antiplasmodial

CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor.

Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits monoamine oxidase (IC50 4 micromolar for MAO-A and 62 for MAO-B).

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.

Bis-propargyl-PEG3 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs. It is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (ZnDPA) complexes[1] [2].

Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.

Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM.

Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity against cancer cells, KB, BC1, NCI-H

Cassiachromone has antiplasmodial activity

Antimalarial agent 28 (Compound 2i) is an antiplasmodial agent that inhibits P. berghei with IC50 values of 0.561 μM for the liver stage, 0.14 μM for early gametocytes, and 4.34 μM for the ring stages of P. falciparum [1].

Antimalarial agent 33 (compound 5g) exhibits antiplasmodial activity targeting both erythrocytic and hepatic stages of Plasmodium, with an effective concentration (EC50) of 1.1 μM against the K1 strain of P. falciparum. It demonstrates improved microsomal stability with a half-life (T1 2) of 29 minutes and displays no significant cytotoxicity against primary hepatocytes [1].

Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 hippocampal neurons.

Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Heraclenin displays significant levels

Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.

3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial activity with IC50 values in the rang

Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and peroxynitrite scavenging potential. Kobusin can mildly reduce gastrointestinal motility in mice, it activates CFTR and CaCCgie chloride channel activities in mouse colonic epithelia and shows inhibitory effects toward ANO1 CaCC-mediated short-circuit currents in ANO1 CaCC-expressing FRT cells.

Neocryptolepine (Cryptotackieine) exhibits antiplasmodial activity, antibacterial activity against Gram-positive bacteria (MIC < 100 μg mL), and antifungal activity [1] [2].

MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity index (SI>250) [1].

Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixture of uncarinic acid E and 27-O-p-(

Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial

Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1].

Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta.

11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.

Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.

Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytotoxic activity against KB cells. Liriodenine also has antiplasmodial activity.