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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36841 | IPI-9119 | Fatty Acid Synthase | |
IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM). | |||
T61820 | Ar-V7-IN-1 | ||
Ar-V7-IN-1 is a highly potent inhibitor specifically targeting Ar-V7, a splice variant of the androgen receptor that exhibits hormone-independent behavior. Its development shows promise for researching various indication... | |||
T74410 | PROTAC AR-V7 degrader-1 | ||
PROTAC AR-V7 degrader-1 (Compound 6) is an orally bioavailable, potent, and selective degrader targeting the androgen receptor (AR) variant V7, achieving degradation with a DC50 of 0.32 µM by directing the VHL E3 ligase ... | |||
T60019 | VPC-70063 | Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)- | Apoptosis , PARP , c-Myc |
VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C do... | |||
T36375 | Ralaniten triacetate | ||
Ralaniten triacetate (EPI-506) is a novel pro-drug of Ralaniten, functioning as an orally active inhibitor of the androgen receptor (AR) N-terminal domain (NTD). Its remarkable first-in-class status signifies its unique ... | |||
T9005 | VPC-80051 racemate | Others | |
VPC-80051 is the first small molecule inhibitor of hnRNP A1 splicing activity by using a computer-aided drug discovery approach. | |||
T79465 | Anticancer agent 135 | Androgen Receptor | |
Anticancer agent 135 (compound 26h) acts as a potent androgen receptor (AR) antagonist, effectively blocking AR nuclear translocation and inhibiting AR/AR-V7 heterodimerization to suppress downstream gene transcription. ... | |||
T78811 | PROTAC AR-NTD degrader 1 | Androgen Receptor | |
PROTAC AR-NTD antagonist 1 (compound 18) is a small molecule belonging to the protein-targeting chimeras (PROTACs) that selectively targets the N-terminal domain (AR-NTD) of the Androgen Receptor variant AR-V7. By antago... | |||
T74744 | MTX-23 | ||
MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducing apoptosis [1]. | |||
T79156 | (R)-SKBG-1 | Androgen Receptor | |
(R)-SKBG-1 is an inhibitor of the RNA-binding protein NONO, effectively downregulating androgen receptor expression by targeting both AR-FL mRNA and AR-V7 mRNA, with inhibition concentration (IC50) values of 3.1 μM and 5... | |||
T78810 | BWA-522 | Androgen Receptor | |
BWA-522 is a small molecule, orally available protein-targeting chimera (PROTAC) that potentates the degradation of both full-length androgen receptor (AR-FL) and the AR-V7 splice variant. It specifically antagonizes the... | |||
T78945 | WCA-814 | Androgen Receptor | |
WCA-814, an androgen receptor (AR) antagonist-Hsp90 inhibitor conjugate, induces degradation of both full-length and AR-V7, exhibiting cytotoxic effects in prostatic cancer cells with half maximal inhibitory concentratio... | |||
T39071 | Thailanstatin D | ||
Thailanstatin D, an analogue of Thailanstatin A, inhibits AR-V7 gene splicing by disrupting the interaction between U2AF65 and SAP155, hindering their binding to the polypyrimidine tract situated between the branch point... |