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Search Results for " antiplasmodial "

10

Compounds

38

Natural Products

Cat No. Product Name Synonyms Targets
T25402 Fagaramide AI330755,AI3 30755,AI3-30755
Fagaramide possesses Antiplasmodial activity.
T14656 Bis-propargyl-PEG3 Others
Bis-propargyl-PEG3 is a PEG-based PROTAC linker utilized for the synthesis of PROTACs. It is also employed in the synthesis of antiplasmodial zinc-dipicolylamine (ZnDPA) complexes[1] [2].
T71289 9-O-Demethyltrigonostemone
9-O-Demethyltrigonostemone is a natural IDO1 inhibitor, cytotoxic and antiplasmodial agent from the Roots of Strophioblachia fimbricalyx.
T116970 TLC3407-3786
MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity ...
T75640 Thalifendine chloride
Thalifendine chloride is a metabolite of Berberine , with antiplasmodial and antiamoebic activities. Thalifendine chloride shows activities against P. falciparum and E. histolytica with IC 50 s of 7.91 μM and 116 μM, res...
T75536 Koshidacin B
Koshidacin B, a cyclic tetrapeptide, exhibits potent antiplasmodial activity, evidenced by its ability to inhibit Plasmodium falciparum strains FCR3 and K1 with IC50 values of 0.89 μM and 0.83 μM, respectively. It has be...
T79460 Antimalarial agent 28 Parasite
Antimalarial agent 28 (Compound 2i) acts as an antiplasmodial agent, exhibiting inhibition of P. berghei with IC50 values of 0.561 μM for the liver stage, 0.14 μM for early gametocytes, and 4.34 μM for the ring stages of...
T60998 Anticancer agent 75
Anticancer agent 75 has good antiplasmodial activity. Anticancer agent 75 is a potent anticancer agent with cytotoxicity and selectivity in cancer cell lines. The cytotoxicity of Anticancer agent 75 to normal human kidne...
T83044 Antimalarial agent 33 Parasite
Antimalarial agent 33 (compound 5g) exhibits antiplasmodial activity targeting both erythrocytic and hepatic stages of Plasmodium, with an effective concentration (EC50) of 1.1 μM against the K1 strain of P. falciparum. ...
T35757 Beauvericin A
Beauvericin A is a cyclodepsipeptide and derivative of beauvericin originally isolated fromB. bassianathat has diverse biological activities.1,2,3It is active againstM. tuberculosis(MIC = 25 μg/ml) andP. falciparum(IC50=...
Cat No. Product Name Synonyms Targets
TN1610 Epimagnolin A Parasite
Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.
TN3466 Atherosperminine cAMP , Calcium Channel , AChR , Parasite
Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t...
TN2239 Strictosamide ATPase , Potassium Channel , Sodium Channel , Parasite , Antifungal
Strictosamide possesses antibacterial and antiviral activities, it also may have important effects on inflammation and inflammatory pain.
T3933 Jatrorrhizine Yatrorizine,neprotin MAO , 5-HT Receptor , Antibacterial , AChE
Jatrorrhizine (neprotin) is a protoberberine alkaloid isolated from Enantia chlorantha (Annonaceae) and other species. It was found to have antimicrobial and antifungal activity. It binds and noncompetitively inhibits mo...
T4912 Jatrorrhizine chloride Yatrorhizine chloride,Neprotine chloride Others , 5-HT Receptor , OCT , Antibacterial , AChE
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...
T8206 Cycleanine Others
Cycleanine has potent antibacterial, antifungal, antiplasmodial, and cytotoxic activities.
T11811 Laetanine Parasite
Laetanine, exhibits antiplasmodial activity, a noraporphine alkaloid from Litsea laeta.
T3832 11-O-Galloylbergenin Antioxidant , Immunology/Inflammation related
11-O-Galloylbergenin is isolated from of Mallotus philippinensis with antioxidant and antiplasmodial activities.
TN1531 Cratoxylone Antifungal
Cratoxylone is a triterpenoid from the bark of Symphytum officinale with antiplasmodial activity and potential antitumor and antioxidant activity.
TL0013 Heraclenin Anti-infection , Immunology/Inflammation related
Heraclenin has anticoagulant, and anti-inflammatory activities, it also has mutagenicity in Chlamydomonas reinhardii. Heraclenin can induce apoptosis in Jurkat leukemia cells, it has a strong clastogenic effect . (+)-Her...
T3682 (-)-Catechin gallate (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate Others , COX
(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...
T2S1635 3-Isomangostin MTH1
3-Isomangostin is a potent human aldose reductase inhibitor with an IC50 of 3.48 uM; it is also an acetylcholinesterase selective inhibitor. 3-Isomangostin has free radical scavenging activity; it shows antiplasmodial ac...
T37345 5,7-Dihydroxycoumarin Antibacterial
5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescences of Macaranga triloba. 5,7-Dihydroxycoumarin has antibacterial activities[1][2]. [1]. Ishak Zakaria, et al. Flavonoids with antiplasmodial and cytotoxic...
TN5327 11(13)-Dehydroivaxillin
11(13)-Dehydroivaxillin possesses a promising antiplasmodial activity, which can be exploited in malaria therapy.
TN2380 Glycerol 1-(26-hydroxyhexacosanoate) Others
Glycerol 1-(26-hydroxyhexacosanoate) has weak activities antiplasmodial
TN2418 Cassiachromone Others
Cassiachromone has antiplasmodial activity
T11681 Isochondrodendrine Isochondrodendrin Others
Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.
TN2413 Diacetylpiptocarphol Others
Diacetylpiptocarphol has antiplasmodial activity
TN5657 Goniotriol
Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity a...
TN2650 16-Oxocleroda-3,13E-dien-15-oic acid Antifection
16-Oxocleroda-3,13E-dien-15-oic acid shows antiplasmodial activity.
TN4387 Khellactone Antifection
Khellactone shows antitumor activity,it can suppress the growth of NCI-H460 tumor cells. (+)-4'-cis-Khellactone and (+)-3'-cis-khellactone have antiplasmodial activities, they show notable inhibitory activity against -se...
TN3456 Artoheterophyllin B Antifection
Artoheterophyllin B has antiplasmodial activity.
TN4218 Homaloside D Antifection
Homaloside D has antiplasmodial activity.
TN3707 Coronarin B Antifection
Coronarin B has cytotoxic activity, it also has modest antiplasmodial activity.
TN1442 Betulinic acid methyl ester Antifection
Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.
TN4443 Lipiferolide Telomerase , Antifection
Lipiferolide is an inhibitor of farnesyl protein transferase(FPTase), it inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, it possesses cytoto...
TN6009 Pseudopalmatine
Pseudopalmatine exhibits antiplasmodial activity. It also shows anti-acetylcholinesterase (AChE) activity, with IC50 values of 1.8uM.
TN3583 Canophyllal Antifection
Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.
TN3124 5-Hydroxysophoranone Antibacterial , Parasite , Antifection
5-Hydroxysophoranone is extracted from Erythrina subumbrans stems and exhibits high antiplasmodial activity against Plasmodium falciparum (IC50 = 2.5 μg/mL).
TN2867 3,4,5-Trimethoxyphenyl-(6-O-galloyl)-O-beta-D-glucopyranoside Antifection
3,4,5-Trimethoxyphenyl-(6'-O-galloyl)-O-beta-D-glucopyranoside shows in vitro antiplasmodial activity.
T11509 Guanfu base H Atisinium chloride Others
Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).
TN1930 Methylenetanshinquinone Antifection
Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
T75568 Z-Antiepilepsirine
Z-Antiepilepsirine is an amide alkaloid that can be found in Piper capense L.f . Z-Antiepilepsirine shows antiplasmodial activity with an IC 50 value of 27 µM for W2 strain of Plasmodium falciparum [1] .
TN1834 Kobusin Others , NOS , NF-κB
Kobusin, a Calmodulin inhibitor, shows mild antiplasmodial,anti-inflammatory, and cytotoxic activities; it may be beneficial for the treatment of neuro-inflammatory diseases through the inhibition of iNOS expression and ...
TN5061 Stephanine Adrenergic Receptor , Antifection
l-Stephanine is a potent and highly selective alpha 1 adrenoceptor blocker, inhibits anococcygeus muscle contraction induced by phenylephrine with pA2 values of 6.76. Stephanine shows significant antiplasmodial activitie...
TN5201 Uncarinic acid E BCL , MEK , Caspase , PI3K , Antifection , p53
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resulting in cytochrome c release from the mitochondria. A mixtu...
T75436 Jatrorrhizine hydroxide
Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities [1] . Jatrorrhizine hydroxide is a potent and orally active inhibitor o...
TN2190 Scoulerine Apoptosis , Beta-Secretase , BACE , Parasite
Scoulerine is an inhibitor of ß-site amyloid precursor protein cleaving enzyme 1(BACE1). Scoulerine a potent antimitotic compound that inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells.

Natural Products

Epimagnolin A
TN1610
Synonym:
Target: Parasite
Atherosperminine
TN3466
Synonym:
Target: cAMP, Calcium Channel, AChR, Parasite
Strictosamide
TN2239
Synonym:
Target: ATPase, Potassium Channel, Sodium Channel, Parasite, Antifungal
Jatrorrhizine
T3933
Synonym: Yatrorizine,neprotin
Target: MAO, 5-HT Receptor, Antibacterial, AChE
Jatrorrhizine chloride
T4912
Synonym: Yatrorhizine chloride,Neprotine chloride
Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE
Cycleanine
T8206
Synonym:
Target: Others
Laetanine
T11811
Synonym:
Target: Parasite
11-O-Galloylbergenin
T3832
Synonym:
Target: Antioxidant, Immunology/Inflammation related
Cratoxylone
TN1531
Synonym:
Target: Antifungal
Heraclenin
TL0013
Synonym:
Target: Anti-infection, Immunology/Inflammation related
(-)-Catechin gallate
T3682
Synonym: (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate
Target: Others, COX
3-Isomangostin
T2S1635
Synonym:
Target: MTH1
5,7-Dihydroxycoumarin
T37345
Synonym:
Target: Antibacterial
11(13)-Dehydroivaxillin
TN5327
Synonym:
Target:
Glycerol 1-(26-hydroxyhexacosanoate)
TN2380
Synonym:
Target: Others
Cassiachromone
TN2418
Synonym:
Target: Others
Isochondrodendrine
T11681
Synonym: Isochondrodendrin
Target: Others
Diacetylpiptocarphol
TN2413
Synonym:
Target: Others
Goniotriol
TN5657
Synonym:
Target:
16-Oxocleroda-3,13E-dien-15-oic acid
TN2650
Synonym:
Target: Antifection
Khellactone
TN4387
Synonym:
Target: Antifection
Artoheterophyllin B
TN3456
Synonym:
Target: Antifection
Homaloside D
TN4218
Synonym:
Target: Antifection
Coronarin B
TN3707
Synonym:
Target: Antifection
Betulinic acid methyl ester
TN1442
Synonym:
Target: Antifection
Lipiferolide
TN4443
Synonym:
Target: Telomerase, Antifection
Pseudopalmatine
TN6009
Synonym:
Target:
Canophyllal
TN3583
Synonym:
Target: Antifection
5-Hydroxysophoranone
TN3124
Synonym:
Target: Antibacterial, Parasite, Antifection
3,4,5-Trimethoxyphenyl-(6-O-galloyl)-O-beta-D-glucopyranoside
TN2867
Synonym:
Target: Antifection
Guanfu base H
T11509
Synonym: Atisinium chloride
Target: Others
Methylenetanshinquinone
TN1930
Synonym:
Target: Antifection
Z-Antiepilepsirine
T75568
Synonym:
Target:
Kobusin
TN1834
Synonym:
Target: Others, NOS, NF-κB
Stephanine
TN5061
Synonym:
Target: Adrenergic Receptor, Antifection
Uncarinic acid E
TN5201
Synonym:
Target: BCL, MEK, Caspase, PI3K, Antifection, p53
Jatrorrhizine hydroxide
T75436
Synonym:
Target:
Scoulerine
TN2190
Synonym:
Target: Apoptosis, Beta-Secretase, BACE, Parasite
TargetMol