deacetylases — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T1819	Nexturastat A		HDAC
	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.		HDAC
T6327	Tubacin		Virus Protease , HDAC
	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.		Virus Protease , HDAC
T7664	Pyroxamide		Apoptosis , HDAC
	Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).		Apoptosis , HDAC
T16129	MPI_5a		HDAC
	MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).		HDAC
T9745	Elevenostat		HDAC
	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.		HDAC
T5830	SKLB-23bb		HDAC
	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.		HDAC
TQ0207	Sulforaphane		Apoptosis , Nrf2 , HDAC
	Sulforaphane is derived from the consumption of cruciferous vegetables, such as broccoli. It has shown anticancer and cardioprotective activities.		Apoptosis , Nrf2 , HDAC
T5631	SIS17		HDAC
	SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhib...		HDAC
T1857	TMP269		HDAC
	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectively.		HDAC
T5332	TH34		HDAC
	TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.		HDAC
T3205	UF010		HDAC
	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.		HDAC
T16962	SW-100		HDAC
	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the...		HDAC
T3206	NKL 22	Histone Deacetylase Inhibitor IV,PAOA	HDAC
	NKL 22 (Histone Deacetylase Inhibitor IV) is an effective Histone Deacetylase Inhibitor.		HDAC
T7385	WT-161		Apoptosis , HDAC
	WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).		Apoptosis , HDAC
T7082	HDAC8-IN-1		HDAC
	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cancer cell lines (A549, H1299, and CL1-5). HDAC8-IN-1 exhibits ...		HDAC
T2430	HPOB		Apoptosis , HDAC
	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.		Apoptosis , HDAC
T6061	LMK-235	LMK235	HDAC
	LMK-235 is a potent HDAC inhibitor, and is used in cancer research.		HDAC
T3358	ITSA-1	ITSA1	HDAC
	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.		HDAC
T1762	RGFP966	RGFP 966	HDAC
	RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM.		HDAC
T3509	ACY-738	ACY 738	HDAC
	ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.		HDAC