vinca

Vindoline is an indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly.

Vincamine (Perval) is a major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.

Vincantril is a type of Vinca alkaloid compound known for its anti-hypoxic properties.

Apovincamine is a vinca alkaloid and a chemical precursor of Vinpocetine, which is a derivative of Vincamine with vasodilating activity.

19-Hydroxypseudovincadifformine is a useful organic compound for research related to life sciences and the catalog number is T125260.

Vincanol is a potent voltage-gated Na+ channels blocker.

Vincamajine is a biochemical.

Apovincaminic acid hydrochloride salt, the primary active metabolite of Vinpocetine (VP), is orally active and has the ability to penetrate the brain. It demonstrates a neuroprotective mechanism of action [1][2].

Vincapusine is a natural inhibitor of 3C-like protease (3CLpro), targeting SARS-CoV-2 3CLpro, SARS-CoV 3CLpro and MERS-CoV 3CLpro.

Brovincamine also known as brovincamine fumarate (BV, Sabromin) was used in Japan mainly as an improver of cerebral circulation and metabolism, and also as an inhibitor of the aggregation of platelets through the cyclic AMP pathway in patients with normal tension glaucoma. Brovincamine exerts its action via calcium channels blockade. Brovincamine is also a vasodilator.

14,15-Didehydrovincamenine is a natural product for research related to life sciences. The catalog number is TN2620 and the CAS number is 112219-48-4.

16,17-Dihydroapovincamine is a natural product for research related to life sciences. The catalog number is TN2642 and the CAS number is 57130-30-0.

16-O-Methyl-14,15-didehydroisovincanol is a natural product for research related to life sciences. The catalog number is TN2649 and the CAS number is 112237-71-5.

Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).

Vinburnine (Eburnalritardo) is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.

Fluorocurarine chloride (Metvine; Vincanine methyl chloride) is a plant metabolite that can be isolated from the Vinca plant.

Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.

Vinconate, an indolonaphthyridine derivative, can stimulate the muscarinic acetylcholine receptor.

Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).

Desacetylvinblastine (4-Desacetylvinblastine) is a primary metabolite of vinblastine and functions as a cytotoxic agent. While its antitumor efficacy is limited when used alone, it can exhibit significant antitumor activity when involved as part of specific conjugates.

Vincristine binds to tubulin and inhibits the formation of microtubules, thereby inhibiting mitosis of the cancer cell. Vincristine can be used as a microtubule-destabilizing agent for research on the treatment of hematologic cancers, such as leukemia and

Thalicarpine is a natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent.

Vinorelbine (KW-2307 base) is a semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents the formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase.

Rescinnamine is an inhibitor of angiotensin-converting enzyme. It also is a vinca alkaloid obtained from Rauwolfia serpentina and other species of Rauwolfia. It used as an antihypertensive drug.