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Results for "

tankyrase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    35
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    1
    TargetMol | Recombinant_Protein
msc2504877
3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
T600981460286-21-8
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4 6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phospho-Rb.
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Tankyrase-IN-2
T130781588870-36-3
Tankyrase-IN-2 is a selective, potent and orally active inhibitor of tankyrase with IC50s of 10, 7, and 710 nM for TNKS1, TNKS2 as well as PARP1, respectively
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6-8 weeks
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Tankyrase Inhibitors (TNKS) 49
T23419
Tankyrase Inhibitors 49 is an effective, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM).
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Tankyrase Inhibitors (TNKS) 22
T23420
Tankyrase Inhibitors 22 is a potent, selective, and orally bioavailable inhibitor of tankyrase (IC50: 0.1nM).
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tankyrase-in-4
T72847
Tankyrase-IN-4 is a potent inhibitor of tankyrase 1 (TNKS1), exhibiting an IC50 of 0.8 nM, and is utilized in cancer research.
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6-8 weeks
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Tankyrase-IN-5
T790261460285-69-1
Tankyrase-IN-5 (Compound 30f), structurally related to MSC2504877, effectively inhibits tankyrase isoforms TNKS1 and TNKS2 with IC50 values of 2.3 nM and 7.9 nM, respectively [1].
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8-10 weeks
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Olaparib
KU0059436, AZD2281
T3015763113-22-0
Olaparib (KU0059436) is a small molecule inhibitor of PARP1 PARP2 (IC50=5 1 nM), with weak inhibitory activity against PARP tankyrase-1 (IC50=1.5 μM), and is selective and orally active. Olaparib exhibits autophagy and mitochondrial autophagy activation activity.
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TargetMol | Inhibitor Hot
Niraparib
MK-4827
T32311038915-60-4
Niraparib (MK-4827) is a PARP inhibitor that selectively targets PARP1 and PARP2 (IC50=3.8 2.1 nM), exhibiting antitumor activity, inhibiting DNA damage repair, and inducing apoptosis.
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Niraparib tosylate monohyrate
T94971613220-15-7
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
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XAV-939
XAV939, NVP-XAV939
T1878284028-89-3
XAV-939 (NVP-XAV939) is a Tankyrase (TNKS) inhibitor that inhibits TNKS1 and TNKS2 (IC50=11 4 nM). XAV-939 selectively inhibits Wnt β-catenin-mediated transcription.
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RK-287107
T167612171386-10-8
RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).
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exo-IWR-1
exo-IWR 1
T227751127442-87-8
exo-IWR-1 (exo-IWR 1) is an inactive stereoisomer of Endo-IWR-1,and is a negative control of IWR-1. IWR-1 is a tankyrase inhibitor which inhibits Wnt β-catenin signaling pathway.
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MN-64
MN64
T316892831-11-3
MN-64 is a tankyrases inhibitor, showed 6 nM potency against tankyrase 1, isoenzyme selectivity, and Wnt signaling inhibition.
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K-756
T15639130017-40-2
K-756 is a direct and selective inhibitor of tankyrase (TNKS), inhibiting the ADP-ribosylation activity of TNKS1 [IC50 = 31 nM] and TNKS2 [IC50 = 36 nM].
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6-8 weeks
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JW 55
JW55
T1807664993-53-7
JW 55 (JW55) is an effective and selective β-catenin signaling pathway inhibitor, works by inhibition of the PARP domain of tankyrase 1 and tankyrase 2 (TNKS1 2).
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G-631
T2000851507370-78-6
G-631 acts as a selective tankyrase inhibitor, effectively hindering tankyrase auto-PARsylation (poly ADP ribosylation) at an IC 50 of 7 nM and suppressing the Wnt signaling pathway. This compound also demonstrates favorable pharmacokinetic properties in mice.
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4-6 weeks
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EXQ-2d
T205739
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.
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TC-E 5001
T23428865565-29-3
dual tankyrase (TNKS) inhibitor
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6-8 weeks
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tnks-in-41
TNKS inhibitor-41, TNKS inhibitor 41, TNKS IN 41
T248911584646-59-2
TNKS-IN-41 highly potent and selective inhibitor of tankyrase.
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6-8 weeks
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TNKS-IN-1
T2898959455-93-5
TNKS-IN-1 is a highly potent and selective inhibitor of tankyrase.
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6-8 weeks
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WIKI4
T3062838818-26-1
WIKI4 is a potent inhibitor of Wnt β-catenin signaling and tankyrase 2 (TNKS2).
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Niraparib hydrochloride
MK-4827 hydrochloride, MK-4827 (hydrochloride)
T33531038915-64-8
Niraparib hydrochloride (MK-4827 hydrochloride) is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. By inhibiting PARP activity, niraparib hydrochloride increases DNA strand breaks, leading to genomic instability and apoptosis. The PARP family of proteins detects and repairs single-strand DNA breaks via the base-excision repair (BER) pathway.
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CAY10753
T36702
CAY10753 is an inhibitor of tankyrase 2 (TNKS2; IC50= 0.3 nM).1It is selective for TNKS2 over TNKS1 (IC50= 6.1 nM), as well as poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (IC50s = 89.6 and 37.8 nM, respectively). CAY10753 inhibits proliferation of DLD-1 colorectal cancer cells when used at a concentration of 1 μM. 1.Tomassi, S., Pfahler, J., Mautone, N., et al.From PARP1 to TNKS2 inhibition: A structure-based approachMed. Chem. Lett.(2020)
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om-1700
T628692406276-78-4
OM-1700 is a potent inhibitor of tankyrase, acting on tankyrase 1 (IC50: 127 nM) and tankyrase 2 (IC50: 14 nM). OM-1700 inhibits the growth of colon cancer cell lines and inhibits COLO 320DM cells (GI50: 650 nM).
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8-10 weeks
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