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CXCR

The CXCR signaling pathway family mainly comprises chemokines and chemokine receptors and CXCR consists of about 330 amino acids. The seven transmembrane regions divide the molecule into an extracellular free N-terminus, three extracellular loops, three intracellular loops, and several C-terminal portions.
Cat. No. Product name CAS No. Purity Chemical Structure
T10905 CXCR2-IN-1 1873376-49-8 98%
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
T68052 Delmetacin 16401-80-2 98%
Delmetacin is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine receptor CXCR1...
T25131 AZD8309 333742-48-6 98%
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
T10635 Burixafor hydrobromide 1191450-19-7 98%
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
T11140 E6130 1427058-33-0 98%
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
T16933 SRT3190 1204707-73-2 98%
SRT3190 is an antagonist of CXCR2.
T12269L NUCC-390 dihydrochloride (1060524-97-1 free base) T12269L 98%
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
TN5227 (+/-)-Vestitol 56701-24-7 98%
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
T16864 SCH 563705 473728-58-4 98%
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
T19386 ITIC 1664293-06-4 98%
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
T6764 ATI-2341 1337878-62-2 98%
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
T19385 ITIC-4F 2097998-59-7 98%
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
TP2141 Balixafortide TFA (1051366-32-5 free base) TP2141 98%
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
T14665 Motixafortide 664334-36-5 98%
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
TP2141L Balixafortide 1051366-32-5 98%
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
T0801 Tannic acid 1401-55-4 98%
Tannic acid is a novel hERG channel blocker.
T1739 WZ811 55778-02-4 98%
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
T3047 SRT3109 1204707-71-0 98%
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
T0617 Nicotinamide N-oxide 1986-81-8 98%
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzy...
T10297L AMG 487 473719-41-4 98%
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of...
CXCR2-IN-1
T10905
CXCR2-IN-1 has a pIC50 of 9.3 and is a CXCR2 antagonist of the central nervous system penetration agent.
Delmetacin
T68052
Delmetacin is a non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity and inhibitory effects on the CXC chemokine receptor CXCR1...
AZD8309
T25131
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas a...
Burixafor hydrobromide
T10635
Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent CXCR4 antagonist and an anti-angiogenic drug that is of potential value in tre...
E6130
T11140
E6130 may be effective in the treatment of inflammatory bowel disease and is a highly selective CX3CR1 regulator for oral administration.
SRT3190
T16933
SRT3190 is an antagonist of CXCR2.
NUCC-390 dihydrochloride (1060524-97-1 free base)
T12269L
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.
(+/-)-Vestitol
TN5227
Vestitol has antioxidation, anti-inflammatory and antimicrobial activities, it can strongly act in a low dose and concentration and have a promising potential to...
SCH 563705
T16864
SCH 563705 is an effective and orally available CXCR2 and CXCR1 antagonist (IC50s: 1.3 nM, 7.3 nM and Kis of 1 and 3 nM, respectively).
ITIC
T19386
ITIC, a non-fullerene acceptor, demonstrates exceptional thermal stability and exhibits a glass-crystal transition at a significantly lower temperature than its ...
ATI-2341
T6764
ATI-2341, pepducin targeting the C-X-C chemokine receptor type 4 (CXCR4), is an allosteric agonist activating the inhibitory heterotrimeric G protein (Gi) to pro...
ITIC-4F
T19385
ITIC-4F, an indacenodithienothiophene (IDTT)-based postfullerene electron acceptor, exhibits wide applicability in high-efficiency binary and ternary single-junc...
Balixafortide TFA (1051366-32-5 free base)
TP2141
Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large pane...
Motixafortide
T14665
Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).
Balixafortide
TP2141L
Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and prog...
Tannic acid
T0801
Tannic acid is a novel hERG channel blocker.
WZ811
T1739
WZ811 is a novel and effective small molecular CXCR4 antagonist (EC50: 0.3 nM).
SRT3109
T3047
SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
Nicotinamide N-oxide
T0617
Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzy...
AMG 487
T10297L
AMG 487 is a potent and selective antagonist of chemokine (C-X-C motif) receptor 3 (CXCR3) which inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of...
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