d-105

M 15 liquid crystals are a member of the oxycyanobiphenyl family, which exhibits a liquid crystalline phase in the temperature range of 47-67.5℃.

Panadiplon (FG 10571) is a selective gamma-aminobutyric acid receptor agonist and partial agonist of 5GABAA, a benzodiazepine receptor, used in the treatment of anxiety disorders.Panadiplon exhibits selectivity for 5GABAA receptors versus 1GABAA receptors.

1-(3-METHYLBENZYL)PIPERAZINE, with CAS No. 5321-48-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-(3-METHYLBENZYL)PIPERAZINE provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride ,with CAS No. 105655-01-4, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

AD1058 is a potent and selective ATR inhibitor (IC50 = 1.6 nM) that crosses the blood-brain barrier with significant in vivo anticancer activity. It is commonly used in the study of brain metastasis and CNS metastasis by inhibiting cell proliferation, disrupting the cell cycle and inducing apoptosis.

BD1052 is a σ-receptor agonist known to intensify the behavioral toxicity of cocaine.

PPD 10558, a HMG-CoA reductase inhibitor, is used potentially for treatment of primary hypercholesterolemia.

Carotuximab (DE-122) is a novel endocholine antibody with strong antiangiogenic and anti-inflammatory activity. Carotuximab blocks endothelial glycoprotein (CD105) and its downstream Smad signaling pathway. Carotuximab has immunomodulatory and antitumor effects to prevent human endothelial dysfunction induced by hypercholesterolemia and hyperglycemia.

Bemfivastatin hemicalcium (PPD 10558), an orally active HMG-CoA reductase inhibitor, serves as a lipid-lowering agent. It amplifies liver extract activity and exhibits no-observed adverse effect levels (NOAEL) at dosages of ≥320 mg/kg/d for rat developmental toxicity, ≥12.5 mg/kg/d for rabbit maternal toxicity, and ≥25 mg/kg/d for rabbit developmental toxicity. This compound is utilized in research concerning hypercholesterolemic myalgia in patients intolerant to statins.

Carotuximab-MMAE, an ADC, comprises a CD105-targeted antibody linked to Monomethyl auristatin E (MMAE), displaying notable antitumor properties.

(R)-(-)-Ibuprofen-d3 is the deuterated form of (R)-(-)-Ibuprofen. This isomer of Ibuprofen, while inactive against COX, is capable of inhibiting NF-κB activation. It possesses anti-inflammatory properties and can be used in studies focused on pain relief.

Pentanoic acid-d3 is the deuterium-labeled version of Pentanoic acid. Pentanoic acid is a short-chain fatty acid and a bacterial metabolite that has been associated with allergic skin diseases. It also has the ability to activate the ROCK signaling pathway.

L-Alanine-13C2,15N is an isotopically labeled form of L-Alanine, marked with 13C and 15N. L-Alanine is a non-essential amino acid involved in carbohydrate and acid metabolism, boosts the immune system, and provides energy to muscle tissues, the brain, and the central nervous system.

Acetylcysteine-d3 is the deuterated form of Acetylcysteine. Acetylcysteine (N-Acetylcysteine), a mucolytic agent, is utilized to decrease mucus viscosity. It functions as an ROS inhibitor and serves as a precursor to cysteine. By neutralizing the toxic lipids produced via arachidonic acid-dependent 5-lipoxygenase activity, it helps prevent ferroptosis induced by heme. Furthermore, Acetylcysteine can trigger apoptosis and exhibits antiviral activity against influenza viruses. It represents the most stable form of cysteine for drug delivery, suitable for disulfidptosis research.

Xylose-5-13C is a 13C-labeled form of xylose. D-(+)-(Xylose) is a natural compound that, when catalyzed by xylose isomerase, forms xylulose, a crucial step in the anaerobic ethanol fermentation of xylose.

Pyruvic acid-13C,d4 is the deuterated form of 13C-labeled pyruvic acid. It acts as an intermediate metabolite in the metabolic pathways of carbohydrates, proteins, and fats.

Taurodeoxycholate-d6 sodium salt is an anionic detergent related to bile salts. It is formed in the liver by conjugating deoxycholic acid with taurine. This compound is utilized for the separation of membrane proteins, including those in the mitochondrial inner membrane. Taurodeoxycholate-d6 (TDCA) exhibits anti-inflammatory and neuroprotective properties.

(±) Anabasine-d4 is the deuterium-labeled version of (±) Anabasine-d4.

Myristic acid-d5 is the deuterated form of myristic acid. Myristic acid, a saturated fatty acid containing 14 carbon atoms, is commonly found in various animal and plant fats, notably in butterfat, coconut oil, palm oil, and nutmeg oil.

Doxycycline-d3 hyclate is a tritium-labeled version of Doxycycline hyclate.

Bendamustine D4 is the deuterium-labeled Bendamustine. Bendamustine is a DNA cross-linking compound with alkylating and antimetabolite properties. Bendamustine causes DNA breaks.