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Search Results for " pregnane "

12

Compounds

12

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T83859 5α-Pregnane-3α,20α-diol Allopregnanediol
5α-Pregnane-3α,20α-diol, an active metabolite of progesterone, is synthesized through intermediates 5α-pregnane-20α-ol-3-one and 5α-pregnane-3α-ol-20-one from progesterone. This compound, at a concentration of 10 µM, ele...
T41255 Specific PXR antagonist 70 Others
Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells.
T8944 TTA-A2 Calcium Channel
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels ...
T35665 Pregnanetriol
Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficie...
T4983 Isoetharine mesylate salt Isoetarine mesilate Others , Adrenergic Receptor
Isoetharine mesylate salt (Isoetarine mesilate) is a β-adrenergic receptor agonist. it also is pregnane X receptor (PXR) activator capable of upregulating CYP450 expression.
T6994 SR12813 SR-12813,SR 12813,GW 485801 HMG-CoA Reductase , Autophagy
SR12813 (GW 485801) is a pregnane X receptor (PXR) agonist.
T7618 Pyributicarb TSH-888 P450
Pyributicarb (TSH-888) is a potent activator of both CYP3A4 gene and human pregnane X receptor (hPXR).
T14973 CITCO Apoptosis , Others
CITCO inhibits growth and expansion of brain tumour stem cells (BTSCs) and has an EC50 of 49 nM over pregnane X receptor (PXR), and no activity on other nuclear receptors. CITCO is an imidazothiazole derivative and it al...
T25262 Clometherone Lilly 38000,Lilly38000,Clometeron,Lilly-38000
Clometherone is a synthetic pregnane steroid and derivative of progesterone which is used as an antiestrogen and antiandrogen.
T70387 CCCTP
CCCTP is a potent inhibitor of the 11β-HSD-1 enzyme with reduced pregnane-X receptor (PXR) transactivation activity.
T37351 Desmethyl Bosentan
Desmethyl bosentan is an active metabolite of the endothelin receptor antagonist bosentan .1Desmethyl bosentan (25 μM) activates the pregnane X receptor (PXR) in CV-1 monkey kidney cells expressing the human receptor in ...
T83765 Dendrogenin A ​DDA
Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest...
Cat No. Product Name Synonyms Targets
T5556 5a-Pregnane-3,20-dione Endogenous Metabolite
5a-Pregnane-3,20-dione is a biologically active 5-alpha-reduced metabolite of plasma progesterone
T13518 5α-Pregnane-3β,6α-diol-20-one Others
5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, capable of being synthesized by androgen-responsive prostate cancer cells under conditions of starvation.
T1688 Pregnanediol 5Beta-Pregnane-3Alpha,20alpha-Diol,Pregnandiol Estrogen/progestogen Receptor , Endogenous Metabolite
Pregnanediol (5Beta-Pregnane-3Alpha,20alpha-Diol) is an inactive metabolite of PROGESTERONE by reduction at C5, C3, and C20 position. Pregnanediol(5Beta-Pregnane-3Alpha,20alpha-Diol) has two hydroxyl groups, at 3-alpha a...
T7974 Lynestrenol Progesterone Receptor
Lynestrenol is a synthetic progestational hormone, is the progesterone receptor agonist
T7024 Qingyangshengenin Qingyangshengenin A,Cynanchagenin Others
Qingyangshengenin (Cynanchagenin) is a steroid used in the preparation of antiepileptic agents.
T2939 Forskolin Coleonol,Colforsin FXR , Adenylyl cyclase , AChR , Autophagy
Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...
T10048 17a-Hydroxypregnenolone Endogenous Metabolite
17a-Hydroxypregnenolone is a pregnane steroid. It is a prohormone in the formation of dehydroepiandrosterone (DHEA).
T7646 Alloepipregnanolone Endogenous Metabolite
Alloepipregnanolone is a pregnane with anesthetic, hypnotic, and sedative properties.
T13638 Deacylmetaplexigenin Others
Deacylmetaplexigenin is a pregnane glycoside isolated from Asclepias incarnate.
T34529 Sarcostin
Sarcostin is a pregnane ester glycoside isolated from the aerial parts of Stapelia variegata.
T82689 Condurango glycoside A0
Condurango glycoside A0 is a pregnane ester glycoside isolated from Marsdenia condurango [1].
T82685 Condurango glycoside E3
Condurango Glycoside E3 (Compound 5), a pregnane glycoside, is isolated from the dried bark of Marsdenia cundurango [1].

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02987 Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TMPY-02706 Vitamin D Receptor/VDR Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TargetMol