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Thrombopoietin Receptor

The thrombopoietin receptor also known as the myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110) is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene.

  • Butyzamide
    T678941110767-45-7In house
    Butyzamide is an effective and oral Mpl activator. It is a novel non-peptide-based molecule with antagonistic effects on thrombopoietin (TPO) receptors, which promotes proliferation of human Mpl (hMpl) expression and mouse pro B cell line Ba/F3. The phosphorylation of JAK2, STAT3, STAT5 and MAPK is induced. Butyzamide has been shown to help increase platelet levels in mouse xenotransplantation trials.
    • $285
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  • Avatrombopag
    T7417570406-98-3
    Avatrombopag (YM477) is a new oral thrombopoietin (TPO) receptor agonist, activating TPO receptor and increasing megakaryocytic proliferation/differentiation and platelet production.
    • $59
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  • 4”-O-Glucosylvitexin
    T388276135-82-5
    4”-O-Glucosylvitexin (glucosylvitexin) inhibits TPO activity.
    • $36
    In Stock
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  • Lusutrombopag
    TQ02231110766-97-6
    Lusutrombopag (Mulpleta) is an orally bioavailable, small molecule thrombopoietin (TPO) receptor agonist for chronic liver disease (CLD) patients with thrombocytopenia prior to elective invasive surgery.
    • $68
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