s1pr1

S1PR1 modulator 1 is a selective inhibitor of S1PR1, with a pIC50 of 7.6.

SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.

Mocravimod hydrochloride (KRP-203) is an effecitive and orally active agonist of sphingosine 1-phosphate receptor type 1(S1PR1).

W146 is a selective and potent Sphingosine 1-phosphate receptor subtype 1 (S1PR1) antagonist that induces significant but transient hematolymphopenia in mice.W146 induces significant but transient hematolymphopenia in mice, inducing pulmonary edema.

FTY720 (S)-Phosphate is the active stereoisomeric phosphate derivative of FTY720 that acts as a potent modulator of sphingosine-1-phosphate (S1P) receptors. FTY720 (S)-Phosphate binds to S1P receptor subtypes S1P1, S1P3, S1P4, and S1P5 with Ki values of 2.1, 5.9, 23, and 2.2 nM respectively, causing receptor internalization on lymphocytes， preventing S1P-mediated lymphocyte egress from lymphoid tissues. FTY720 (S)-Phosphate also enhances endothelial barrier integrity, stimulates transporters such as Abcb1 and Abcc1, and inhibits cytosolic phospholipase A2 activity, highlighting its multifunctional pharmacological properties, making it an compound of interest in the research of diseases including multiple sclerosis, autoimmune diseases and cancer.

NIBR-0213 is a potent and selective competitive S1P1 antagonist with activity against experimental autoimmune encephalomyelitis. In the GTPγ35S assay, it has IC50 values ​​of 2.0 nM and 2.3 nM for human and rat S1P1, respectively.

S1PR1 agonist3 (Compound Y18) is a highly selective S1PR1 receptor agonist with an EC50 of 0.98 nM. It holds promise for research into autoimmune diseases such as multiple sclerosis and ulcerative colitis.

S1PR1/S1PR5 agonist-1 (Compound 19) is an orally active agonist for S1PR1 and S1PR5, with EC50 values of 40.0 and 22.9 nM, respectively. It interacts with essential residues of S1PR1 to mediate agonist activity. S1PR1/S1PR5 agonist-1 effectively alleviates colitis pathology in a DSS-induced mouse model with minimal impact on heart rate, making it useful for research in inflammatory bowel disease.

S1PR1 agonist 2 is a potent activator of S1PR1 with potential applications in autoimmune disease research.

S1PR1 agonist 1 is a potent activator of S1PR1 with potential applications in autoimmune diseases.

S1PR-MO-1 is a modulator of sphingosine-1-phosphate receptor and is used to study hyperproliferative inflammatory diseases.

Fingolimod hydrochloride (FTY720) , a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).

Ex26 (S1P1-IN-Ex26) is a selective and potent sphingosine 1-phosphate receptor 1 (S1P1) antagonist that disrupts SR-B1-S1PR1 interactions and inhibits S1P-S1PR1 signaling. Ex26 is used in experimental autoimmune encephalomyelitis, atherosclerosis, and gastric cancer.

Ponesimod (ACT-128800) is an orally available sphingosine-1-phosphate receptor 1 (S1PR1, S1P1) agonist with potential immunomodulating activity.

Vibozilimod (SCD-044) is S1P receptor-1 (S1PR1) agonist .

W146 TFA is a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1), exhibiting an EC50 value of 398 nM.

VPC03090 is a Sphingosine-1-Phosphate Receptor Inhibitor. VPC03090 is an analog of FTY-720, acts as antagonist for S1PR1 and S1PR3. VPC03090-P, converted from VPC03090 through the phosphorylation by SK-2, causes a reduction in tumor growth in mice with mammary cancer, and its oral bioavailability is determined to be 30 hours.

RP101442, the active metabolite of Ozanimod, is a selective and potent agonist of the sphingosine-1-phosphate receptor 1 (S1PR1), displaying EC50 values of 2.6 nM for S1PR1 and 171 nM for S1PR5.

RP101988, the principal active metabolite of Ozanimod, is a potent and selective agonist for sphingosine-1-phosphate receptor 1 (S1PR1), exhibiting half-maximal effective concentrations (EC50s) of 0.19 nM for S1PR1 and 32.8 nM for S1PR5.

FTY720 (S)-Phosphate, an S1P receptor 1 (S1PR1) agonist, is utilized in studying acute inflammatory diseases, including acute lung injury.

KSI-6666 is an orally effective competitive antagonist of sphingosine 1-phosphate receptor 1 (S1PR1), with an IC50 value of 6.4 nM. It exhibits anti-inflammatory activity in models of autoimmune encephalomyelitis and T-cell transfer-induced colitis.

Fingolimod-D4 hydrochloride is a deuterated compound of Fingolimod hydrochloride (T2539). Fingolimod hydrochloride has a CAS number of 162359-56-0. Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).

Fingolimod-D4 Hcl (Standard) is a reference standard of Fingolimod-D4 Hcl intended for quantitative analysis, quality control, and related biochemical research applications. Fingolimod-d4 HCl is a deuterated compound of Fingolimod HCl. Fingolimod HCl has a CAS number of 162359-56-0. Fingolimod, a novel immune modulator, is a sphingosine 1-phosphate (S1P) antagonist (IC50: 0.033 nM in K562 and NK cells).