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Search Result

Search Results for " parp1 "

Targets

PARP

102

Compounds

1

Natural Products

11

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9610 PARP1-IN-5 dihydrochloride  PARP
PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.
T9891 PARP1-IN-8  N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide PARP
PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).
T39139 PARP1-IN-6 PARP1-IN-6
PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM for PARP-1.
T72437 PARP1/2/TNKS1/2-IN-1 Apoptosis , PARP , Wnt/beta-catenin
PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis.
T13845 PROTAC PARP1 degrader Others
PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).
T81543 PARP1-IN-17 PARP
PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis. It exhibits robust anti-proliferative activity [1].
T79405 PARP1-IN-15 PARP
PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ...
T60637 PARP1-IN-11
PARP1-IN-11 (compound 49) is a potent inhibitor of PARP1 with IC50 value of 0.082 μM which shows complete inhibition of PARP1 and substantially inhibits PARP3, TNKS1 and TNKS2 [1].
T73023 PARP1-IN-12
PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces...
T62955 PARP1-IN-5
PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.
T81544 PARP1-IN-16 PARP
PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM. It possesses the capability to halt the cell cycle at the S phase and stimulate apoptosis in HCT-116 cells [1].
T79593 PARP1-IN-14 PARP
PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with ...
T61879 PARP1-IN-7
PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).
T61325 PARP1-IN-9
PARP1-IN-9 (Compound 5c) is a potent PARP1 inhibitor, displaying an IC 50 of 30.51 nM. With its ability to induce cell apoptosis and exhibit anticancer activity, PARP1-IN-9 surpasses Olaparib in terms of efficacy [1].
T61694 PARP1-IN-10
PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while a...
T63471 PARP1/BRD4-IN-1
PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the ma...
T62540 PARP1/BRD4-IN-2
PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-...
T8806 Fluzoparib HS10160,SHR3162 PARP
Fluzoparib (SHR3162) is a novel, potent, and orally available inhibitor of PARP, potentially for the treatment of solid tumours.
T7539 O6-Benzylguanine Apoptosis , DNA Alkylation , DNA/RNA Synthesis
O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
T12412L PDK4-IN-1 hydrochloride Apoptosis , PDK
PDK4-IN-1 hydrochloride is an anthraquinone derivative and a potent and orally active inhibitor of pyruvate dehydrogenase kinase 4 (PDK4)(IC50 value of 84 nM)
T3015 Olaparib AZD2281,KU0059436 Mitophagy , PARP , Autophagy
Olaparib (KU0059436) is a small molecule inhibitor of PARP1/PARP2 (IC50=5/1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and m...
T72553 ARTD10/PARP10-IN-1 PARP
ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activit...
T67932 PARP10-IN-3 PARP
PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 and human PARP15 with IC50 values of 1.7 μM.
T73007 PARP10-IN-2 PARP
PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and PARP15, with IC50 values of 27 μM and 11 μM, respectively.
T72554 ARTD10/PARP10-IN-2
ARTD10/PARP10-IN-2 is a potent, non-selective inhibitor of mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1, exhibiting IC50 values of 2.0 μM and 9.7 μM, respectively.
T12366 PARP14 inhibitor H10 PARP
PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM
T60567 PARP10/15-IN-2
PARP10/15-IN-2 (Compound 8h) is a dual inhibitor of PARP10 and PARP15 with IC 50 values of 0.15 μM and 0.37 μM, respectively. PARP10/15-IN-2 can enter cells and rescue cells from apoptosis [1].
T60309 PARP10/15-IN-3
PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC 50 values of 0.14 μM and 0.40 μM against PARP10 and PARP15, respectively. PARP10/15-IN-3 can enter cells and rescue cells from apoptosis [...
T60495 PARP10/15-IN-1
PARP10/15-IN-1 (compound 8l) is a dual PARP10 and PARP15 inhibitor with IC50s of 160 nM and 370 nM, respectively. It can be used in cancer research[1].
T72397 PARP11 inhibitor ITK7 ITK7
PARP11 Inhibitor ITK7 (ITK7) is a potent, selective inhibitor of PARP11, demonstrating significant efficacy with an IC50 value of 14 nM. It is primarily utilized in research focused on cellular localization.
T7896 BYK204165 RT-017290 PARP
BYK204165 (RT-017290) is a potent PARP inhibitor (PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay)
T7042 1,5-Isoquinolinediol PARP
1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...
T6892 Niraparib tosylate MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate Apoptosis , PARP
Niraparib tosylate (MK-4827 (tosylate))(with IC50 of 3.8 nM/2.1 nM) is a selective PARP1/PARP2 inhibitor.
T12064 Niraparib (R-enantiomer) MK 4827 (R-enantiomer),Niraparib R-enantiomer PARP
Niraparib R-enantiomer (MK 4827 R-enantiomer) is an inhibitor of PARP1(IC50 of 2.4 nM).
T6366 A-966492 PARP
A-96649 is a new-type and effective inhibitor. The Ki of A-966492 for PARP1 and PARP2 is 1 nM and 1.5 nM, respectively.
T2105 Veliparib dihydrochloride ABT-888 dihydrochloride PARP , Autophagy
Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively. It is inactive to SIRT2.
T4471 E7449 Stenoparib,UNII-9X5A2QIA7C Others , PARP
E7449 (UNII-9X5A2QIA7C) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
T22988 MK-4827 Racemate Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide PARP
MK-4827 Racemate (Niraparib Racemate) is a selective PARP1 and PARP2 inhibitor with IC50s of 3.8 nM and 2.1 nM, respectively, over 330-fold selectivity for PARP3, V-PARP and Tank1.
T62281 PARP-1-IN-2 PARP
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cel...
T9430 Venadaparib NOV140101,IDX-1197 PARP
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the...
T6253 Talazoparib LT-673,BMN-673 PARP
Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).
T16807 Rucaparib monocamsylate Rucaparib Camsylate PARP
Rucaparib monocamsylate (Rucaparib Camsylate) is a PARP inhibitor (PARP1,Ki of 1.4 nM). Rucaparib Camsylate also displays binding affinity to eight other PARP domains.
T6339 AG14361 AG 14361,AG-14361 PARP
AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
T3231 Niraparib MK-4827 Apoptosis , Others , PARP
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis.
T2591 Veliparib ABT-888,NSC 737664 PARP , Autophagy
Veliparib (ABT-888) (ABT-888) is an orally bioavailable inhibitor of PARP (Kis: 5.2/2.9 nM for PARP1/2). It enhances apoptosis and autophagy.
T63228 Simmiparib SMOCL-9112 Apoptosis , PARP
Simmiparib (SMOCL-9112) is a novel and potent PARP1 and PARP2 inhibitor, a derivative of Olaparib.Simmiparib induces DNA double-strand breaks (DSBs) and cell cycle arrest in homologous recombination repair (HR)-deficient...
T4463 Rucaparib AG-14447,PF-01367338,AG014699 PARP
Rucaparib (PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1 in a cell-free assay, and also shows binding affinity to eight other PARP.
T50044 5-AIQ PARP
5-aminoisoquinolin-1(2H)-one is the inhibitor of calf thymus PARP1.
T9593 Senaparib IMP4297 PARP
Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with strong antitumor activity.
T50098 TIQ-A PARP
TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in m...

Compounds

PARP1-IN-5 dihydrochloride 
T9610
Synonym:
Target: PARP
PARP1-IN-8 
T9891
Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
Target: PARP
PARP1-IN-6
T39139
Synonym: PARP1-IN-6
Target:
PARP1/2/TNKS1/2-IN-1
T72437
Synonym:
Target: Apoptosis, PARP, Wnt/beta-catenin
PROTAC PARP1 degrader
T13845
Synonym:
Target: Others
PARP1-IN-17
T81543
Synonym:
Target: PARP
PARP1-IN-15
T79405
Synonym:
Target: PARP
PARP1-IN-11
T60637
Synonym:
Target:
PARP1-IN-12
T73023
Synonym:
Target:
PARP1-IN-5
T62955
Synonym:
Target:
PARP1-IN-16
T81544
Synonym:
Target: PARP
PARP1-IN-14
T79593
Synonym:
Target: PARP
PARP1-IN-7
T61879
Synonym:
Target:
PARP1-IN-9
T61325
Synonym:
Target:
PARP1-IN-10
T61694
Synonym:
Target:
PARP1/BRD4-IN-1
T63471
Synonym:
Target:
PARP1/BRD4-IN-2
T62540
Synonym:
Target:
Fluzoparib
T8806
Synonym: HS10160,SHR3162
Target: PARP
O6-Benzylguanine
T7539
Synonym:
Target: Apoptosis, DNA Alkylation, DNA/RNA Synthesis
PDK4-IN-1 hydrochloride
T12412L
Synonym:
Target: Apoptosis, PDK
Olaparib
T3015
Synonym: AZD2281,KU0059436
Target: Mitophagy, PARP, Autophagy
ARTD10/PARP10-IN-1
T72553
Synonym:
Target: PARP
PARP10-IN-3
T67932
Synonym:
Target: PARP
PARP10-IN-2
T73007
Synonym:
Target: PARP
ARTD10/PARP10-IN-2
T72554
Synonym:
Target:
PARP14 inhibitor H10
T12366
Synonym:
Target: PARP
PARP10/15-IN-2
T60567
Synonym:
Target:
PARP10/15-IN-3
T60309
Synonym:
Target:
PARP10/15-IN-1
T60495
Synonym:
Target:
PARP11 inhibitor ITK7
T72397
Synonym: ITK7
Target:
BYK204165
T7896
Synonym: RT-017290
Target: PARP
1,5-Isoquinolinediol
T7042
Synonym:
Target: PARP
Niraparib tosylate
T6892
Synonym: MK-4827 (tosylate),MK 4827 tosylate,Niraparib (MK-4827) tosylate
Target: Apoptosis, PARP
Niraparib (R-enantiomer)
T12064
Synonym: MK 4827 (R-enantiomer),Niraparib R-enantiomer
Target: PARP
A-966492
T6366
Synonym:
Target: PARP
Veliparib dihydrochloride
T2105
Synonym: ABT-888 dihydrochloride
Target: PARP, Autophagy
E7449
T4471
Synonym: Stenoparib,UNII-9X5A2QIA7C
Target: Others, PARP
MK-4827 Racemate
T22988
Synonym: Niraparib Racemate,2-(4-piperidin-3-ylphenyl)indazole-7-carboxamide
Target: PARP
PARP-1-IN-2
T62281
Synonym:
Target: PARP
Venadaparib
T9430
Synonym: NOV140101,IDX-1197
Target: PARP
Talazoparib
T6253
Synonym: LT-673,BMN-673
Target: PARP
Rucaparib monocamsylate
T16807
Synonym: Rucaparib Camsylate
Target: PARP
AG14361
T6339
Synonym: AG 14361,AG-14361
Target: PARP
Niraparib
T3231
Synonym: MK-4827
Target: Apoptosis, Others, PARP
Veliparib
T2591
Synonym: ABT-888,NSC 737664
Target: PARP, Autophagy
Simmiparib
T63228
Synonym: SMOCL-9112
Target: Apoptosis, PARP
Rucaparib
T4463
Synonym: AG-14447,PF-01367338,AG014699
Target: PARP
5-AIQ
T50044
Synonym:
Target: PARP
Senaparib
T9593
Synonym: IMP4297
Target: PARP
TIQ-A
T50098
Synonym:
Target: PARP
1 2 3
Cat No. Product Name Synonyms Targets
T40834 5-Hydroxymethyl-2'-deoxycytidine 5hmdC PARP
5-Hydroxymethyl-2'-deoxycytidine is an oxidized derivative of 5-methyl-2'-deoxycytidine (5-mdC) in DNA, causing DNA damage reactions, chromosomal aberrations, replication fork damage, and loss of cell viability.5-Hydroxy...

Natural Products

5-Hydroxymethyl-2'-deoxycytidine
T40834
Synonym: 5hmdC
Target: PARP

Recombinant Proteins

Species：
Human (9)
Chinese hamster (1)
Mouse (1)
Expression System：
E. coli (7)
Baculovirus-Insect Cells (3)
HEK293 (1)
Tag：
N-terminal 6xHis-tagged (5)
His (2)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (2)
His,GST (1)
Tag-Free (1)
Cat No. Product Name Species Expression System
TMPY-01188 PARP Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPH-01879 PARP11 Protein, Human, Recombinant (His) Human E. coli
Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis.
TMPH-01942 PARP14 Protein, Human, Recombinant (His & Myc) Human HEK293
PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01941 PARP12 Protein, Human, Recombinant (His & Myc) Human E. coli
PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPH-01882 PARP9 Protein, Human, Recombinant (His) Human E. coli
ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses. Within the complex, enhances DTX3L E3 ligase ...
TMPH-03742 EEF1A1 Protein, Cricetulus griseus, Recombinant (His) Chinese hamster E. coli
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IF...
TMPH-01284 EEF1A1 Protein, Human, Recombinant Human E. coli
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IF...
TMPH-01283 EEF1A1 Protein, Human, Recombinant (His) Human E. coli
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IF...
TMPY-02421 PARP3 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular resp...
TMPY-02465 PARP Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Poly (ADP-ribose) polymerase 1(PRAP1), also known as NAD(+) ADP-ribosyltransferase 1(ADPRT), is a chromatin-associated enzyme that modifies various nuclear proteins by poly(ADP-ribosyl)ation. The ADP-D-ribosyl group of N...
TMPH-01057 Caspase-8 Protein, Human, Recombinant (His) Human E. coli
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood...
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