acetaminophen

Acetaminophen (APAP) is a COX inhibitor that inhibits COX-1 and COX-2 (IC50=113.7 25.8 μM). Acetaminophen has antipyretic and analgesic activity as well as weak anti-inflammatory activity.

2-Hydroxybutyric acid (α-Hydroxybutyric acid) is a product of protein metabolism and serves as a biomarker for type 2 diabetes and pre-eclampsia.

Saikosaponin D is a novel SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity.

Larsucosterol trimethylamine (DUR-928 trimethylamine) is a potent liver X receptor (LXR) antagonist that modulates endogenous epigenetics, reduces lipid accumulation in hepatocytes, attenuates lipopolysaccharide (LPS) and TNFα-induced inflammatory responses in macrophages, and alleviates LPS- and acetaminophen (ATMP)-induced multi-organ damage.

Compound 6, known as Heilaohuguosu F, is a tetrahydrofuranolignan demonstrating weak hepatoprotective properties. It exhibits a mild protective effect against acetaminophen (APAP)-induced hepatotoxicity in HepG2 cells.

Fulvotomentoside B, a saponin derived from Lactobacillus flavus, displays hepatoprotective properties. It notably decreases serum glutamate pyruvate transaminase (SGPT) and triacylglycerol (GT) concentrations in mice subjected to hepatic injury induced by CCl₄, d-galactosamine (d-gal), and acetaminophen, while also significantly mitigating liver tissue damage [1].

Homopterocarpin and Pterocarpus extract offer gastroprotection against indomethacin- induced ulcer by antioxidative mechanism and the modulation of gastric homeostasis, homopterocarpin may be responsible for, or contribute to the antiulcerogenic property

N-Acetyldemecolcine (N-Methylcolchicine) is a methylated form of Colchicine.