pregnane

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.

5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone.

Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol(5Beta-Pregnane-3Alpha,20alpha-Diol) has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine.

Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.

Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.

TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.

5α-Pregnane-3α,20α-diol, an active metabolite of progesterone, is synthesized through intermediates 5α-pregnane-20α-ol-3-one and 5α-pregnane-3α-ol-20-one from progesterone. This compound, at a concentration of 10 µM, elevates intracellular calcium levels in washed isolated human platelets.

5α-Pregnane-3β,17α,20α-triol is an endogenous steroid compound. It is a metabolite of Pregnenolone or Progesterone. 5α-Pregnane-3β,17α,20α-triol shows potential for research into placental endocrine function and the mechanisms of steroid hormone metabolism during pregnancy.

Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol. Biol.15610-16(2016) 2.Schiffer, L., Barnard, L., Baranowski, E.S., et al.Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive reviewJ. Steroid Biochem. Mol. Biol.194105439(2019) 3.Disorders of steroidogenesis guide to steroid profiling and biochemical diagnosis1(2019) 4.Shackleton, C.H.L.Role of a disordered steroid metabolome in the elucidation of sterol and steroid biosynthesisLipids47(1)1-12(2012)

Pregnanediol-13C5 Glucuronide (Standard) is a reference standard of Pregnanediol-[13C5] Glucuronide intended for quantitative analysis, quality control, and related biochemical research applications.

Pregnanediol-2,2,3,4,4-D5 (Standard) is a reference standard of Pregnanediol-[2,2,3,4,4-D5] intended for quantitative analysis, quality control, and related biochemical research applications.

Pregnanediol-13C5 (Standard) is a reference standard of Pregnanediol-[13C5] intended for quantitative analysis, quality control, and related biochemical research applications.

Pregnanetriol-[D5] (Standard) is a reference standard of Pregnanetriol-[D5] intended for quantitative analysis, quality control, and related biochemical research applications.

Diethanolamine hydrochloride has a variety of biological activities and is an inhibitor of HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), as well as an agonist of p53 and an antagonist of Estrogen receptor.

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

7α-Hydroxy-4-cholesten-3-one is an intermediate in bile acid synthesis from cholesterol, a PXR agonist, and a biomarker for bile acid loss and diseases related to defective bile acid biosynthesis. It is also the physiological substrate for [CYP8B1].

Deacylmetaplexigenin, a pregnane glycoside, is isolated from *Asclepias incarnata* (swamp milkweed).

CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it also is a selective Constitutive androstane receptor (CAR) agonist.

SJYHJ-026 (compound 37) is a pregnane X receptor (PXR) degrader with a DC50 value of 86.6 nM and a maximum degradation efficacy of 66.4%. This compound demonstrates cytotoxicity in SNU-C4 HiBiT-PXR KI cells, with IC50 values of 97.4 μM (24 h) and 99.5 μM (72 h).

SJPUT-328 is a potent activator of the Pregnane X Receptor (PXR), which plays a crucial role in drug metabolism and drug interactions.

DL5050 is a selective agonist for the human constitutive androstane receptor (hCAR). This compound demonstrates superior affinity and selectivity for hCAR by inducing expression of CYP2B6 (the target of hCAR) at the mRNA and protein levels, rather than CYP3A4 (the target of the human pregnane X receptor, hPXR). As a selective hCAR agonist, DL5050 not only serves as a crucial tool molecule for studying hCAR's biological function but also holds potential as a lead compound for the development of therapeutic applications targeting hCAR.

4,8-Dioxa-3H-perfluorononanoic acid, a type of per- and polyfluoroalkyl substance (PFAS), exhibits affinity for the human pregnane X receptor (hPXR) and demonstrates potential agonistic activity.