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Membrane transporter/Ion channel

Monoamine Transporter

(15)

Monocarboxylate transporter

Na-K-Cl cotransporter

Piezo Channel

PIEZO1 is a mechanosensitive ion channel protein that in humans is encoded by the gene PIEZO1. PIEZO1 is expressed in the lungs, bladder and skin, where mechanosensation has important biological roles. Unlike PIEZO2 which is highly expressed in sensory dorsal root ganglia, PIEZO1 is not expressed in sensory neurons. Consequently, PIEZO1 plays a significant role in multiple neurobiological processes including axon regeneration, neural stem cells differentiation and neurological disease progression.

Filter Signaling PathwaysMembrane transporter/Ion channelPiezo Channel

GsMTx4 TFA (1209500-46-8 free base)
TP1300
GsMTx4 TFA (1209500-46-8 free base) (GsMTx4 TFA) is a spider venom peptide that selectively inhibits cationic permeable mechanically-sensitive channels (MSCs) belonging to the Piezo and TRP channel families.
- $468
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Yoda 1
T7506448947-81-7
Yoda1 is a Piezo1 ion channel agonist (EC50s = 17.1 and 26.6 μM for murine and human Piezo1-transfected HEK293T cells, respectively)
- $39
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D-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia/reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.
- $710
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