pregnane

Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the heart, and has platelet anticoagulant and antihypertensive effects.

Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist

5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, synthesized by androgen-responsive prostate cancer cells under starvation conditions.

5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone.

Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol(5Beta-Pregnane-3Alpha,20alpha-Diol) has two hydroxyl groups, at 3-alpha and 20-alpha. It is detectable in URINE after OVULATION and is found in great quantities in the pregnancy urine.

Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties.

17a-Hydroxypregnenolone, a pregnane steroid, is a prohormone involved in the synthesis of dehydroepiandrosterone (DHEA).

7α-Hydroxy-4-cholesten-3-one is an intermediate in bile acid synthesis from cholesterol, a PXR agonist, and a biomarker for bile acid loss and diseases related to defective bile acid biosynthesis. It is also the physiological substrate for [CYP8B1].

Deacylmetaplexigenin, a pregnane glycoside, is isolated from *Asclepias incarnata* (swamp milkweed).

Sarcostin is a pregnane ester glycoside isolated from the aerial parts of Stapelia variegata.

Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.

Condurango Glycoside E3 (Compound 5), a pregnane glycoside, is isolated from the dried bark of Marsdenia cundurango [1].

Condurango glycoside A0 is a pregnane ester glycoside isolated from *Marsdenia condurango* [1].

Hyperforin, a natural product from Hypericum, is commonly used as an antidepressant and also has neurological, inflammatory, antimicrobial, antitumor and antiangiogenic effects. Hyperforin acts as a monoamine reuptake inhibitor (MRI) in vitro, including serotonin, norepinephrine, dopamine, GABA, and glutamate, with an IC 50 of ≈0.1 μg mL. Hyperforin is also capable of inducing the cytochrome P450 enzymes, CYP3A4 and CYP2C9, through binding to and activation of the pregnane X receptor. Hyperforin is capable of activating TRPC6 channels by binding to a specific motif.

17β-Tenacigenin B, an isomeric pregnane genin, can be isolated from the traditional Chinese anticancer herbal formula known as Xiao Canciping injection (XAPI).

Otophylloside H, a pregnane glycoside isolated from the roots of Cynanchum otophyllum, is utilized in epilepsy research.

Otophylloside J, a pregnane glycoside, can be isolated from the roots of Cynanchum otophyllum. This compound is utilized in the study of epilepsy.

Diethanolamine hydrochloride has a variety of biological activities and is an inhibitor of HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4) and pregnane X receptor (PXR), as well as an agonist of p53 and an antagonist of Estrogen receptor.