-pia

TH-162, also known as (R)-PIA and Adenosine, N-(1-methyl-2-phenylethyl)-, (R)-, is an agonist of the A1 adenosine receptor. Affinity for adenosine receptors is approx. 100× that of the (+)-isomer.

α-Conotoxin PIA TFA is an nAChR (nicotinic acetylcholine receptor) antagonist that primarily targets nAChR subtypes containing α6 and α3 subunits, exhibiting significantly higher selectivity for α6/α3β2β3 nAChR than α3β2 nAChR, and may be used for Parkinson's disease and schizophrenia.

Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).

α-Conotoxin PIA acetate is an antagonist of nicotinic acetylcholine receptor (nAChR) mainly targeting α6 and α3 subunits.

Daurinoline is a non-competitive antagonist, it exerts marked relaxation effect on basilar artery of rabbits through non-competitive antagonism, it would have a protective function on microcirculation of cerebral pia mater, which may be beneficial to relieve cerebral ischemic injury. Daurinoline could significantly reverse noradrenaline induced constriction of pial arterioles and venules, and increase the number of blood vessels which were decreased by noradrenaline.

1-O-Octadecyl-2-O-methyl-sn-glycerol is a metabolite of a phosphotidylinositol ether lipid analog (PIA). PIAs are known to target the pleckstrin homology domain of the serine/threonine kinase Akt and to induce apoptosis in cancer cell lines with high levels of endogenous Akt activity.

Hepcidin-20 (human), a peptide characterized by its histidine content, cysteine-rich composition, and β-sheet structure, exhibits antifungal properties. Furthermore, it effectively inhibits biofilm formation and disrupts the metabolism of bacterial cells in both polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains [1] [2] [3].