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Natural Product Categories Natural Product Categories Proteales
Proteales is an order of flowering plants that includes families such as Proteaceae, Nelumbonaceae, and Platanaceae, representing a wide range of ecological strategies from aquatic lotus to woody shrubs. Members of Proteales produce diverse secondary metabolites including flavonoids, alkaloids, tannins, and unique phenolic derivatives. In biomedical research, Proteales is significant due to the pharmacological properties of species like Nelumbo nucifera (lotus), which exhibit antioxidant, anti-inflammatory, neuroprotective, and cardioprotective activities. The order is also important for evolutionary studies because it spans aquatic and terrestrial adaptations, offering insight into how metabolic pathways diversify across extreme ecological transitions.
- (-)-AnonaineTN13931862-41-5In house(-)-Anonaine can be extracted from several species of Magnoliaceae and Annelidae and has antimalarial, antibacterial, antifungal, antioxidant, anticancer, antidepressant and vasodilatory activities. (-)-Anonaine induces apoptosis in human cervical cancer (HeLa) cells, induces DNA damage and inhibits the growth and migration of human lung cancer h1299 cells through Bax and caspase-dependent pathways.
- $1,400
SizeQTY - Astragalinkaempferol-3-glucoside, Kaempferol 3-β-D-glucopyranoside, Kaempferol 3-O-glucoside, Kaempferol 3-D-glucoside, Astragaline, 3-GlucosylkaempferolT6S1101480-10-4Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.
- $30
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Cited - LiensinineT5S10992586-96-11. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.
- $47
SizeQTY - Neferine(R)-1,2-Dimethoxyaporphine, (-)-NeferineT5S10972292-16-21. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.
- $43
SizeQTY - IsoliensinineIsoliensininT5S11036817-41-0Isoliensinine (Isoliensinin) is a natural product, a bisbenzylisoquinoline alkaloid. Isoliensinine has antitumor, antioxidant, anti-inflammatory, and antiarrhythmic activities.
- $30
SizeQTY Cited - 23-Hydroxybetulinic acidAnemosapogeninT3S215285999-40-223-Hydroxybetulinic acid (Anemosapogenin) shows potent anti-tumor effect in vivo, but it has some toxicity, structure modification should be needed.
- $31
SizeQTY - NuciferineVLT 049, Sanjoinine E, (-)-NuciferineT3369475-83-2Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.
- $39
SizeQTY - Roemerine(-)-RoemerineTN2160548-08-3Roemerine ((-)-Roemerine) is a porphyrin alkaloid from Senegalese lychee with antifungal and anticancer activity that prevents berberine efflux through inhibition of Bmr. Roemerine increases cell membrane permeability in a concentration-dependent manner and has been used in studies of fungal infections and prostate cancer.
- $98
SizeQTY - N-MethylnuciferineTWS0704754919-24-9N-Methylnuciferine is an alkaloid derived from Lotus Plumule that ameliorates lipopolysaccharide-induced depressive-like behavior.
- $90
SizeQTY - LirinidineTN187354383-28-7Lirinidine is an alkaloid isolated from L. tulipifera leaves with antioxidant and anticancer properties. It exhibits moderate iron-reducing capacity and small free radical scavenging capacity in vitro and can be used in cosmetic research.
- $72
SizeQTY - Liensinine diperchlorateLiensinine-PerchlorateT4S11025088-90-4Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as anti-arrhythmic, anti-hypertensive, anti-pulmonary fibrosis, and vascular smooth muscle relaxation.
- $30
SizeQTY - Liensinine PerchlorateT30552385-63-9Liensinine is the active constituent of plumula nelambinis with anti-hypertension.
- $55
SizeQTY Cited - O-NornuciferineTN10923153-55-7O-Nornuciferine reveals distinct in vitro hERG blockages measured in HEK293 cells with the IC50 value of 2.89 uM.
- $81
SizeQTY - DehydronuciferineTN10917630-74-2Dehydronuciferine, isolated from the leaves of Nelumbo nucifera Gaertn, exhibits acetylcholinesterase inhibition with an IC50 of 25 µg/mL.
- $65
SizeQTY - Olivetol5-Pentylresorcinol, 5-n-AmylresorcinolT3736500-66-3Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.
- $30
SizeQTY - 8-(1,1-Dimethyl-2-propenyl)-3'-methoxykaempferolTN55211859979-00-28-(1,1-Dimethyl-2-propenyl)-3'-methoxykaempferol is an isoprenylated kaempferol derivative extracted from fresh pak choi buds with anticancer and antitumor activity.8-(1,1-Dimethyl-2-propenyl)-3'- 8-(1,1-Dimethyl-2-propenyl)-3'- methoxykaempferol showed antiproliferative activity and cytotoxicity in human breast cancer (MCF-7) and human hepatocellular carcinoma (Hep-G2) cell lines.
- $829
SizeQTY - 1,2-DimethylnaphthaleneT207098573-98-81,2-Dimethylnaphthalene is a specific dimethylnaphthalene isomer carrying methyl substituents at the 1 and 2 positions on the naphthalene ring system, and this polycyclic aromatic hydrocarbon has been reported as a natural constituent in several plant species including Phaseolus vulgaris, Nelumbo lutea, and Magnolia liliiflora.
- $195
SizeQTY - 11-Dehydroxygrevilloside BTN2581197307-49-611-Dehydroxygrevilloside B is a natural product for research related to life sciences. The catalog number is TN2581 and the CAS number is 197307-49-6.
- $590
SizeQTY - (+)-Armepavine(S)-ArmepavineT2924314400-96-5(+)-Armepavine is an active compound from Nelumbo nucifera that exhibits anti-inflammatory effects on human peripheral blood mononuclear cells, immunosuppressive effects on T lymphocytes, and protective activity in lupus nephritic mice, in part by inhibiting TNF-α-induced MAPK and NF-κB signaling pathways.
- $372
SizeQTY - 2-Hydroxy-1-MethoxyaporphineTN121033770-27-32-Hydroxy-1-Methoxyaporphine can inhibit CYP2D6 activity, it also increase the glucose consumption significantly as rosiglitazone.
- $77
SizeQTY - (-)-N-methylcoclaurineN-MethylcoclaurineTN46135096-70-8N-Methylcoclaurine shows binding affinities for the ĸ opioid receptor with the equilibrium dissociation constant (Ki) value of 0.9 ± 0.1 uM. N-methylcoclaurine also shows promising butyrylcholinesterase inhibition activities, with the IC50 value of 1
- $758
SizeQTY - N-NornuciferineTQ02964846-19-9N-Nornuciferine is an aporphine alkaloid derived from lotus leaf that strongly inhibits CYP2D6 with an IC50 of 3.76 μM and Ki of 2.34 μM, and pharmacokinetic studies show rapid absorption into blood with mean Cmax values of 1.71 μg/mL at 0.9 h and 0.57 μg/mL at 1.65 h after administration. Following intravenous dosing at 10 mg/kg, N-Nornuciferine exhibits a wide volume of distribution of 9.48–15.17 L/kg and slow elimination half-lives of 2.09–3.84 h. the oral bioavailability of N-Nornuciferine is estimated at 58.13–79.91%. At 20 mg/kg i.v. dosing, N-Nornuciferine also rapidly crosses the blood–brain barrier, achieving unbound Cmax values of 0.32 μg/mL and 0.16 μg/mL at approximately 0.89–1.22 h.
- $71
SizeQTY - NorarmepavineTN46643195-01-5N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa
- $620
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