Search Result

Search Results for " pro-apoptotic "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T21919	UCF 101		Apoptosis
	UCF 101 is a specific inhibitor of HtrA2 and reduces apoptosis in PC12 cells.		Apoptosis
T76371	Tumor targeted pro-apoptotic peptide
	The compound, tumor-targeted pro-apoptotic peptide (CNGRC-GG-D(KLAKLAK)2), functions as an anti-tumor agent by disrupting mitochondrial membranes to induce apoptosis, demonstrating anticancer efficacy in mice [1].
T23861	CAY10526	CAY-10526,BTH,CAY 10526	Prostaglandin Receptor
	CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway.		Prostaglandin Receptor
T12870	SCH79797 dihydrochloride		Apoptosis , Others , Protease-activated Receptor
	SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.		Apoptosis , Others , Protease-activated Receptor
T77662	DJ4		Apoptosis
	DJ4 induces a dose-dependent pro-apoptotic effect in the micromolar range.		Apoptosis
T13689	Ethylene dimethanesulfonate		Apoptosis
	Ethylene dimethanesulfonate has selective pro-apoptotic effects on LCs. Ethylene dimethanesulfonate is a mild alkylating, non-volatile methanesulfonic diester of ethylene glycol.		Apoptosis
T4212	XMU-MP-1		Hippo pathway
	XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.		Hippo pathway
T12644L	(S)-Thalidomide	(S)-(-)-Thalidomide	Apoptosis
	(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-isomer of Thalidomide with immunomodulatory, anti-inflammatory, anticancer, anti-angiogenic and pro-apoptotic activities, and is used in the study of leprosy erythema nodosu...		Apoptosis
T77571	Bcl-B inhibitor 1		Apoptosis , BCL
	Bcl-B inhibitor 1 is a Bcl-B inhibitor with antitumor activity that binds to and inactivates pro-apoptotic proteins in the BH3 structural domain.		Apoptosis , BCL
T9726	2’-OMe-Guanosine		Apoptosis , Nucleoside Antimetabolite/Analog
	2'-OMe-Guanosine is a modified nucleoside produced by the action of tRNA guanosine-2'-o-methyltransferase. 2'-OMe-Guanosine has a certain pro-apoptotic effect.		Apoptosis , Nucleoside Antimetabolite/Analog
T77332	TV 3279		BCL , PKC
	TV 3279 is a novel ChE-MAI inhibitor , and the neuroprotective properties depend on their ability to induce the anti-apoptotic proteins PKC, Bcl-2, Bcl-x, and SOD, and to block the nuclear translocation of the pro-apopto...		BCL , PKC
T70388	(S)-Enitociclib	VIP152	CDK
	(S)-Enitociclib (VIP152) is a selective CDK9 inhibitor that induces complete regression of MYC+ lymphomas by inhibiting RNA polymerase II-mediated transcription of anti-apoptotic and pro-survival proteins.		CDK
T10827	CK2/ERK8-IN-1	TMCB	Apoptosis , ERK , Casein Kinase , Pim , DYRK
	CK2/ERK8-IN-1 (TMCB) is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1, DYRK1A, and HIPK2 (Kis: 8.65 µM, 11.9 µM, and 15.25...		Apoptosis , ERK , Casein Kinase , Pim , DYRK
T31020	CP 461	OSI 461,UNII-68OJX9I7DT,CP-461,CP461	Apoptosis , PDE
	CP 461 (UNII-68OJX9I7DT), a specific PDE2A inhibitor, is a novel pro-apoptotic compound that inhibits cyclic GMP phosphodiesterase but not cyclooxygenase-1 or -2. CP 461 inhibits the growth of a variety of human tumor ce...		Apoptosis , PDE
T10706	CCI-006		Mitochondrial Metabolism
	CCI-006, a selective inhibitor and chemosensitizer for MLL-rearranged leukemia cells, disrupts mitochondrial respiration. This action leads to irreversible mitochondrial depolarization and triggers a pro-apoptotic unfold...		Mitochondrial Metabolism
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE
T6778	BDA-366		BCL
	BDA-366, a potent Bcl2 antagonist, selectively binds the Bcl2-BH4 domain with high affinity (Ki = 3.3 nM), inducing a conformational change that nullifies its antiapoptotic function, thereby transforming it into a pro-ap...		BCL
T21911	Rilmenidine hemifumarate	Rilmenidine (hemifumarate),S-3341 hemifumarate	Apoptosis , Imidazoline Receptor
	Rilmenidine hemifumarate (S-3341 hemifumarate) is a novel, orally active and selective I1 imidazoline receptor and α2-adrenoceptor agonist that induces autophagy, regulates the proliferation of leukaemia cells, stimulate...		Apoptosis , Imidazoline Receptor
T60202	MMRi62	7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol	Ferroptosis
	MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...		Ferroptosis
T34335	RM-133	RM133
	RM-133 is a promising pro-apoptotic agent which shows activity on various cancer cell lines.
T36901	Pelcitoclax
	Pelcitoclax (APG-1252) is a powerful inhibitor of the Bcl-2 and Bcl-xl proteins, displaying significant antineoplastic and pro-apoptotic properties[1].
TP1611	Bim BH3, Peptide IV
	This Bim peptide belongs to the pro-apoptotic group of the Bcl-2 family of proteins.
T26789	BH3I-2'	BH3I2',BH3I 2'
	BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the in...
T80038	Bim BH3
	Bim BH3 is a bioactive peptide that belongs to the pro-apoptotic Bcl-2 family of proteins.
T29060	UNBS-1450	UNBS 1450,UBS1450,UBS-1450,UBS 1450
	UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomol...
TP1718	Bim BH3, Peptide IV TFA (721885-31-0 free base)	Bim BH3, Peptide IV TFA
	Bim BH3, Peptide IV TFA is a 26-site residue of BH3 protein Bim, belonging to the pro-apoptotic group of bcl-2 protein family.
T68027	(Z/E)-cp-461 free base
	CP-461 is an orally bioavailable second-generation selective apoptotic antineoplastic drug (SAAND) and analog of the nonsteroidal anti-inflammatory drug (NSAID) sulindac, with potential pro-apoptotic and antineoplastic a...
T11534L	Haemanthamine hydrochloride (466-75-1 free base)	Haemanthamine hydrochloride	Others
	Haemanthamine hydrochloride is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-ap...		Others
T35270	YO-Pro 1	YO-Pro1,YO-Pro-1
	YO-Pro 1, a cyanine dye consisting of benzoxazole and quinoline rings connected by a linker, is almost nonfluorescent in water, but its fluorescence is greatly enhanced after intercalation in double-stranded DNA, forming...
T76030	Bim BH3, Peptide IV TFA
	Bim BH3, Peptide IV TFA, is a 26-residue peptide derived from the BH3-only protein Bim, a member of the pro-apoptotic Bcl-2 protein family [1] [2].
T69296	PHA-680626
	PHA-680626 is a potent and selective PLK inhibitor. PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of bot...
T71301	Opaganib HCl
	ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitivel...
T76073	BH3 hydrochloride
	BH3 hydrochloride, a peptide that crosses the blood-brain barrier, induces apoptosis either through direct activation of the pro-apoptotic proteins Bax/Bak or by inhibiting anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, B...
T70008	Bomedemstat ditosylate
	Bomedemstat, also known as IMG-7289, is a lysine-specific histone demethylase 1 (LSD1) inhibitor with antineoplastic activity. Bomedemstat may be useful in the treatment of acute myeloid leukaemia, myelodysplastic syndro...
T76315	HKPao
	HKPao (Hunter-killer peptide ao) is a biologically active peptide with dual functionality, exhibiting anti-obesity and anti-tumor pro-apoptotic activities. It induces the release of cytochrome c from vesicles, thereby pl...
T63757	Bcl-2-IN-9
	Bcl-2-IN-9 is a novel, pro-apoptotic, low cytotoxic Bcl-2 inhibitor (IC50: 2.9 μM). Bcl-2-IN-9 downregulates Bcl-2 expression, induces apoptosis in cancer cells, and exhibits high selectivity for leukemia cells.
TP1965	Parstatin(human)	Parstatin (human)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 3 μM), and induces cell cycle arrest. Promotes activation...
TP1966	Parstatin(mouse)	Parstatin (mouse)
	Cell-permeable peptide cleaved from protease-activated receptor 1 (PAR1) upon receptor activation. Attenuates endothelial cell migration and proliferation (IC50 ~ 20 μM), and induces cell cycle arrest. Promotes activatio...
T72570	Antitumor agent-83
	Antitumor agent-83 acts as a BAX pro-apoptotic protein activator, significantly inhibiting tumor cell proliferation and mediating cell apoptosis through BAX's conformational activation. It also impedes the A549 cell cycl...
T28874	SU11652	SU-11652,SU 11652
	SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF...
T38042	Resolvin D4	Resolvin D4,RvD4
	Resolvin D4 (RvD4) is a specialized pro-resolving mediator derived from docosahexaenoic acid . [1] It has been detected in human milk, in the dorsal pouch of mice before and after infection with S. aureus, and in untreat...
T37166	RCTR1
	Resolvin conjugate in tissue regeneration 1 (RCTR1) is a specialized pro-resolving mediator (SPM) biosynthesized from docosahexaenoic acid by isolated human macrophages and apoptotic polymorphonuclear (PMN) neutrophils.1...
T83751	PUMA BH3 (human) TFA
	PUMA BH3, a peptide that includes the BH3 domain from the p53-upregulated modulator of apoptosis (PUMA) and activates the pro-apoptotic protein Bak, demonstrates binding affinity to Bak with dissociation constants (Kds) ...
T68656	Brivudine monophosphate
	Brivudine monophosphate is a phosphate ester of Brivudine. Brivudine, also known as bromovinyl-deoxyuridine, is a uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bro...
T38043	Resolvin E4
	Resolvin E4 (RvE4) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.1It is produced from eicosapentaenoic acid by 15-lipoxygenase (15-LO)via15(S)-HpEPE and 15S-hydroxy, 5S-HpEPE inte...
T79919	S-Adenosyl-L-methionine (1,4-butanedisulfonate)	Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)	Endogenous Metabolite
	S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-pr...		Endogenous Metabolite
T80226	R8 Bid BH3
	r8 Bid BH3, a biologically active peptide, is a pro-apoptotic member of the "BH3-only" subset within the BCL-2 family proteins, pivotal in regulating apoptosis. This compound exhibits lethality towards Bcl-2-expressing h...
T64158	Nenocorilant
	Nenocorilant (Relacorilant) is an orally active glucocorticoid receptor (GR) antagonist (Ki: 0.15 nM). Nenocorilant can be used to study tumours.
T80224	Bid BH3 (80-99)
	Bid BH3 (80-99) is a biologically active peptide known as a pro-apoptotic member of the 'BH3-only' (BOPS) subset within the BCL-2 protein family, pivotal in apoptosis regulation. It notably interacts with Bcl-2, Bax, and...
T36410	9(E),11(E),13(E)-Octadecatrienoic Acid
	9(E),11(E),13(E)-Octadecatrienoic acid (β-ESA) is a conjugated polyunsaturated fatty acid that is found in plant seed oils and in mixtures of conjugated linolenic acids synthesized by the alkaline isomerization of linole...

Compounds

Tumor targeted pro-apoptotic peptide

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

SCH79797 dihydrochloride

T12870

Synonym:

Target: Apoptosis, Others, Protease-activated Receptor

Ethylene dimethanesulfonate

Target: Hippo pathway

(S)-Thalidomide

T12644L

Synonym: (S)-(-)-Thalidomide

Target: Apoptosis, BCL

2’-OMe-Guanosine

T9726

Synonym:

Target: Apoptosis, Nucleoside Antimetabolite/Analog

Target: Apoptosis, ERK, Casein Kinase, Pim, DYRK

CP 461

T31020

Synonym: OSI 461,UNII-68OJX9I7DT,CP-461,CP461

Target: Apoptosis, PDE

CCI-006

T10706

Synonym:

Target: Mitochondrial Metabolism

Rilmenidine hemifumarate

T21911

Synonym: Rilmenidine (hemifumarate),S-3341 hemifumarate

Target: Apoptosis, Imidazoline Receptor

MMRi62

T60202

Synonym: 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol

Synonym: BH3I2',BH3I 2'

Synonym: UNBS 1450,UBS1450,UBS-1450,UBS 1450

Target:

Bim BH3, Peptide IV TFA (721885-31-0 free base)

TP1718

Synonym: Bim BH3, Peptide IV TFA

Target:

(Z/E)-cp-461 free base

T68027

Synonym:

Target:

Haemanthamine hydrochloride (466-75-1 free base)

T11534L

Synonym: Haemanthamine hydrochloride

Target: Others

YO-Pro 1

T35270

Synonym: YO-Pro1,YO-Pro-1

Target:

Bim BH3, Peptide IV TFA

Bomedemstat ditosylate

Synonym: Parstatin (human)

Target:

Parstatin(mouse)

TP1966

Synonym: Parstatin (mouse)

Synonym: SU-11652,SU 11652

Target:

Resolvin D4

T38042

Synonym: Resolvin D4,RvD4

Brivudine monophosphate

S-Adenosyl-L-methionine (1,4-butanedisulfonate)

T79919

Synonym: Ademetionine (1,4-butanedisulfonate),S-Adenosyl methionine (1,4-butanedisulfonate),AdoMet (1,4-butanedisulfonate)

Target: Endogenous Metabolite

9(E),11(E),13(E)-Octadecatrienoic Acid

T36410

Synonym:

Target:

Cat No.	Product Name	Synonyms	Targets
T8193	α-Thujone	Thujone,ALPHA-(-)-THUJONE	Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
	α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
T13903	Stearoylethanolamide	N-(2-Hydroxyethyl)octadecanamide	Apoptosis
	Stearoylethanolamide(N-(2-Hydroxyethyl)octadecanamide) is a cannabinoid compound present in the brains of humans, rats, and mice with pro-apoptotic activity.		Apoptosis
T13864	Resolvin D1	RvD1	Apoptosis
	Resolvin D1 (RvD1) is an endogenous pro-inflammatory mediator that blocks pro-inflammatory neutrophil migration by regulating actin polymerization, reduces TNF-α-mediated inflammation in macrophages, and enhances macroph...		Apoptosis
T3395	Timosaponin AIII	Filiferin B,AneMarsaponin A3,Timosaponin A3	AChE , mTOR
	Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC...		AChE , mTOR
T5679	(E)-Ferulic acid	trans-Ferulic acid,(E)-Coniferic acid	BCL , Ferroptosis , Wnt/beta-catenin , Endogenous Metabolite
	(E)-Ferulic acid ((E)-Coniferic acid) causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pr...
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
T36715	Tetrac	Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis , EGFR
	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...		Apoptosis , EGFR
TCS2170	2,5-Dihydroxyacetophenone	Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP	ERK , NF-κB , Tyrosinase
	1. 2,5-Dihydroxyacetophenone (Quinacetophenone) possess anti-anxiety, and neuroprotective qualities. 2. 2,5-Dihydroxyacetophenone (Quinacetophenone) reatment can induce a sustained activation of JNK, ERK1/2, and p38 MAPK...		ERK , NF-κB , Tyrosinase
T11534	Haemanthamine		Others
	Haemanthamine is an alkaloid isolated from the Amaryllidaceae plants with potent anticancer activity. It inhibits protein biosynthesis during the elongation stage of translation. It has antimalarial, pro-apoptotic, antiv...		Others
TMA1743	Ergosterol peroxide		ERK , VEGFR , p38 MAPK , Wnt/beta-catenin , Akt , JAK , CDK , JNK , STAT , Antifection
	Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Foxo3a activity by inhibiting pAKT and c-Myc and activating pr...
TN1543	Cynaropicrin		IL Receptor , Others , TNF
	Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as...		IL Receptor , Others , TNF
T73813	Haemanthamine hydrochloride
	Haemanthamine hydrochloride, a crinine-type alkaloid derived from Amaryllidaceae plants, exhibits potent anticancer properties. It acts by targeting ribosomes, thereby inhibiting protein biosynthesis during the translati...
TMA0918	Neochamaejasmine A		Caspase
	Neochamaejasmin A can inhibit cellular (3)H-thymidine incorporation (IC 50 12.5 microg/mL) and subsequent proliferation of human prostate cancer LNCaP cells, it blocks cell cycle progression at the G1 phase by activating...		Caspase

Natural Products

α-Thujone

T8193

Synonym: Thujone,ALPHA-(-)-THUJONE

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Stearoylethanolamide

T13903

Synonym: N-(2-Hydroxyethyl)octadecanamide

Synonym: Filiferin B,AneMarsaponin A3,Timosaponin A3

Target: AChE, mTOR

(E)-Ferulic acid

T5679

Synonym: trans-Ferulic acid,(E)-Coniferic acid

Target: BCL, Ferroptosis, Wnt/beta-catenin, Endogenous Metabolite

Irigenin

T3862

Synonym:

Target: NF-κB, Integrin

Tetrac

T36715

Synonym: Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid

Target: Apoptosis, EGFR

2,5-Dihydroxyacetophenone

TCS2170

Synonym: Quinacetophenone,2-Acetylhydroquinone,2-5-dihydroxyacetophenone,Acetylhydroquinone,DHAP

Target: ERK, NF-κB, Tyrosinase

Target: ERK, VEGFR, p38 MAPK, Wnt/beta-catenin, Akt, JAK, CDK, JNK, STAT, Antifection

Cynaropicrin

TN1543

Synonym:

Target: IL Receptor, Others, TNF

Haemanthamine hydrochloride

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02700	BCL2 Protein, Human, Recombinant (His)	Human	E. coli
	BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis. It is a large protein family a...
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST)	Mouse	Baculovirus-Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is...
TMPY-00731	Cathepsin B Protein, Human, Recombinant (His)	Human	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPY-01356	S100A8 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation....
TMPY-00834	IGF1R/CD221 Protein, Human, Recombinant (His)	Human	HEK293
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPH-01548	IFI6 Protein, Human, Recombinant (B2M & His)	Human	E. coli
	Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towar...
TMPH-00535	Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)	EBV	E. coli
	Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic pro...
TMPK-00901	TYRO3 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPY-01561	PIG3 Protein, Human, Recombinant (His)	Human	E. coli
	Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of ca...
TMPK-00533	TYRO3 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew mac...
TMPH-01057	Caspase-8 Protein, Human, Recombinant (His)	Human	E. coli
	Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood...
TMPY-03974	Bim Protein, Human, Recombinant (His)	Human	E. coli
	BCL2L11, also known as Bim, belongs to the BCL-2 protein family. Members of this family form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. ...
TMPY-03434	BMF Protein, Human, Recombinant (His)	Human	E. coli
	BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BMF...
TMPJ-00584	Bc1-w Protein, Human, Recombinant (His)	Human	E. coli
	Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing thre...
TMPJ-01066	CYCS Protein, Human, Recombinant (His)	Human	E. coli
	Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a highly soluble protein that functions as...
TMPY-02578	DKKL1 Protein, Human, Recombinant (hFc)	Human	HEK293
	Dickkopf-like 1 (DKKL1) or soggy 1, is a glycoprotein unique to mammals that is expressed primarily in developing spermatocytes and localized in the acrosome of mature sperm. It is also expressed in the trophectoderm / p...
TMPY-02065	BID Protein, Mouse, Recombinant (His & GST)	Mouse	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPY-02027	BID Protein, Human, Recombinant	Human	E. coli
	The BH3 interacting domain death agonist (BID) is a pro-apoptotic member of the Bcl-2 protein family, which contains only the BH3 domain, and is required for its interaction with the Bcl-2 family proteins and for its pro...
TMPY-04930	Notch 2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	NOTCH2 (Notch Receptor 2) is a Protein Coding gene. This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of dev...
TMPY-04109	Galectin-7 Protein, Human, Recombinant (His)	Human	E. coli
	LGALS7, also known as Galectin-7, is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members of this family. Galectins share similaritie...
TMPH-01642	MELK Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25...
TMPY-02774	Galectin-7 Protein, Human, Recombinant (GST)	Human	E. coli
	LGALS7, also known as Galectin-7, is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members of this family. Galectins share similaritie...
TMPH-01802	NME4 Protein, Human, Recombinant (GST)	Human	E. coli
	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through...
TMPH-03264	P53 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPH-02574	P53 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr prote...
TMPH-01531	IKBKB Protein, Human, Recombinant (His)	Human	Baculovirus
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPH-01532	IKBKB Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. A...
TMPY-03556	S100A8 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	S100A8 is a member of the S100 protein family containing 2EF-hand calcium-binding motifs. S100 proteins are involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation....
TMPY-02144	Cathepsin B Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPH-00855	RPS3 Protein, Human, Recombinant (His)	Human	E. coli
	Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad spe...
TMPY-04503	Cathepsin B Protein, Rat, Recombinant (His)	Rat	HEK293
	Cathepsin B is a papain-family cysteine protease that is normally located in lysosomes, where it is involved in the turnover of proteins and plays various roles in maintaining the normal metabolism of cells. This proteas...
TMPH-01075	P53 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negativel...
TMPY-04360	IGF1R/CD221 Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPH-02876	RIPK1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Serine-threonine kinase which is a key regulator of TNF-mediated apoptosis, necroptosis and inflammatory pathways. Exhibits kinase activity-dependent functions that regulate cell death and kinase-independent scaffold fun...
TMPY-06195	IGF1R/CD221 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-06905	IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...

BCL2 Protein, Human, Recombinant (His)

TMPY-02700

Species: Human

Expression System: E. coli

MKK4 Protein, Mouse, Recombinant (His & GST)

TMPY-04572

Species: Mouse

Expression System: Baculovirus-Insect Cells

Cathepsin B Protein, Human, Recombinant (His)

TMPY-00731

Species: Human

Expression System: HEK293

S100A8 Protein, Human, Recombinant (His)

TMPY-01356

Species: Human

Expression System: Baculovirus-Insect Cells

IGF1R/CD221 Protein, Human, Recombinant (His)

TMPY-00834

Species: Human

Expression System: HEK293

IFI6 Protein, Human, Recombinant (B2M & His)

TMPH-01548

Species: Human

Expression System: E. coli

Epstein-Barr virus (strain B95-8) BHRF1 Protein (His)

TMPH-00535

Species: EBV

Expression System: E. coli

TYRO3 Protein, Mouse, Recombinant (His)

TMPK-00901

Species: Mouse

Expression System: HEK293

PIG3 Protein, Human, Recombinant (His)

TMPY-01561

Species: Human

Expression System: E. coli

TYRO3 Protein, Cynomolgus, Recombinant (His)

TMPK-00533

Species: Cynomolgus

Expression System: HEK293

Caspase-8 Protein, Human, Recombinant (His)

TMPH-01057

Species: Human

Expression System: E. coli

Bim Protein, Human, Recombinant (His)

TMPY-03974

Species: Human

Expression System: E. coli

BMF Protein, Human, Recombinant (His)

TMPY-03434

Species: Human

Expression System: E. coli

Bc1-w Protein, Human, Recombinant (His)

TMPJ-00584

Species: Human

Expression System: E. coli

CYCS Protein, Human, Recombinant (His)

TMPJ-01066

Species: Human

Expression System: E. coli

DKKL1 Protein, Human, Recombinant (hFc)

TMPY-02578

Species: Human

Expression System: HEK293

BID Protein, Mouse, Recombinant (His & GST)

TMPY-02065

Species: Mouse

Expression System: E. coli

BID Protein, Human, Recombinant

TMPY-02027

Species: Human

Expression System: E. coli

Notch 2 Protein, Human, Recombinant (His)

TMPY-04930

Species: Human

Expression System: Baculovirus-Insect Cells

Galectin-7 Protein, Human, Recombinant (His)

TMPY-04109

Species: Human

Expression System: E. coli

MELK Protein, Human, Recombinant (His & Myc)

TMPH-01642

Species: Human

Expression System: E. coli

Galectin-7 Protein, Human, Recombinant (GST)

TMPY-02774

Species: Human

Expression System: E. coli

NME4 Protein, Human, Recombinant (GST)

TMPH-01802

Species: Human

Expression System: E. coli

p53 Protein, Rat, Recombinant (His)

TMPH-03264

Species: Rat

Expression System: E. coli

p53 Protein, Mouse, Recombinant (His & SUMO)

TMPH-02574

Species: Mouse

Expression System: E. coli

PKC iota Protein, Human, Recombinant (GST)

TMPY-04455

Species: Human

Expression System: Baculovirus-Insect Cells

IKBKB Protein, Human, Recombinant (His)

TMPH-01531

Species: Human

Expression System: Baculovirus

IKBKB Protein, Human, Recombinant (E. coli, His)

TMPH-01532

Species: Human

Expression System: E. coli

S100A8 Protein, Mouse, Recombinant (His)

TMPY-03556

Species: Mouse

Expression System: E. coli

Cathepsin B Protein, Mouse, Recombinant (His)

TMPY-02144

Species: Mouse

Expression System: HEK293

RPS3 Protein, Human, Recombinant (His)

TMPH-00855

Species: Human

Expression System: E. coli

Cathepsin B Protein, Rat, Recombinant (His)

TMPY-04503

Species: Rat

Expression System: HEK293

p53 Protein, Human, Recombinant (His & SUMO)

TMPH-01075

Species: Human

Expression System: E. coli

IGF1R/CD221 Protein, Human, Recombinant (His & GST)

TMPY-04360

Species: Human

Expression System: Baculovirus-Insect Cells

RIPK1 Protein, Mouse, Recombinant (His)

TMPH-02876

Species: Mouse

Expression System: E. coli

IGF1R/CD221 Protein, Mouse, Recombinant (His)

TMPY-06195

Species: Mouse

Expression System: HEK293

IGF1R/CD221 Protein, Human, Recombinant (His & Avi), Biotinylated

TMPY-06905

Species: Human

Expression System: HEK293

Cat No.	Product Name
L9000	Apoptosis Compound Library		1796 compounds
	A unique collection of 1796 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;

Libraries

Apoptosis Compound Library

L9000

Compounds: 1796