IGF-1R

The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 (IGF-1) and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults – meaning that it can induce hypertrophy of skeletal muscle and other target tissues. Mice lacking the IGF-1 receptor die late in development, and show a dramatic reduction in body mass, testifying to the strong growth-promoting effect of this receptor.

Cat. No.	Product name	CAS No.	Purity
TN4675	Nortrachelogenin	34444-37-6	98%
TN4675	Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
T6003	GSK1904529A	1089283-49-7	98%
T6003	GSK1904529A is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T14142	AGL-2263	638213-98-6	98%
T14142	AGL-2263 is a blocker of insulin receptor (IR)
T24398	Lenaldekar	418800-15-4	98%
T24398	Lenaldekar is a T-cell expansion and autoimmune encephalomyelitis inhibitor.
T2349	BMS-754807	1001350-96-4	98%
T2349	Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine ...
T9980	AVJ16		98%
T9980	AVJ16 as a member of the insulin growth factor 2 mRNA-binding protein family, binds to the mRNA of certain genes to regulate protein translation.
T21761	HNMPA	132541-52-7	98%
T21761	HNMPA is an inhibitor of insulin receptor tyrosine kinase and inhibits the serine and tyrosine autophosphorylation of human insulin receptor.
TN7108	Urolithin C	165393-06-6	98%
TN7108	Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
TP1125	Insulin(cattle)	11070-73-8
TP1125	Insulin cattle (Insulin from bovine pancreas) is a two-chain polypeptide hormone produced in vivo in the pancreatic β cells。It has often been used as growth supp...
T9030	SU4984	186610-89-9	100%
T9030	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
TP2209L	Xenin 8 acetate		95.54%
TP2209L	Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family. Xenin 8 acetate augments Arginine-induced insulin release (by 40%)...
T13564L	AZ7550 hydrochloride	2309762-40-9	97.07%
T13564L	AZ7550 hydrochloride, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T3059	ALK-IN-1	1197958-12-5	97.66%
T3059	AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. P...
T6S1487	Ginsenoside Rg5	186763-78-0	98%
T6S1487	1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production a...
T2755	Rhoifolin	17306-46-6	98.11%
T2755	Rhoifolin is extracted from Turpinia arguya Seem dried leaves.
T2642	PD173074	219580-11-7	98.21%
T2642	PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for ...
T3079	GSK1838705A	1116235-97-2	98.89%
T3079	GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to ...
T17267	XL228	898280-07-4	98.92%
T17267	XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T2085	PQ401	196868-63-0	99.13%
T2085	PQ401 suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).