endometriosis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27837	Linzagolix		GNRH Receptor
	Linzagolix is a small-molecule, non-peptide, orally active gonadotropin-releasing hormone antagonist (GnRH antagonist) which is under development by Kissei Pharmaceutical and ObsEva for the treatment of uterine fibroids,...		GNRH Receptor
T2577	Dienogest	STS 557	Apoptosis , Estrogen/progestogen Receptor , Progesterone Receptor , Autophagy
	Dienogest (STS 557) is an orally-active, semisynthetic, fourth generation, nonethinylated progestogen with antiproliferative, antiandrogenic, anti-inflammatory and antiangiogenic activities that is used in hormone therap...
T3630	Relugolix	RVT-601,TAK-385	GNRH Receptor
	Relugolix (RVT-601) is an orally available, non-peptide gonadotropin-releasing hormone (GnRH or luteinizing hormone-releasing hormone (LHRH)) antagonist, with potential antineoplastic activity. Relugolix competitively bi...		GNRH Receptor
T21308	Histrelin	Supprelin LA,Histrelin Acetate	Others
	Histrelin (Supprelin LA) acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of th...		Others
T27267	ENMD-1068 HCl	ENMD-1068 HCl,ENMD 1068,ENMD-1068,ENMD1068,ENMD-1068 hydrochloride	Protease-activated Receptor
	ENMD-1068 HCl (ENMD 1068) is a PAR-2 antagonist. ENMD-1068 HCl inhibits the development of endometriosis in a mouse model.		Protease-activated Receptor
T28362	PF-02413873	PF02413873	Progesterone Receptor
	PF-02413873 is a competitive antagonist of nonsteroidal progesterone receptor with a Ki of 2.6 nM. PF-02413873 can be used in studies about the treatment of gynecological conditions such as endometriosis.		Progesterone Receptor
T1514	Norethindrone	Norethisterone	Estrogen/progestogen Receptor , Progesterone Receptor
	Norethindrone (Norethisterone) is a synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties...		Estrogen/progestogen Receptor , Progesterone Receptor
T25742	Linzagolix choline		GNRH Receptor
	Linzagolix choline is an orally available non-peptide gonadotropin-releasing hormone (GnRH) antagonist. It can be used to study pain associated with uterine fibroids and endometriosis.		GNRH Receptor
T40598	Norethindrone acetate	19-Norethindroneacetate	Estrogen Receptor/ERR , Progesterone Receptor
	Norethindrone acetate (19-Norethindroneacetate) is an oestrogen with inhibitory effects on adolescent menstruation and hepatic adenomas and is often used in combination with progestins in the study of endometriosis.		Estrogen Receptor/ERR , Progesterone Receptor
T37003	GnRH antagonist 2
	GnRH antagonist 2 (formula I) is a potent GnRH receptor antagonist with valuable applications in endometriosis research[1].
T32684	Leuprolide (1-3)	Leuprorelin
	Leuprolide (1-3) is a manufactured version of a hormone used to treat prostate cancer, breast cancer, endometriosis, uterine fibroids, and early puberty.
T62237	Steroid sulfatase-IN-4
	Steroid sulfatase-IN-4 (Compound 16) is an irreversible inhibitor of steroid sulfatase (STS) that acts on human STS (IC50: 25 nM). steroid sulfatase-IN-4 can be used to study endometriosis.
T0171	Norethynodrel	Lynestrol	Estrogen/progestogen Receptor
	Norethynodrel (Lynestrol) is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contracepti...		Estrogen/progestogen Receptor
T81092	Steroid sulfatase/17β-HSD1-IN-5
	Steroid sulfatase/17β-HSD1-IN-5 serves as an irreversible inhibitor of steroid sulfatase (STS) and a reversible, selective inhibitor of 7β-hydroxysteroid dehydrogenase type1 (17β-HSD1), exhibiting IC50 values of 43 nM fo...
T71149	Triptorelin pamoate
	Triptorelin, a decapeptide (pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2), is a gonadotropin-releasing hormone agonist (GnRH agonist) used as the acetate or pamoate salts. By causing constant stimulation of the pituita...
T60854	ENMD-1068 hydrochloride
	ENMD-1068 hydrochloride, a selective protease-activated receptor 2 (PAR2) antagonist, inhibits TGF-β1/Smad signaling, thereby reducing hepatic stellate cell activation and collagen expression. It also suppresses the prol...
T62236	Steroid sulfatase/17β-HSD1-IN-3
	Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 can be used to study endometriosis and ...
T61979	Steroid sulfatase/17β-HSD1-IN-4
	Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a potent dual inhibitor of steroid sulfatase ( STS ) and 17β-hydroxysteroid dehydrogenase type 1 ( 17β HSD1 ). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS a...
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antag...
T68525	Nafarelin acetate hydrate
	Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estroge...