Cart
Autophagy CXCR

CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions. The intracellular second loop is a site that is coupled to a heterotrimeric G-protein and has a characteristic aspartate-arginine-tyrosine box amino acid sequence.
Cat No. product name
T15805L LY2510924 acetate(1088715-84-7 free base) Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
T4163 Repertaxin Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CX...
TQ0174 AMD-070 Mavorixafor (AMD-070) is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tr...
T7681 AZD-5069 AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
T5849 JMS-17-2 JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
T7130 Navarixin Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in...
T5207 LIT927 LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
T5193 Danirixin Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
T3992 MSX122 MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
T4032 MSX127 MSX-127 elicites positive response in peptide CXCR4.
T4033 MSX130 MSX-130 is CXCR4 Antagonist.
T2477 UNBS5162 UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
T12269L NUCC-390 dihydrochloride (1060524-97-1 free base) NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
T3327 Arteether Arteether is a new, fast-acting antimalarial drug.
T1739 WZ811 WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
T1955 SB225002 SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
T1776L Plerixafor 8HCl (AMD3100 8HCl) AMD 3100 octahydrochloride blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (H...
T0801 Tannic acid Tannic acid is a novel hERG channel blocker.
T6764 ATI2341 ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
T3047 SRT3109 SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T3396 Baohuoside I Baohuoside I is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
T1776 Plerixafor Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
TP1348 FC131 TFA (606968-52-9 free base) FC131 TFA is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity.
T12269 NUCC-390 NUCC-390 is a selective agonist of small-molecule CXCR4 receptor.
T6764L ATI-2341 acetate(1337878-62-2 free base) ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein ...
T19385 ITIC-4F ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithieno...
T7208 AMD 3465 hexahydrobromide AMD 3465 hexahydrobromide is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
T14665L Motixafortide TFA(664334-36-5,Free) Motixafortide is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via alter...
T22565 AMD-070 hydrochloride AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.
TN5227 (+/-)-Vestitol Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T17208 USL311 USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation an...
T16933 SRT3190 SRT3190 is an antagonist of CXCR2.
T16864 SCH 563705 SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T16850 SB-265610 SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizati...
T19386 ITIC ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an ind...
T13324 VUF11207 fumarate VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
T10905 CXCR2-IN-1 CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T10635 Burixafor hydrobromide Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
TP2141 Balixafortide TFA (1051366-32-5 free base) Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T11179 Elubrixin Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as ...
T11140 E6130 E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T12705 Reparixin L-lysine salt Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
T14665 Motixafortide Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L Balixafortide Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T10297L AMG 487 AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of...
T8497 SX-682 SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
T7499 TAK-779 TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).
LY2510924 acetate(1088715-84-7 free base)
T15805LCAS T15805L
Ly2510924 acetate is an potent and selective CXCR4 antagonist. It prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM.
Repertaxin
T4163CAS 266359-83-5
Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CX...
AMD-070
TQ0174CAS 558447-26-0
Mavorixafor (AMD-070) is a selective and orally available CXCR4 antagonist (IC50: 13 nM against CXCR4 125I-SDF binding) and also inhibits the replication of T-tr...
AZD-5069
T7681CAS 878385-84-3
AZD-5069 is an chemokine receptor 2 antagonist (CXCR2; IC50 = 0.79 nM).
JMS-17-2
T5849CAS 1380392-05-1
JMS-17-2 is a potent and selective antagonist of CX3CR1( IC50 : 0.32 nM).
Navarixin
T7130CAS 473727-83-2
Navarixin(SCH527123) is a novel, selective CXC chemokine receptor 2(CXCR2) antagonist that inhibits neutrophil activation and modulates neutrophil trafficking in...
LIT927
T5207CAS 2172879-52-4
LIT-927 is an orally active CXCL12 neutraligand (Ki: 267 nM for CXCL12 binding to CXCR4).
Danirixin
T5193CAS 954126-98-8
Danirixin is a potent antagonist of CXCR2 that inhibits IL-8 binding to CXCR2 (IC50: 12.5 nM).
MSX122
T3992CAS 897657-95-3
MSX-122 is a novel small molecule and partial CXCR4 antagonist, with potent inhibition of CXCR4/CXCL12 actions(IC50 = 10 nM).
MSX127
T4032CAS 6616-56-4
MSX-127 elicites positive response in peptide CXCR4.
MSX130
T4033CAS 4051-59-6
MSX-130 is CXCR4 Antagonist.
UNBS5162
T2477CAS 956590-23-1
UNBS-5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.
NUCC-390 dihydrochloride (1060524-97-1 free base)
T12269LCAS T12269L
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
Arteether
T3327CAS 75887-54-6
Arteether is a new, fast-acting antimalarial drug.
WZ811
T1739CAS 55778-02-4
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
SB225002
T1955CAS 182498-32-4
SB225002 is a potent and selective CXCR2 antagonist inhibiting interleukin IL-8 binding to CXCR2.
Plerixafor 8HCl (AMD3100 8HCl)
T1776LCAS 155148-31-5
AMD 3100 octahydrochloride blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (H...
Tannic acid
T0801CAS 1401-55-4
Tannic acid is a novel hERG channel blocker.
ATI2341
T6764CAS 1337878-62-2
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
SRT3109
T3047CAS 1204707-71-0
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
Baohuoside I
T3396CAS 113558-15-9
Baohuoside I is a component of Epimedium koreanum, exhibits anti-inflammatory activity and anti-osteoporosis activities.
Plerixafor
T1776CAS 110078-46-1
Plerixafor, a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.
FC131 TFA (606968-52-9 free base)
TP1348CAS TP1348
FC131 TFA is an antagonist of CXCR4 that inhibits the binding of [125I] -sdf-1 to CXCR4(IC50 : 4.5 nM ), and has anti-hiv activity.
NUCC-390
T12269CAS 1060524-97-1
NUCC-390 is a selective agonist of small-molecule CXCR4 receptor.
ATI-2341 acetate(1337878-62-2 free base)
T6764LCAS T6764L
ATI-2341 acetate is an effective allosteric agonist of CXCR4, it activates Gα1 instead of Gα13. ATI-2341 acetate activates inhibitory heterotrimeric G protein ...
ITIC-4F
T19385CAS 2097998-59-7
ITIC-4F has broad applicability in high-efficiency binary and ternary single-junction as well as tandem polymer solar cells (PSCs).ITIC-4F is an indacenodithieno...
AMD 3465 hexahydrobromide
T7208CAS 185991-07-5
AMD 3465 hexahydrobromide is a CXCR4 receptor antagonist with potential anticancer and anti-HIV activity.
Motixafortide TFA(664334-36-5,Free)
T14665LCAS T14665L
Motixafortide is an antagonist of CXCR4 with IC50 of ~1 nM. It induces the apoptosis of AML blasts by down-regulating ERK, BCL-2, MCL-1 and cyclin-D1 via alter...
AMD-070 hydrochloride
T22565CAS 880549-30-4
AMD-070 hydrochloride is a CXCR4 antagonist, is useful for Anti HIV.
(+/-)-Vestitol
TN5227CAS 56701-24-7
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
USL311
T17208CAS 1373268-67-7
USL311 is a CXCR4 receptor antagonist which prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4. USL311 inhibits CXCR4 activation an...
SRT3190
T16933CAS 1204707-73-2
SRT3190 is an antagonist of CXCR2.
SCH 563705
T16864CAS 473728-58-4
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
SB-265610
T16850CAS 211096-49-0
SB-265610 is a nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilizati...
ITIC
T19386CAS 1664293-06-4
ITIC has a superior thermal stability and undergoes a glass-crystal transition considerably below its high Tg of 180 °C. ITIC, non-fullerene acceptor, is an ind...
VUF11207 fumarate
T13324CAS 1785665-61-3
VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).
CXCR2-IN-1
T10905CAS 1873376-49-8
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
Burixafor hydrobromide
T10635CAS 1191450-19-7
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
Balixafortide TFA (1051366-32-5 free base)
TP2141CAS TP2141
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
Elubrixin
T11179CAS 688763-64-6
Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as ...
E6130
T11140CAS 1427058-33-0
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
Reparixin L-lysine salt
T12705CAS 266359-93-7
Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
Motixafortide
T14665CAS 664334-36-5
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Balixafortide
TP2141LCAS 1051366-32-5
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
AMG 487
T10297LCAS 473719-41-4
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of...
SX-682
T8497CAS 1648843-04-2
SX-682 is a potent, selective and orally bioavailable inhibitor of CXCR1/2 ,has the potential to treat castration-resistant prostate cancer.
TAK-779
T7499CAS 229005-80-5
TAK-779 is an antagonist of chemokine receptor 5 (CCR5), CCR2b, and CXC chemokine receptor 3 (CXCR3).