 μM, respectively.

Epimedokoreanin B (EKB), an isoprenylated flavonoid isolated from Korean Epimedium, exhibited anticancer activity in human non-small cell lung cancer (NSCLC) A549 and NCI-H292 cells.Epimedokoreanin B also possesses anti-inflammatory and antibacterial activities, and may have scavenging activity against DPPH radicals, inhibiting the proliferation of MCF-7 and HepG2 in a dose-dependent manner. Epimedokoreanin B also exhibits anti-inflammatory and antibacterial activity, with DPPH radical scavenging activity, and inhibits the proliferation of MCF-7 and HepG2 in a dose-dependent manner.Epimedokoreanin B significantly inhibits the formation of N (α)-(carboxymethyl)lysine (CML) and N (Ï)-(carboxymethyl)arginine (CMA), and prevents clinical complications of diabetes mellitus through the inhibition of advanced glycation end-products (AGEs).

NSC 694621 is a PCAF and histone acetyltransferase (HAT) inhibitor that forms a covalent bond with Cys574, the active site of PCAF, thereby irreversibly inhibiting its acetyltransferase activity, and is able to inhibit the proliferation of SK-N-SH and HCT116 cells, which has anticancer potential.