v-19

GV-196771A A novel NMDA receptor glycine site antagonist with potent antinociceptive activity.

19-Hydroxybaccatin V (compound 14), a diterpenoid derived from Taxus chinensis, holds potential in cancer research [1].

GV-196771 selectively antagonize the glycine-binding site of the NMDA ionophore.

Hemin (Hemin chloride) is a chlorinated iron-containing porphyrin, a heme oxygenase (HO)-1 inducer. Hemin has therapeutic activity in porphyrias by reducing heme deficiency in patients, thereby inhibiting δ-aminolevulinic acid synthetase activity through biochemical feedback.

MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.

Sildenafil chlorosulfonyl is a synthetic intermediate in the synthesis of the phosphodiesterase 5 (PDE5) inhibitor sildenafil .1It is also a potential impurity found in commercial preparations of sildenafil. 1.Nagaraju, V., Sreenath, D., Rao, J.T., et al.Separation and determination of synthetic impurities of sildenafil (Viagra) by reversed-phase high-performance liquid chromatographyAnal. Sci.19(7)1007-1011(2003)

Antibacterial agent 19 exhibits strong activity against K. pneumoniae, (M-R) S. aureus, and (M-R,V-R) S. aureus, demonstrating minimum inhibitory concentrations (MICs) of 0.022 mg mL for both K. pneumoniae and (M-R) S. aureus, and 0.045 mg mL for (M-R,V-R) S. aureus.