hbs

Voxelotor (GBT 440) is a novel hemoglobin S (HbS) polymerization inhibitor primarily used for the treatment of sickle cell disease (SCD) and a cytochrome P450 3A4 inhibitor. Voxelotor targets and covalently binds to the N-terminal valine of the HbS alpha chain, thereby stabilizing sickle cell hemoglobin (HbS).

Aβ1-14-εK-HBsAg3 Th (UB311 immunogen II) is a bioactive peptide. It is one of the Aβ1–14 targeting peptides (B cell epitope) for UB-311.

HBF-0259 is an inhibitors of hepatitis B virus surface antigen (HBsAg) secretion with an EC50 of 11.3 μM and a CC50 value of >50 μM in HepG2.2.15 cells. HBF-0259 had a EC50 of approximately 1.5 microM in a secondary, HBV-expressing cell line, with a concentration that exhibited 50% cytotoxicity of >50 microM. The equilibrium concentration of HBF-0259 in aqueous solution at physiological pH was 15 to 16 microM; the selective index was thus >9.

RG7834 (RO 7020322) is a highly selective and orally bioavailable inhibitor of HBV, targeting HBsAg, HBeAg, and HBV DNA with IC50s of 2.8 nM, 2.6 nM, and 3.2 nM, respectively, in dHepaRG Cells.

BzNH-BS is a chemical compound comprising two distinct ligands: methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide. The ligands are interconnected through linkers. MeBS functions as a ligand for cIAP1, a ubiquitin ligase involved in cellular inhibition of apoptosis processes [1].

AS1517499 is a blood-brain barrier permeable inhibitor of STAT6 phosphorylation (IC50= 21 nM).

Oleana-2,12-dien-28-oic acid is an HBsAg and HBeAg inhibitor that significantly inhibits HBV deoxyribonucleic acid (HBV-DNA) replication in HepG2.2.15 cells, making it relevant for the study of hepatitis B virus infection.

Chamaechromone is a natural product isolated from the roots of Stellera chamaejasme L.. Chamaechromone has anti-HBV and insecticidal activity.

Hank's Balanced Salt Solution (Ca2+, Mg2+, No phenol red) is a classic isotonic buffer solution suitable for cell cleaning, pretreatment of trypsin digestion, and short-term storage and transfer of cells. This product supplements Ca2+ and Mg2+ on the basis of the classic HBSS formula, providing the basic ion environment and osmotic pressure support required by cells. The ingredients include 137.93 mM NaCl, 5.33 mM KCl, 4.17 mM NaHCO3, 0.441 mM KH2PO4, 0.338 mM Na2HPO4, 5.56 mM D-Glucose, 1.26 mM CaCl2, 0.493 mM MgCl2, 0.407 mM MgSO4, and is free of phenol red.

Isoniazid-BSA is a hapten-carrier protein conjugate formed by binding isoniazid to BSA (bovine serum albumin). It enhances isoniazid-induced immune responses by combining a hapten with a protein adjuvant, commonly used in vaccine or antibody preparation research.

Osivelotor is an allosteric modulator of hemoglobin S (HbS) [1].

PF-07059013, an orally active and potent noncovalent modulator of sickled hemoglobin (HbS), specifically binds to Hb with nanomolar affinity and demonstrates substantial partitioning into red blood cells (RBCs), making it useful for sickle cell disease (SCD) research [1][2].