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Natural Product Categories Natural Product Categories Melanthiaceae
Melanthiaceae is a family of monocot flowering plants within the order Liliales, containing genera such as Veratrum. These plants are rich in steroidal alkaloids, saponins, and phenolic compounds, many of which exhibit strong biological activity. In biomedical research, Melanthiaceae is significant due to its potent cytotoxic, anticancer, and neurotoxic properties, making it important in both pharmacology and toxicology studies. Some compounds are investigated for anticancer drug development, while others serve as valuable tools for studying ion channel and neurological regulation mechanisms.
- Resveratroltrans-Resveratrol, SRT 501T1558501-36-0Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
- $36
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Cited - Pennogenin 3-O-beta-chacotriosideT816655916-52-4Pennogenin 3-O-beta-chacotrioside, isolated from *Paris polyphylla*, exhibits anti-colorectal cancer activity by modulating autophagy through increased expression of autophagy-related proteins LC3 and Beclin-1.
- $59
SizeQTY - Polyphyllin IT389550773-41-6Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
- $52
SizeQTY Cited - JervineJerwiny, Iervin, 11-KetocyclopamineT3363469-59-0The biological activity of Jervine (Jerwiny) is mediated via its interaction with the 7 passes transmembrane protein Smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the Hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and Hedgehog target genes cannot be transcribed.
- $64
SizeQTY - Polyphyllin VIT6S231555916-51-31. Polyphyllin VI has hemostasis , expectorant , bacteriostasis, anticytotoxic, anti pregnancy kill sperm effects.
- $33
SizeQTY Cited - Formosanin CPolyphyllin BT351950773-42-7Formosanin C (Polyphyllin B) is a compound isolated from Rhizoma Paridis, showed pro-apoptosis and immunoregulation with antitumor activity in cultured cells and animal systems.
- $64
SizeQTY Cited - Polyphyllin GY-0166T342576296-75-8Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas, including lung cancer, breast cancer, colorectal cancer, cervical cancer, hepatocellular carcinoma and osteosarcoma.
- $349
SizeQTY - Zingiberen newsaponinZingiberensis saponin ITN232991653-50-8Zingiberen newsaponin is a steroidal saponin from Dioscorea zingiberensis.
- $93
SizeQTY - Diosgenin glucosideTrillin, DisoglusideT387414144-06-0Diosgenin glucoside (Trillin) and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.
- $55
SizeQTY - VeratramineNSC23880, NSC17821T336460-70-8Veratramine (NSC-23880)(NSC-17821; NSC-23880) is a potent signal transduction inhibitor for treating tumors.
- $40
SizeQTY - VelutinT381625739-41-7Velutin shows the strongest inhibitory effect in NF-κB activation and exhibits the greatest effects in blocking the degradation of inhibitor of NF-κB as well as in inhibiting mitogen-activated protein kinase p38 and JNK phosphorylation. Velutin has anti-inflammatory property. Velutin exhibits the greatest potency among all flavones which reduce TNF-α and IL-6 production.
- $113
SizeQTY - Polyphyllin IIChonglou Saponin IIT389476296-72-5Polyphyllin II (Chonglou Saponin II) has hemostasis, expectorant, bacteriostasis, anticytotoxic, anti-pregnancy kill sperm effects.
- $32
SizeQTY - PseudojervineO-beta-D-Glucopyranosyljervine, Jervin-3-glucosideTN234336069-05-3Pseudojervine (O-beta-D-Glucopyranosyljervine) is derived from Veratrum nigrum L. Pseudojervine exhibits feeble inhibition activity against platelet aggregation.
- $58
SizeQTY - Polyphyllin HTN101081917-50-2Polyphyllin H can be extracted from loblolly pine and rhizomes, has antitumor activity, and is used in studies of inflammation, fractures, and convulsions.
- $74
SizeQTY - Oxyresveratroltrans-Oxyresveratrol, Tetrahydroxystilbene, 2,3',4,5'-tetrahydroxystilbeneT3S106829700-22-91. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.
- $31
SizeQTY - trans-TrimethoxyresveratrolTri-O-methylresveratrol, Trimethoxystilbene, trans-trismethoxy Resveratrol, MR-3, E-Resveratrol Trimethyl Ether, 3,4',5-Trimethoxy-trans-stilbeneT333022255-22-7trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.
- $30
SizeQTY - Veratric acidVeratrumenoic acid, 3,4-Dimethoxybenzoic acidT374493-07-2Veratric acid (3,4-Dimethoxybenzoic acid) is a benzoic acid derivative from plants and fruits, possessing antioxidant, anti-inflammatory, and blood pressure-lowering properties.
- $29
SizeQTY - 3,4-Dimethoxyphenylacetic acidHomoveratrumic acid, homoveratric acidT056893-40-33,4-Dimethoxyphenylacetic acid (Homoveratrumic acid) is the papaverine intermediate, used to synthesis cardiovascular drugs.
- $29
SizeQTY - 2,3-Dimethoxybenzaldehydeo-Veratraldehyde, 5,6-DimethoxybenzaldehydeT297586-51-12,3-Dimethoxybenzaldehyde (5,6-Dimethoxybenzaldehyde) is a benzoic acid analog, with high Antifungal activity (MIC=2.5 mM). 2,3-Dimethoxybenzaldehyde could be used for the synthesis of berberine.
- $29
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- VeratrosineVeratramine-beta-D-glucoside, Veratramine 3-glycosideTN1057475-00-3Veratrosine (Veratramine-beta-D-glucoside) is an alkaloid isolated from the herbs of Veratrum nigrum. Veratrosine exhibits feeble inhibition activity against platelet aggregation.
- $139
SizeQTY - Ergosta-7,22-dien-3-oneTN398332507-77-0Ergosta-7,22-dien-3-one is a lanosterane that can be isolated from the substrates of Ganoderma taiwanensis. It exhibits pro-inflammatory properties, stimulating nitric oxide production, inducing gene expression, and promoting the production of TLRs, cytokines, chemokines, and cellular adhesion molecules.
- $1,168
SizeQTY - PennogeninT2S2321507-89-1Pennogenin steroidal saponins could be utilized to develop anticancer medicines.
- $123
SizeQTY - Polyphyllin FTN481576296-74-7Polyphyllin F is a natural product of Paris, Liliaceae. The catalog number is TN4815 and the CAS number is 76296-74-7. Polyphyllin F can be used as a reference standard.
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