dbco nhs ester

DBCO-NHS ester is an ADC linker, cleavable 3-unit PEG, which can also be used to synthesize antibody drug conjugates (ADCs).

DBCO-NHS ester 2 is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) and is a Dibenzylcyclooctyne (DBCO) derivative designed for copper-free click chemistry [1].

DBCO-NHS ester 3 (Compound 12) is a cleavable linker utilized in the synthesis of antibody-drug conjugate (ADC). It is a derivative of Dibenzylcyclooctyne (DBCO) resulting from the activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azido group. The DBCO group, known for its strain-promoted high energy, is typically used in copper-free click chemistry reactions. The NHS ester can react with amino acids or other molecules containing amino groups.

DBCO-NHCO-PEG4-NHS ester ester is a MMP-2- and cathepsin B- (CatB) cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NHCO-PEG5-NHS ester is a polyethylene glycol (PEG)-based linker used in the synthesis of PROTACs [1].

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

DBCO-Sulfo-NHS ester sodium is a degradable ADC linker that can be used to synthesize ADC compounds.

DBCO-CONH-S-S-NHS ester is a disulfide-linked ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-NH-PEG7-C2-NHS ester is a polyethylene glycol (PEG) derived linker with a terminal DBCO moiety, functioning as an N-hydroxysuccinimide (NHS) ester, and suitable for the efficient synthesis of proteolysis-targeting chimeras (PROTACs)[1].

DBCO-NHCO-C4-NHS ester, an alkyl chain-derived PROTAC linker, is used for PROTAC synthesis[1].

DBCO-NHCO-PEG13-NHS ester is a pegylated PROteolysis-TArgeting Chimera (PROTAC) linker, serving as a valuable tool for PROTAC synthesis [1].

DBCO-NHCO-PEG2-NHS ester, a PEG-based PROTAC linker, enables the synthesis of PROTACs[1].

DBCO-NHCO-S-S-NHS ester is a cleavable linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-PEG1-NHS ester is a PEG-based linker for PROTACs, facilitating the conjugation of two essential ligands necessary for PROTAC molecule formation. This linker enables selective protein degradation by utilizing the ubiquitin-proteasome system within cells.

DBCO-PEG12-NHS ester is a PEG-based PROTAC linker for synthesising PROTAC molecules, whose DBCO group undergoes click chemistry with azide-containing molecules.

DBCO-PEG8-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

DBCO-PEG13-NHS ester is a PEG-type PROTAC linker useful in the synthesis of PROTAC molecules. This compound acts as a click chemistry reagent and contains a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

PC DBCO-PEG4-NHS ester, a PEG-based linker for PROTACs, connects two essential ligands to form PROTAC molecules, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

DBCO-PEG2-NHS ester is a click chemistry reagent featuring an azide group and an NHS ester, designed for copper-free Click Chemistry. It specifically and efficiently reacts with primary amines (e.g., lysine residue side chains or aminosilane-coated surfaces) under neutral or slightly basic conditions to form stable covalent bonds. The inclusion of a hydrophilic PEG spacer enhances water solubility and provides a flexible linkage, reducing steric hindrance during ligation. This compound, intended for research use only [1], is ideal for applications requiring precise and efficient bioconjugation.

DBCO-PEG24-NHS ester is a click chemistry reagent featuring an NHS ester functionality, allowing for specific and efficient covalent bonding with primary amines (such as lysine residue side chains or aminosilane-coated surfaces) under neutral or slightly basic conditions. The hydrophilic polyethylene glycol spacer not only enhances solubility in water but also provides a long and flexible linkage that minimizes steric hindrance during the coupling process. Commonly used in copper-free click chemistry, DBCO-PEG24-NHS ester is available for research purposes only.

DBCO-N-bis(PEG4-NHS ester) is a PEG linker equipped with one DBCO moiety and two PEG4-NHS esters. This compound serves as a versatile tool in click chemistry, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing molecules. It is commonly utilized for protein modification or labeling, making it a valuable reagent in biochemical applications.

DBCO-PEG16-NHS ester is a PEG derivative composed of DBCO, PEG units, and an NHS ester. The NHS ester can react with amino acids or other amine-containing molecules. The DBCO group in DBCO-PEG16-NHS ester can engage in a strain-promoted alkyne-azide cycloaddition reaction (SPAAC) with azide-containing molecules.

Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent featuring an azide group. It serves as an analog of DBCO-acid, incorporating a PEG linker and a DBCO group. The DBCO group is often utilized in copper-free click reactions due to its high-energy strain. The hydrophilic polyethylene glycol chain and sulfo group enhance its water solubility. The terminal carboxylic acid can react with primary amine groups to form stable amide bonds in the presence of activators such as EDC or HATU. This is a reagent-grade compound intended solely for research purposes.