antiplasmodial

Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with the IC50 value of 5.80 uM, it also s

Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).

Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.

Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta.

Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).

3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial activity with IC50 values in the rang

(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) possesses antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1.

5,7-Dihydroxycoumarin, a coumarin isolated from the inflorescences of Macaranga triloba, exhibits antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic activities of Macaranga triloba. Fitoterapia. 2012 Jul;83(5):968-72. [2]. Yi-Ping Chin, et al. Synthesis and evaluation of antibacterial activities of 5,7-dihydroxycoumarin derivatives. Arch Pharm (Weinheim). 2011 Jun;344(6):386-93.

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

Jatrorrhizine hydroxide is an alkaloid extracted from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active acetylcholinesterase inhibitor (IC₅₀ = 872 nM) with over 115-fold selectivity over BuChE. Jatrorrhizine hydroxide reduces serotonin and norepinephrine uptake by blocking dopamine uptake-2 transporters.

Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1].

Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels

2',6'-Dihydroxy 4'-methoxydihydrochalcone (Standard) is a reference standard for research and analysis in studies involving 2',6'-Dihydroxy 4'-methoxydihydrochalcone. 2',6'-Dihydroxy 4'-methoxydihydrochalcone is an orally active dihydrochalcone with antiplasmodial and anti-inflammatory activity, reducing IL-1β, TNF, and nitrite production in vitro while modulating macrophage inflammatory protein secretion and preventing L-selectin cleavage in neutrophils. Toxicological evaluation showed no significant acute toxicity, reinforcing its applicability for inflammation-related pharmacology and infectious disease studies.

(-)-Catechin gallate (Standard) is a reference standard for research and analysis in studies involving (-)-Catechin gallate. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) possesses antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 and chloroquine-resistant Plasmodium falciparum K1.

Jatrorrhizine hydrochloride (Standard) is a reference standard for research and analysis in studies involving Jatrorrhizine hydrochloride. Jatrorrhizine hydrochloride is a compound extracted from the roots of Berberis vulgaris with neuroprotective, antimicrobial, antiplasmodial, and antioxidant activities.Jatrorrhizine hydrochloride is an orally active and selective inhibitor of acetylcholinesterase (AChE), which inhibits norepinephrine (NE) uptake. It inhibits the uptake of norepinephrine (NE).

Betulinic acid methyl ester is a natural product exhibiting growth-inhibitory effects against mouse B16 2F2 melanoma cells (IC50=4.9 μM).

Kobusin, a bisepoxylignan compound isolated from Pnonobio biondii Pamp, demonstrates CFTR and CaCC chloride channel activation properties while exhibiting inhibitory effects on ANO1/CaCC channels.

Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial