tαt1

Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression.

SAHA chloroalkane T1 is a novel compound formed by combining Vorinostat (SAHA) with a chloroalkane capture tag, referred to as T1. This innovative approach involves tethering the SAHA molecule with the T1 tag, resulting in the formation of SAHA chloroalkane T1.

Ribonuclease T1 (Rnase T1), widely utilized in biochemical research, is an endonuclease targeting single-stranded RNA. It cleaves the phosphodiester bond between 3'-guanosine residues and adjacent nucleoside 5'-OH groups, thereby producing 3'-GMP terminal oligonucleotides, and forms nucleoside 2', 3'-cyclic phosphoric acid intermediates in the process [1].

Ganoderic acid T1, a deacetylated derivative of Ganoderic acid T, diminishes mitochondrial membrane potential and triggers cell apoptosis by activating caspase-9 and caspase-3, thus impairing the antioxidant defense system of cancer cells. Additionally, it elevates intracellular ROS levels, yielding pro-oxidant activities and cytotoxicity [1].

CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apoptosis. This compound diminishes CDK9 transcriptional activity and downregulates phosphorylation of RNA Pol II CTD ser2. In vivo, CDK9-Cyclin T1 PPI-IN-1 effectively impedes tumor growth in a TNBC 4T1 mouse model [1].

Polymyxin T1 is an antibiotic produced by Bacillus polymyxa (E-12) that is effective against Gram-negative bacteria, while its efficacy against Gram-positive bacteria is relatively weaker.

Dextran T1 (MW 1,000) is a polymer of anhydrous glucose with an average molecular weight of 1000. It exhibits excellent biodegradability and biocompatibility, making it suitable for use in the fields of food, pharmaceuticals, cosmetics, and research.

Urolithin A is a natural product, a metabolite of ellagic acid, which inhibits DNA synthesis and induces apoptosis and autophagy. Urolithin A exhibits antioxidant, anti-inflammatory and antitumor activities.

Cethromycin (ABT-773) is an antibiotic of ketolide.

JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein.

Ambamustine HCl is a novel tripeptide anticancer.

HTHQ (HTHQ(1-O-Hexyl-2,3,5-trimethylhydroquinone)), a hydroquinone monoalkyl ether, is an effective anti-oxidative agent. HTHQ is a potent anti-lipid-peroxidative compound and its antioxidation activity to be extremely elevated in biological systems, such as that of liver microsomes via the generation of stable free radicals.

IACS-9439 is a potent, selective, and orally active CSF1R inhibitor with a K(i) of 1 nM, suitable for research on advanced solid tumors [1].

TT-10 (TAZ-K), an activator of YES-associated protein (YAP)-transcriptional enhancer factor domain (TEAD) activity, has potential application in heart disease research, specifically for conditions characterized by loss of cardiomyocytes.

SOR-C13 is an inhibitor of transient receptor potential cation channel vanilloid family member 6 (TRPV6, CaT1 or CATL) with potential antineoplastic activity. TRPV6 calcium channel inhibitor SOR-C13 binds to TRPV6 and prevents the influx of calcium ions into TRPV6-expressing tumor cells. This inhibits the activation of nuclear factor of activated T-cell (NFAT) transcription complex which may result in an inhibition of calcium-dependent cancer cell proliferation and an induction of apoptosis in tumor cells overexpressing TRPV6.

TT15 is an agonist of the GLP-1R.

DC-S100 is a selective histone methyltransferase SET7 inhibitor.

Astegolimab (RG 6149) is a humanised IgG2 monoclonal antibody that targets the IL-33 receptor and inhibits IL-33 signalling. Astegolimab is used in the study of chronic obstructive pulmonary disease (COPD) and severe asthma in adults.

Azenosertib (ZN-c3) is an orally active, specific GPR119 agonist. Azenosertib (ZN-c3) stimulates cell proliferation and improves pancreatic β-cell function. [1]

UKTT15 (compound 6) functions as an allosteric inhibitor of PARP1 [1].

The LinTT1 peptide is a tumor-penetrating peptide with the amino acid sequence AKRGARST. It targets peritoneal cancer (PC) by binding to the p32 (gC1qR) receptor. The LinTT1 can associate with iron oxide nanohelical (NWs) structures to form a nanocarrier that is taken up by peritoneal cancer cells in vitro and penetrates mitochondria; it also shows significant tumor-targeting and penetration effects in vivo in mice. Furthermore, LinTT1-functionalized nanocarriers combined with the pro-apoptotic peptide [D(KLAKLAK)2] demonstrate substantial tumor inhibition in a mouse peritoneal tumor model. LinTT1 peptide holds promise as a delivery vehicle for peritoneal cancer research.