dbco-nhs ester

DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

DBCO-NHS ester 2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and is a Dibenzylcyclooctyne (DBCO) derivative designed for copper-free click chemistry [1].

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azido group. The DBCO group, known for its strain-promoted high energy, is typically used in copper-free click chemistry reactions. The NHS ester can react with amino acids or other molecules containing amino groups.

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.

Azido-PEG4-NHS-ester is a PEG-based linker molecule that can be used as a linker in PROTAC construction. It contains an azide group that participates in click chemistry reactions, including copper-catalyzed azide–alkyne cycloaddition (CuAAC) with alkynes, as well as strain-promoted azide–alkyne cycloaddition (SPAAC) with DBCO or BCN groups, thereby enabling molecular conjugation.

DBCO-acid is utilized in the synthesis of ADC linker DBCO-NHS ester and drug-linker conjugates DBCO-PEG-MMAE[1].

DBCO-NHCO-PEG4-NHS ester is a DBCO-containing PEGylated active ester linker that combines NHS ester reactivity toward primary amines with strain-promoted azide-alkyne cycloaddition capability. It enables efficient bioconjugation through amide coupling and copper-free click reaction with azide groups. The PEG4 spacer provides hydrophilicity and tunable linker length, making it widely used in PROTAC and antibody-drug conjugate (ADC) construction.

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

DBCO-PEG5-NHS ester is a PROTAC linker belonging to the PEG and Alkyl/ether classes for the synthesis of a range of PROTAC molecules.

DBCO-Sulfo-NHS ester sodium is a degradable ADC linker that can be used to synthesize ADC compounds.

DBCO-CONH-S-S-NHS ester is a disulfide-linked ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NH-PEG7-C2-NHS ester is a polyethylene glycol (PEG) derived linker with a terminal DBCO moiety, functioning as an N-hydroxysuccinimide (NHS) ester, and suitable for the efficient synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-NHCO-C4-NHS ester, an alkyl chain-derived PROTAC linker, is used for PROTAC synthesis[1].

DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis [1].

DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

DBCO-NHCO-S-S-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose DBCO group undergoes click chemistry with azide-containing molecules.

DBCO-PEG8-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

N-DBCO-N-bis(PEG2-C2-NHS ester) is a PEG-like PROTAC linker that can be used to synthesize PROTAC molecules, and also contains a DBCO moiety for click chemistry with azide groups.

Azido-PEG36-NHS ester is a PROTAC linker belonging to the PEG family, useful in the synthesis of PROTAC molecules. As a click chemistry reagent, it contains an azide group, facilitating copper-catalyzed azide-alkyne cycloaddition reactions (CuAAC) with molecules containing alkyne groups. It also participates in strain-promoted azide-alkyne cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

Azido-PEG7-NHS ester is a PROTAC linker that falls under the PEG category and is used for synthesizing PROTAC molecules. This compound acts as a click chemistry reagent, featuring an Azide group, which can undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an Alkyne group. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) with molecules that contain DBCO or BCN groups.