placenta

Prochloraz (Prelude) is a broad-spectrum contact imidazole fungicide. Prochloraz inhibits human placental microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an estrogen receptor (IC50s = 25 μM) and androgen receptor (IC50 = 4 μM) antagonist, and activates aryl hydrocarbon receptors (EC50 = 1 μM).

Type V collagen, highly purified from human placenta (Human Placenta Type V collagen, immunization grade), is a form of collagen protein that induces an immune response in animals, leading to the production of specific antibodies against this collagen. It also serves as a substrate for matrix metalloproteinases (MMP).

Human Type III collagen, derived from human placenta (immunization grade), is a highly purified compound capable of eliciting an immune response in animals to produce specific antibodies against this collagen protein. Additionally, this collagen serves as a substrate for the hydrolysis by matrix metalloproteinases (MMPs).

Human Type I collagen, derived from highly purified human placenta and classified as immunization grade, stimulates the animal immune system to produce specific antibodies against this collagen. Additionally, collagen serves as a hydrolytic substrate for MMP (Matrix Metalloproteinases).

Alkaline Phosphatase (ALP), Human Placental (ALP, PLAP, Alk Phos), serves as a biological material or organic compound useful for life science research.

Minamestane is a novel irreversible aromatase inhibitor.Minamestane induces time-dependent inhibition of human placental aromatase with a half-life of 4 minutes and a K of 59 nM.Minamestane has antitumor activity.

Oxybenzone is a UV filter commonly used in tanning and skin protection agents. It is a derivative of benzophenone and is used as an endocrine disrupting chemical that penetrates the placental and blood-brain barriers. It impairs autophagy, alters epigenetic status and disrupts vitamin X-like receptor signaling in apoptotic neuronal cells.

Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy.

Progesterone is a steroid hormone that regulates the menstrual cycle and is essential for pregnancy. It is also commonly used to induce melasma models.

Estrone (Aquacrine) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Estriol (Oestriol) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed

eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) (387-394) [Multiple species](TFA) is Elongation factor 1 subunit.eukaryotic translation elongation factor 1 alpha 1 (EEF1A1) encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in the brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in the brain, heart, and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes1.

IgG has four forms, provides the majority of antibody-based immunity against invading pathogens. The only antibody capable of crossing the placenta to give passive immunity to the fetus. Eliminates pathogens in the early stages of B cell-mediated (humoral

YM 511 is a highly specific non-steroidal aromatase inhibitor. YM 511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM 511 slightly inhibits production of other steroid hormones. YM 511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones.

β-Endorphin (β-EP) is an endogenous opioid neuropeptide with diverse biological activities. It is produced via piomelanocortin cleavage in the pituitary gland, hypothalamus, and in lymphocytes, then migrates to its sites of action which include plasma, gut, skin, placenta, cerebrospinal fluid, and cardiac tissues. β-EP induces concentration-dependent decreases in electrically stimulated contraction of the mouse vas deferens that can be reversed by the μ-opioid antagonist CTP and δ-opioid antagonist ICI 174,864. In vivo, β-EP (5 μg, i.c.v.) slows gastrointestinal transit in mice. β-EP (0.5 or 5 μg, i.c.v.) stimulates food intake in rats for 4 to 6 hours, however, this effect is not prolonged with continuous infusion. It antagonizes the appetite-suppressive effects of α-melanocyte-stimulating hormone (α-MSH) for the first three days post administration. β-EP also reduces paralytic demyelination induced by the murine coronavirus MHV-JHM in immunocompetent, but not irradiated or immune-incompetent, mice and rats.

MAGE-3 (271-279) is a peptide consisting of 271-279 amino acid residues derived from melanoma antigens encoded by the MAGE-3 gene. It is specifically recognized by cytolytic T lymphocytes (CTLs) and binds to the human leukocyte antigen (HLA)-A2 molecule. MAGE-3 is highly expressed in various human tumor types, such as malignant melanoma, but not in normal tissues, except for the testis and placenta.

Steroid Sulfatase-IN-6 (Compound 10c) serves as an irreversible steroid sulfatase (STS) inhibitor, exhibiting a K i value of 0.4 nM against human placenta STS, and is applicable in tumor disease research [1].

Anti-ALP Antibody is a humanized monoclonal antibody targeting Alkaline Phosphatase (ALP). Alkaline Phosphatase is a group of membrane-bound glycoprotein enzymes widely distributed in various tissues (e.g., liver, bone, kidney, placenta), responsible for catalyzing the hydrolysis of phosphate monoesters. ALP is classified into Tissue-Nonspecific Alkaline Phosphatase (TNSALP/ALPL) and tissue-specific isoenzymes (e.g., Placental Alkaline Phosphatase, PLAP/ALPP). Anti-ALP Antibody specifically binds to ALP, serving as a key tool for detecting bone mineralization and liver function markers. It is also extensively used in biotechnological applications (e.g., as part of enzyme-conjugated secondary antibodies or substrate detection systems) and basic research to quantify ALP activity levels on cell surfaces or in serum.

RO5323441 is a humanized monoclonal antibody specifically targeting the human placenta growth factor (PlGF). The compound binds to PlGF, blocking its interaction with the receptor VEGFR-1 (Flt-1) and thereby inhibiting downstream signaling. In experimental studies, RO5323441 is utilized to inhibit angiogenic pathways, block PlGF-induced receptor phosphorylation, and suppress tumor growth.

16α-Hydroxy-17β-estradiol-2,4-D2 is a deuterated compound of 16α-Hydroxy-17β-estradiol (TMSM-1124). Estriol has a CAS number of 50-27-1. Estriol is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estrone-D4 is a deuterated compound of Estrone. Estrone (T1009) has a CAS number of 53-16-7. Estrone (T1009) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.

Estriol-D3 is a deuterated compound of Estriol. Estriol (T1571) has a CAS number of 50-27-1. Estriol (T1571) is a hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol (T1571) is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA.

Estrone-D2 is a deuterated compound of Estrone. Estrone (T1009) has a CAS number of 53-16-7. Estrone (T1009) is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone, a major mammalian estrogen. It is converted from ANDROSTENEDIONE directly, or from TESTOSTERONE via ESTRADIOL. In humans, it is produced primarily by the cyclic ovaries, PLACENTA, and the ADIPOSE TISSUE of men and postmenopausal women.