Search Result

Search Results for " adipogenesis "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T9568	SGC-SMARCA-BRDVIII		Epigenetic Reader Domain
	SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM, respectively.		Epigenetic Reader Domain
T9266	Fatostatin		Lipid , Fatty Acid Synthase
	Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.		Lipid , Fatty Acid Synthase
T1057	Azilsartan	TAK-536	RAAS
	Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker. The mechanism of action of azilsartan is as an Angiotensin 2 Type 1 Receptor Antagonist. The physiologic effect of azilsartan is by means of Decreased Blood Pres...		RAAS
T6832	Fatostatin hydrobromide	Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin	NPC1L1 , Fatty Acid Synthase
	Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.		NPC1L1 , Fatty Acid Synthase
T30577	BRD0418	BRD 0418,BRD-0418	Others
	BRD0418 acts as an upregulator of TRIB1 expression by leading to reprogramming of hepatic lipoprotein metabolism from adipogenesis to clearance it.		Others
T7621	6-Thioinosine	6-Mercaptopurine riboside,6TI	Nucleoside Antimetabolite/Analog
	6-Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent.		Nucleoside Antimetabolite/Analog
T77788	Palmitic acid sodium	Sodium palmitate,Palmitic acid sodium
	Palmitic acid sodium (Sodium palmitate) is a type of saturated fatty acid that is formed in fatty acid synthesis.Palmitic acid sodium promotes adipogenesis and cellular lipoatrophy in a variety of cell lines.
T24182	ISX-1	ISX 1	Others
	ISX-1 inhibits adipogenesis and promotes osteoblastogenesis. ISX-1 can be used in studies about osteoporosis and osteopenia.		Others
T6337	RepSox	ALK5 Inhibitor II,SJN 2511,E-616452	ALK , TGF-beta/Smad
	RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM). RepSox induces adipogenesis in MEFs cells.		ALK , TGF-beta/Smad
T13289	EHP-101	VCE-004.8	Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
	EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.		Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
T61548	Anti-inflammatory agent 22
	Anti-inflammatory agent 22 (compound 14a) is a potent orally active compound with anti-inflammatory properties. It effectively inhibits the production of TNF-α induced by LPS, exhibiting an IC50 value of 14.6 μM. Additio...
T36471	Ternatin
	Ternatin is a cyclic heptapeptide first isolated from the mushroom C. versicolor that has been shown to have cytotoxic and anti-adipogenic effects in vitro. It inhibits adipogenesis with an IC50 value of 27 nM and become...
T64171	LXR antagonist 2
	LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge...
T72034	LI-2242		Others
	LI-2242 is a potent inositol hexakisphosphate kinase (IP6K) inhibitor with IC50s of 31 nM, 42 nM, 8.7 nM, and 1944 nM for IP6K1, IP6K2, IP6K3, and IPMK, respectively.LI-2242 ameliorated hepatic steatosis by reducing the ...		Others

Compounds

SGC-SMARCA-BRDVIII

T9568

Synonym:

Target: Epigenetic Reader Domain

Fatostatin

T9266

Synonym:

Target: Lipid, Fatty Acid Synthase

Fatostatin hydrobromide

T6832

Synonym: Fatostatin HBr,Fatostatin A,Fatostatin A HBr,Fatostatin

Target: NPC1L1, Fatty Acid Synthase

BRD0418

T30577

Synonym: BRD 0418,BRD-0418

Target: Others

6-Thioinosine

T7621

Synonym: 6-Mercaptopurine riboside,6TI

Target: Nucleoside Antimetabolite/Analog

Palmitic acid sodium

T77788

Synonym: Sodium palmitate,Palmitic acid sodium

Synonym: ALK5 Inhibitor II,SJN 2511,E-616452

Target: ALK, TGF-beta/Smad

EHP-101

T13289

Synonym: VCE-004.8

Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR

Anti-inflammatory agent 22

Cat No.	Product Name	Synonyms	Targets
TN1836	Kudinoside D		LDL , AMPK , PPAR
	Kudinoside D exerts anti-adipogenic effects through modulation of adipogenic transcription factors via AMPK signaling pathway.		LDL , AMPK , PPAR
T3836	Eudesmin		MAPK , S6 Kinase
	Eudesmin shows antiinflammatory, neuritogenic, anticonvulsant and sedative effects, the mechanism of eudesmin may be related to up-regulation of GABAA and GAD65 expressions, and anti-apoptosis of neuron the in brain.50 m...		MAPK , S6 Kinase
T2S0712	Sinigrin	Allylglucosinolate,2-Propenylglucosinolate	Others
	Sinigrin (2-Propenylglucosinolate), a glucosinolate, is used as a systrate to identify, differentiate and characterize myrosinase(s)/thioglucoside glucohydrolase(s)/thioglucosidase(s). Sinigrin is used as a reference mat...		Others
T5583	Turanose	D-(+)-Turanose	Endogenous Metabolite
	D(+)-Turanose (D-(+)-Turanose) is a naturally occuring compound. It is a reducing disaccharide.		Endogenous Metabolite
TN2121	3,5,7,3′,4′-Pentamethoxyflavone	Quercetin 3,5,7,3,4-pentamethyl ether	Others
	3,5,7,3′,4′-Pentamethoxyflavone (Quercetin 3,5,7,3,4-pentamethyl ether) is a natural product. It can induce adipogenesis on 3T3-L1 preadipocytes by regulating transcription factors at an early stage of differentiation.		Others
T4S1173	Agrimol B		Sirtuin , PPAR
	1. Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.		Sirtuin , PPAR
T13803	N-Oleoyl glycine		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
	N-Oleoyl Glycine, a Lipoamino Acid, Stimulates Adipogenesis Associated With Activation of CB1 Receptor and Akt Signaling Pathway in 3T3-L1 Adipocyte		Cannabinoid Receptor , Akt , Endogenous Metabolite , PPAR
T4S0227	Sinensetin	Pedalitin permethyl ether	TNF , PGE Synthase
	Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.		TNF , PGE Synthase
T3674	Hydroxysafflor yellow A	HSYA,Safflomin A	TGF-beta/Smad
	Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit...		TGF-beta/Smad
T8184	Fucosterol		PARP , Endogenous Metabolite , PPAR
	Fucosterol is isolated from E. stolonifera with anti-diabetic, anti-adipogenic and anti-cancer activities. It regulates adipogenesis via modulation of PPARα and C/EBPα expression.		PARP , Endogenous Metabolite , PPAR
TN5137	Tetramethylkaempferol		transporter , PPAR
	Tetramethylkaempferol is a PPARγ agonist, it can improve insulin sensitivity by increasing the levels of adiponectin, an important adipocytokine associated with insulin sensitivity in adipose tissue. Tetramethylkaempfero...		transporter , PPAR
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
TN3989	Erycibelline		LDL , PPAR
	Erycibelline has antiobesity activity, it may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.		LDL , PPAR
T81291	Retrofractamide A
	Retrofractamide A, an amide constituent extracted from Piper chaba fruit, enhances adipogenesis in 3T3-L1 cells [1].
TN2228	Soyasaponin Aa		PPAR
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factor...		PPAR
TN4390	Kihadanin B		Akt , PPAR , FOXO1
	Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.		Akt , PPAR , FOXO1
T64246	Cinchonine monohydrochloride hydrate
	Cinchonine ((8R,9S)-Cinchonine) monohydrochloride hydrate is a natural and potent antimalarial agent and an inhibitor of human platelet aggregation. apoptosis in human hepatocellular carcinoma cells and inhibits adipogen...
TN5369	Dehydroleucodine	Dehydroleucodin
	Dehydroleucodine has antidiarrheal, anti-inflammatory, anti-microbial, embryotoxicity, gastric cytoprotective, anti-cancer activities. Dehydroleucodine has an important inhibitory effect in cellular pathways regulating a...
TN4213	Hirsutenone		ERK , EGFR , IL Receptor , NF-κB , Akt , PI3K , Antifection , mTOR , p53 , Autophagy
	Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filaria...
T79949	Foenumoside B		PPAR
	Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotes lipolysis, shifting lipid metabolism. This compound is utilized...		PPAR
TN3366	Ailanthoidol		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR
	Ailanthoidol has anti-inflammatory activity, it inhibits inflammatory reactions by macrophages and protects mice from endotoxin shock. It also possesses potential as a chemopreventive agent against tumor promotion. Ailan...		IL Receptor , NOS , COX , Prostaglandin Receptor , PPAR

Natural Products

Kudinoside D

TN1836

Synonym:

Target: LDL, AMPK, PPAR

Eudesmin

T3836

Synonym:

Target: MAPK, S6 Kinase

Sinigrin

T2S0712

Synonym: Allylglucosinolate,2-Propenylglucosinolate

Target: Others

Turanose

T5583

Synonym: D-(+)-Turanose

Target: Endogenous Metabolite

3,5,7,3′,4′-Pentamethoxyflavone

TN2121

Synonym: Quercetin 3,5,7,3,4-pentamethyl ether

Target: Sirtuin, PPAR

N-Oleoyl glycine

T13803

Synonym:

Target: Cannabinoid Receptor, Akt, Endogenous Metabolite, PPAR

Sinensetin

T4S0227

Synonym: Pedalitin permethyl ether

Target: TNF, PGE Synthase

Hydroxysafflor yellow A

T3674

Synonym: HSYA,Safflomin A

Target: TGF-beta/Smad

Fucosterol

T8184

Synonym:

Target: PARP, Endogenous Metabolite, PPAR

Tetramethylkaempferol

TN5137

Synonym:

Target: transporter, PPAR

Poncirin

T3S2312

Synonym: Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

Prunetin

T4S0878

Synonym: Prunusetin

Target: ERK, Dehydrogenase, NF-κB

Target: Akt, PPAR, FOXO1

Cinchonine monohydrochloride hydrate

Synonym: Dehydroleucodin

Target: ERK, EGFR, IL Receptor, NF-κB, Akt, PI3K, Antifection, mTOR, p53, Autophagy

Target: IL Receptor, NOS, COX, Prostaglandin Receptor, PPAR

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00080	IL-11 Protein, Human, Recombinant（P. pastoris）	Human	P. pastoris
	Interleukin 11 (IL-11) is a member of a family of human growth factors that includes human growth hormone, granulocyte colony-stimulating factor, and other growth factors. IL-11 is a thrombopoietic growth factor that dir...
TMPK-00089	IL-11 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPK-00088	IL-11 Protein, Human, Recombinant (His)	Human	HEK293
	Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which tri...
TMPY-05842	IL-11 Protein, Cynomolgus, Recombinant	Cynomolgus	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-04178	IL-11 Protein, Mouse, Recombinant	Mouse	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPY-03488	IL-11 Protein, Human, Recombinant	Human	E. coli
	IL11 is a multifunctional cytokine first isolated in 199 from bone marrow-derived stromal cells. It is a key regulator of multiple events in hematopoiesis, most notably the stimulation of megakaryocyte maturation. IL11 i...
TMPH-01016	GDF-10 Protein, Human, Recombinant (His)	Human	E. coli
	Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
TMPH-03757	TPP2 Protein, Human, Recombinant (E. coli, His & Myc)	Human	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02250	TPP2 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-01082	CMKLR1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways in...
TMPH-03762	TPP2 Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPH-02953	TPP2 Protein, Mouse, Recombinant (His & Myc)	Mouse	Baculovirus
	Component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. May be able to complement the 26S proteasome function to some extent under conditions in which the latter ...
TMPY-02135	S100A16 Protein, Human, Recombinant	Human	E. coli
	S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting wit...
TMPY-00899	GRO gama/CXCL3 Protein, Human, Recombinant (His)	Human	E. coli
	CXCL3 is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia. CXCL3 autocrine/paracrine pathways are involved in the development...
TMPY-03227	CISD1 Protein, Human, Recombinant (His)	Human	E. coli
	Mitochondrial dysfunction is thought to play a significant role in neurodegeneration observed in Parkinson's disease (PD), the loss of mitoNEET (CISD1), an iron-sulfur containing protein that regulates mitochondrial bioe...
TMPY-04703	GRO gama/CXCL3 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	CXCL3 is involved in migration, invasion, proliferation and tubule formation of trophoblasts and may play a key role in the pathogenesis of preeclampsia. CXCL3 autocrine/paracrine pathways are involved in the development...
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autopho...
TMPY-01427	AACS Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Acetoacetyl-CoA Synthetase (AACS) is a novel cytosolic ketone body (acetoacetate)-specific ligase. The AACS in adipose tissue plays an important role in utilizing ketone body for the fatty acid-synthesis during adipose t...
TMPH-01791	RORA Protein, Human, Recombinant (His)	Human	E. coli
	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of embryonic development, cellular d...
TMPH-02640	ZC3H12A Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...
TMPH-02690	PLA2G10 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatid...
TMPH-01792	RORC Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunit...