Cat. No. | Product name | CAS No. | Purity | Chemical Structure |
---|---|---|---|---|
T80605 | Dusigitumab | 1204390-13-5 | 98% |
Dusigitumab
|
Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody targeting the insulin-like growth factors IGF2 and IGF1, offering therapeutic potential for condition... | ||||
T80871 | Veligrotug | 2728655-31-8 | 98% |
Veligrotug
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Veligrotug is a chimeric monoclonal antibody of the IgG1-kappa class that targets the insulin-like growth factor 1 receptor (IGF1R, CD221) [1]. | ||||
T37589L | GIP (3-42), human acetate | 98% |
|
|
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolism in... | ||||
T14142 | AGL-2263 | 638213-98-6 | 98% |
|
AGL-2263 is a blocker of insulin receptor (IR) | ||||
TN4997 | Serpentine | 18786-24-8 | 98% |
|
Serpentine is an alkaloid found in the roots of Rosa Centifolia that acts as an insulin sensitizer to assist insulin in lowering blood glucose.Serpentine activat... | ||||
T37589 | GIP (3-42), human | 1802086-25-4 | 98% |
|
GIP (3-42), human (Gastric Inhibitory Polypeptide (3-42) (human)) is a peptide that acts as a glucose-dependent proinsulinotropic polypeptide (GIP) receptor anta... | ||||
T1791L | Ceritinib dihydrochloride | 1380575-43-8 | 99.99% |
|
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and ... | ||||
T4324 | PQ401 hydrochloride (196868-63-0(free base)) | T4324 | 99.9% |
|
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM. | ||||
T8906 | NBI-31772 | 374620-70-9 | 99.83% |
|
NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-respo... | ||||
T6079 | NVP-ADW742 | 475488-23-4 | 99.79% |
|
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and... | ||||
T77624 | WAY-270250 | 852367-46-5 | 99.77% |
|
WAY-270250 is an IGF-1R/SRC inhibitor. | ||||
T67707 | Tyrphostin AG 538 | 133550-18-2 | 99.73% |
|
Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive. | ||||
T60055 | Chromeceptin | 331859-86-0 | 99.72% |
|
Chromeceptin is an inhibitor of the IGF signaling pathway, decreases the numbers of tumorsphere, and inhibits the AKT/mTOR pathway. | ||||
T8773 | MID-1 | 312608-54-1 | 99.61% |
|
MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes ... | ||||
T3S0027 | Picropodophyllotoxin | 17434-18-3 | 99.57% |
|
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insuli... | ||||
T6080 | NVP-AEW541 | 475489-16-8 | 99.55% |
|
NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based as... | ||||
T3386 | Kaempferitrin | 482-38-2 | 99.51% |
|
Kaempferitrin (Lespenephryl) has antidepressant-like effect related to the serotonergic system, principally 5-HT1A. Kaempferitrin exerts cytotoxic and antitumor ... | ||||
T1791 | Ceritinib | 1032900-25-6 | 99.46% |
|
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM). | ||||
T2607 | MSDC 0160 | 146062-49-9 | 99.45% |
|
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. | ||||
T6943 | Picropodophyllin | 477-47-4 | 99.41% |
|
Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulate... |