CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.

Cat. No.	Product name	CAS No.	Purity
T10905	CXCR2-IN-1	1873376-49-8	98%
T10905	CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T68052	Delmetacin	16401-80-2	98%
T68052	Delmetacin is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine receptor CXCR1...
T25131	AZD8309	333742-48-6	98%
T25131	AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
T10635	Burixafor hydrobromide	1191450-19-7	98%
T10635	Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
T11140	E6130	1427058-33-0	98%
T11140	E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T16933	SRT3190	1204707-73-2	98%
T16933	SRT3190 is an antagonist of CXCR2.
T12269L	NUCC-390 dihydrochloride (1060524-97-1 free base)	T12269L	98%
T12269L	NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
TN5227	(+/-)-Vestitol	56701-24-7	98%
TN5227	Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T16864	SCH 563705	473728-58-4	98%
T16864	SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T19386	ITIC	1664293-06-4	98%
T19386	ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
T6764	ATI-2341	1337878-62-2	98%
T6764	ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
T19385	ITIC-4F	2097998-59-7	98%
T19385	ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
TP2141	Balixafortide TFA (1051366-32-5 free base)	TP2141	98%
TP2141	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T14665	Motixafortide	664334-36-5	98%
T14665	Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L	Balixafortide	1051366-32-5	98%
TP2141L	Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T0801	Tannic acid	1401-55-4	98%
T0801	Tannic acid is a novel hERG channel blocker.
T1739	WZ811	55778-02-4	98%
T1739	WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
T3047	SRT3109	1204707-71-0	98%
T3047	SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T0617	Nicotinamide N-oxide	1986-81-8	98%
T0617	Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzy...
T10297L	AMG 487	473719-41-4	98%
T10297L	AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of...