dbco nhs ester

DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

DBCO-NHS ester 2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and is a Dibenzylcyclooctyne (DBCO) derivative designed for copper-free click chemistry [1].

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azido group. The DBCO group, known for its strain-promoted high energy, is typically used in copper-free click chemistry reactions. The NHS ester can react with amino acids or other molecules containing amino groups.

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

DBCO-Sulfo-NHS ester sodium is a degradable ADC linker that can be used to synthesize ADC compounds.

DBCO-CONH-S-S-NHS ester is a disulfide-linked ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NH-PEG7-C2-NHS ester is a polyethylene glycol (PEG) derived linker with a terminal DBCO moiety, functioning as an N-hydroxysuccinimide (NHS) ester, and suitable for the efficient synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-NHCO-C4-NHS ester, an alkyl chain-derived PROTAC linker, is used for PROTAC synthesis[1].

DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis [1].

DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

DBCO-NHCO-S-S-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose DBCO group undergoes click chemistry with azide-containing molecules.

DBCO-PEG8-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG13-NHS ester is a PEG-type PROTAC linker useful in the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent and contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

PC DBCO-PEG4-NHS ester, a PEG-based linker for PROTACs, connects two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-PEG2-NHS ester is a click chemistry reagent featuring an azide group and an NHS ester, designed for copper-free Click Chemistry. It specifically and efficiently reacts with primary amines (e.g., lysine residue side chains or aminosilane-coated surfaces) under neutral or slightly basic conditions to form stable covalent bonds. The inclusion of a hydrophilic PEG spacer enhances water solubility and provides a flexible linkage, reducing steric hindrance during ligation. This compound, intended for research use only [1], is ideal for applications requiring precise and efficient bioconjugation.

DBCO-PEG24-NHS ester is a click chemistry reagent featuring an NHS ester functionality, allowing for specific and efficient covalent bonding with primary amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or slightly basic conditions. The hydrophilic polyethylene glycol spacer not only enhances solubility in water but also provides a long and flexible linkage that minimizes steric hindrance during the coupling process. Commonly used in copper-free click chemistry, DBCO-PEG24-NHS ester is available for research purposes only.

DBCO-N-bis(PEG4-NHS ester) is a PEG linker equipped with one DBCO moiety and two PEG4-NHS esters. This compound serves as a versatile tool in click chemistry, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing molecules. It is commonly utilized for protein modification or labeling, making it a valuable reagent in biochemical applications.

DBCO-PEG16-NHS ester is a PEG derivative composed of DBCO, PEG units, and an NHS ester. The NHS ester can react with amino acids or other amine-containing molecules. The DBCO group in DBCO-PEG16-NHS ester can engage in a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with azide-containing molecules.

DBCO-PEG6-NHS ester is a PEG reagent with an NHS ester, designed for click chemistry applications. It reacts specifically and efficiently with primary amines, such as lysine side chains or amino silane-coated surfaces, under neutral to slightly basic conditions, forming covalent bonds. Additionally, DBCO-PEG6-NHS ester contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide groups.

DBCO-PEG3-NHS ester is a degradable ADC linker that can be used to synthesize antibody-coupled active molecules.