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Search Results for " transthyretin "

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T61423	Transthyretin-IN-1
	Transthyretin-IN-1 (Compound 1d) is a potent inhibitor of transthyretin (TTR) fibril formation, making it a valuable tool for investigating Alzheimer’s disease [1].
T39740	Acoramidis hydrochloride	AG10 hydrochloride,Alxn2060 hydrochloride	Others
	Acoramidis hydrochloride (Alxn2060 hydrochloride) is an orally active and selective kinetic stabilizer of WT and V122I- TTR (transthyretin) . Acoramidis hydrochloride is used in the study for transthyretin amyloidosis.		Others
T9447	AG-10	Acoramidis	Others
	AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis.		Others
T7582	Tafamidis meglumine	Fx-1006A	Others
	Tafamidis meglumine (Fx-1006A) is a Potent and Selective Transthyretin Kinetic Stabilizer That Inhibits the Amyloid Cascade		Others
T10203	A 1120		Others
	A 1120 is a nonretinoid retinol-binding protein 4 (RBP4) antagonist (Ki: 8.3 nM), which disrupts the interaction between RBP4 and its binding partner transthyretin.		Others
T4565	Tafamidis	Fx-1006A	Others
	Tafamidis (Fx-1006A) is a kinetic stabilizer of transthyretin (TTR) that prevents amyloidogenesis by wild-type and mutant TTRs. It binds to TTR with negative cooperativity (Kd1: 3 nM; Kd2: 278 nM) to stabilize the TTR di...		Others
T32500	L6Y	TTR stabilizer L6
	L6Y is a transthyretin (TTR) stabilizer which binds to the T4 binding pocket of TTR and prevents the dissociation of TTR to monomer.
T15116	Dichlorophenyl-ABA		Others
	Dichlorophenyl-ABA is a transthyretin (TTR) amyloid fibril formation inhibitor. It inhibits aggregate formation in more than 80% in TTR L55P-expressing cells.		Others
T79417	PITB
	PITB, a selective and orally active transthyretin (TTR) aggregation inhibitor, is utilized in transthyretin amyloidosis (ATTR) disease research [1].
T75173	WT-TTR inhibitor 1
	Compound 21, a WT-TTR (wild-type Transthyretin) inhibitor, exhibits a 29.05% inhibition rate at a concentration of 100 μM [1].
T38909	Inotersen sodium	ISIS-420915 sodium
	Inotersen sodium, also known as ISIS-420915 sodium, is a 2′-O-methoxyethyl-modified antisense oligonucleotide compound. It effectively inhibits transthyretin (TTR) protein production by targeting the TTR RNA transcript, ...
T39304	Vutrisiran	ALN-TTRsc02
	Vutrisiran (ALN-TTRsc02) is an investigational, liver-directed small interfering ribonucleic acid (siRNA) compound designed for research on transthyretin (TTR)-mediated amyloidosis.
T38918	Revusiran	ALN-TTRSC
	Revusiran (ALN-TTRSC) is a first-generation short interfering RNA (siRNA) that specifically targets transthyretin (TTR) mRNA. It is utilized in TTR-mediated amyloidosis research.
T71785	GUN35758
	GUN35758, also known as 4'-Carboxybenzo-18C6, is a novel transthyretin (ttr) amyloidogenesis inhibitor, stabilizing the ttr tetramer by binding to the allosteric sites on the molecular surface of the ttr tetramer. Thi...
T74405	PEG2000-C-DMG
	PEG2000-C-DMG, a pegylated lipid, facilitates the creation of Onpattro, a hepatically targeted investigational RNAi therapeutic. This agent effectively decreases the synthesis of both mutant and wild-type transthyretin b...
T38804	Patisiran sodium
	Patisiran sodium is a double-stranded small interfering RNA (siRNA) that selectively targets a specific sequence within the transthyretin (TTR) messenger RNA (mRNA). By doing so, it effectively blocks the hepatic synthes...
T74645	Eplontersen
	Eplontersen, a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide, targets transthyretin (TTR) mRNA to suppress the synthesis of both variant and wild-type TTR proteins. The accumulatio...

Compounds

Acoramidis hydrochloride

T39740

Synonym: AG10 hydrochloride,Alxn2060 hydrochloride

Synonym: TTR stabilizer L6

Synonym: ISIS-420915 sodium

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01756	Transthyretin Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Transthyretin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is E9KL36.
TMPY-04919	Transthyretin Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	Transthyretin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 13.6 kDa and the accession number is P07309.
TMPK-01090	Transthyretin/Prealbumin Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other functions have emerged, namely in th...
TMPH-02947	Transthyretin Protein, Mouse, Recombinant	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13....
TMPH-02946	Transthyretin Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Transthyretin Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. Th...
TMPH-02242	Transthyretin Protein, Human, Recombinant (hFc & Myc)	Human	HEK293 Cells
	Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
TMPJ-00084	RBP4 Protein, Human, Recombinant	Human	E. coli
	Retinol Binding Protein 4 (RBP4) is a member of the Lipocalin family and in the blood. RBP4 is the specific vector for retinol. RBP4 is expressed and secreted by adipose tissue, and is associated with insulin resistance....