fgfr1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T11279	FGFR1/DDR2 inhibitor 1		Discoidin Domain Receptor (DDR) , FGFR , Others
	FGFR1/DDR2 inhibitor 1 is an inhibitor of discoindin domain receptor 2 (DDR2) and fibroblast growth factor receptor 1 (FGFR1), with IC50 values of 31.1 nM, 108.4 nM and 3.2 nM for FGFR1, KG-1, and DDR2, respectively.		Discoidin Domain Receptor (DDR) , FGFR , Others
T39992	FGFR1 inhibitor-2	FGFR1 inhibitor-2
	FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
T78831	FGFR1 inhibitor-8		FGFR
	FGFR1 inhibitor-8 (Compound 9), an FGFR1 inhibitor with an IC50 of 0.5 nM, binds to the ATP-binding pocket of FGFR1 and exhibits anticancer activity [1].		FGFR
T79686	FGFR1 inhibitor-10		FGFR
	FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation. This compound demonstrates anti-angiogenic and anti-invasion properties, as well as a significant anti-tumor effect [1]...		FGFR
T78830	FGFR1 inhibitor 7		FGFR
	FGFR1 Inhibitor 7 (compound 5), a potent FGFR1 tyrosine kinase inhibitor, exhibits an IC50 of 0.33 nM against its target and demonstrates broad-spectrum cytotoxicity against human cancer cell lines. Additionally, it inhi...		FGFR
T78832	FGFR1 inhibitor-9		FGFR
	FGFR1 inhibitor-9 (Compound 7) is an FGFR1 inhibitor with potent binding affinity, exhibiting an IC50 of 0.85 nM. It targets the ATP-binding pocket of FGFR1 and demonstrates anticancer activity [1].		FGFR
T63816	FGFR1 inhibitor-6
	FGFR1 inhibitor-6 is a potent inhibitor of FGFR1 (IC50: 16.31 nM) with cytotoxic activity. fGFR1 inhibitor-6 is capable of blocking the cell cycle in pro-G1 and G2/M phases and inducing apoptosis.
T78845	FGFR1/VEGFR2-IN-1		VEGFR
	FGFR1/VEGFR2-IN-1 (compound 2b) is an inhibitor of both FGFR1 and VEGFR2, applicable in cancer research [1].		VEGFR
T9030	SU4984		FGFR , IGF-1R , PDGFR
	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).		FGFR , IGF-1R , PDGFR
T6920	ON123300		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
	ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11 nM).		FGFR , c-RET , JAK , CDK , PDGFR , Src , AMPK
T2372	Ponatinib	AP24534	VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
	Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively).		VEGFR , FGFR , Bcr-Abl , PDGFR , Src , c-Kit , Autophagy
T23127	PD-161570	PD 161570	EGFR , FGFR , PDGFR , Src
	PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, a...		EGFR , FGFR , PDGFR , Src
T6479	Dovitinib lactate hydrate	Dovitinib (TKI258) Lactate,Dovitinib Lactate,TKI258	VEGFR , FGFR , FLT , PDGFR , c-Kit
	Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) R...		VEGFR , FGFR , FLT , PDGFR , c-Kit
T6082	SSR128129E	SSR	FGFR
	SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.		FGFR
T2642	PD173074		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for FGFR1 than PDGFR and c-Src.		Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
T22306	DGY-06-116		FGFR , Src
	DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.		FGFR , Src
TQ0015	PRN1371		c-Fms , FGFR , CSF-1R
	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).		c-Fms , FGFR , CSF-1R
T37426	FIIN-1	FGFR irreversible inhibitor-1	FGFR
	FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2,...		FGFR
T3726	Erdafitinib	JNJ-42756493	Apoptosis , FGFR
	Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.		Apoptosis , FGFR
T4318	EOC317	ACTB-1003,ACTB1003,ACTB 1003	VEGFR , FGFR , Tie-2
	EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).		VEGFR , FGFR , Tie-2