acetaminophen

Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7/25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.

Paracetamol Mercapturate is a metabolite of Acetaminophen. It can also be used in the biological study of urinary antihypertensive drugs.

Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic microsomal metabolite of acetaminophen, suitable for metabolic studies. It functions as an antioxidant, exhibiting radical scavenging activity via its phenolic hydroxyl group to mitigate oxidative damage.

Acetaminophen Glucuronide sodium salt (APAP-glu) is a compound with antipyretic and analgesic activity and is an acetaminophen metabolite with potential nephrotoxicity.

Paracetamol-cysteine TFA (APAP-Cys TFA) is a metabolite of Paracetamol, a biomarker of paracetamol metabolism.

Acetaminophen (Standard) is a reference standard for acetaminophen used in QC and analytical studies. Acetaminophen inhibits COX-1 and COX-2 (IC₅₀ = 113.7 / 25.8 μM), and has antipyretic and analgesic activity with weak anti-inflammatory effects.

3-Methylacetaminophen is a bioactive chemical.

Metacetamol (3-Acetamidophenol) is a derivative of acetaminophen, a non-toxic regional isomer of acetaminophen. It is an over-the-counter analgesic and antipyretic and is also used as an organic synthesis intermediate.

2-Hydroxybutyric acid (α-Hydroxybutyric acid) is a product of protein metabolism and serves as a biomarker for type 2 diabetes and pre-eclampsia.

Cholesteryl Hemisuccinate (Cholesterol hydrogen succinate) is a highly soluble cholesterol analogue often used in polar solutions for its hepatoprotective, anticancer and tumour growth inhibiting properties. Cholesteryl Hemisuccinate inhibits the hepatotoxicity of acetaminophen and prevents AAP-induced apoptosis and necrosis in hepatocytes. Cholesteryl Hemisuccinate inhibits DNA polymerase and DNA topoisomerase, thereby inhibiting DNA replication and repair as well as cell division.

4-Acetamidophenyl acetate, an impurity of Acetaminophen, which is a selective COX-2 inhibitor (IC50: 25.8 μM) and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.

4-Hydroxyacetophenone oxime is an impurity of Acetaminophen (Paracetamol), a potent COX-2 and hepatic NAT2 inhibitor used as an antipyretic and analgesic drug.

Ferroptosis-IN-16 (Compound 13l) acts as a specific inhibitor of ferroptosis, demonstrating EC50 values of 0.7 nM in ES-2 cells and 0.9 nM in LX-2 cells. It effectively alleviates acute liver injury induced by Acetaminophen in mouse models and shows excellent metabolic stability in mouse liver microsomes.

ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In a mouse liver injury model induced by Acetaminophen, ASK1-IN-8 significantly reduces plasma alanine aminotransferase (ALT) levels, offering liver protection. This compound is useful for research in liver disease-related fields.

DW34 is an orally bioactive pan-BRD4-D1-biased inhibitor that also exhibits BRD4-D2 activity. It demonstrates a low nanomolar inhibitory effect comparable to I-BET151 (EC50 value of 0.16 μM), with an EC50 value of 0.14 μM. DW34 significantly alleviates lipopolysaccharide (LPS)-induced liver inflammation and acetaminophen (APAP)-induced toxicity by reducing chemokine expression and cell necrosis.

Paracetamol mercapturate is a deuterated metabolite of acetaminophen.

L-Cysteine-glutathione disulfide is a potential biomarker for curing tuberculosis, present in mammalian cells with hepatoprotective effects, useful in acetaminophen-induced liver toxicity research.

Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Propacetamol Hydrochloride (Propacetamol HCL) is a prodrug of paracetamol (acetaminophen) with improved water solubility. Propacetamol Hydrochloride is an analgesic drug delivered by IV when the oral application of NSAID is not appropriate or contradicted.

FSG67 is a glycerol 3-phosphate acyltransferase (GPAT) and glycerol-3-phosphate acyltransferase, mitochondrial (GPAM) inhibitor that attenuates hepatic regeneration following acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling.

DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substrate, in mouse liver and effectively protects mice from acetaminophen-induced liver injury.

Keap1-Nrf2-IN-1 TFA (compound35) is a Keap1-Nrf2 protein-protein interaction inhibitor (IC50: 43 nM) that activates Nrf2-regulated cytoprotective responses and antagonizes acetaminophen-induced liver injury in both cellular and in vivo models.

PUMAi is an inhibitor of p53 up-regulated modulator of apoptosis (PUMA), a BH3-only Bcl-2 family member, mitigating acetaminophen (APAP)-induced hepatocyte necrosis and liver injury.

CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.