sc 10

SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.

Chk2 inhibitor,ATP-competitive

NSC 105204 is a bioactive chemical.

NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 is a potent cyclin-dependent kinase 9(CDK9) inhibitor that inhibits multiple myeloma tumors growth and induces apoptosis [1].

Aspartame (SC-18862), an artificial, non-carbohydrate sweetener, is aspartyl-phenylalanine-1-methyl ester.

MSA-2 dimer, a selective and orally active non-nucleotide STING agonist with a dissociation constant (Kd) of 145 μM, demonstrates prolonged antitumor and immunogenic activity. It non-covalently binds to STING as a dimer, showing greater permeability compared to cyclic dinucleotide[1].

Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many congenital myasthenia syndromes, par

SML-10-70-1 is a Novel Active Site Inhibitor of Oncogenic K-Ras G12C.