ncx

cyclooxygenase (COX)-inhibiting nitric oxide (NO) donor

NCX 1000, a liver-specific NO donor compound, is derived from ursodeoxycholic acid (UDCA).

COX-2 expression inhibitor

NCX-274 is a ROCK inhibitor and NO-donating anti-glaucoma agent

NCX-278 is a ROCK inhibitor and NO-donating anti-glaucoma agent.

NCX-6560 is a novel NO-releasing derivative of atorvastatin, with those of atorvastatin. NCX-6560 inhibits cholesterol biosynthesis in rat smooth muscle cells with an IC50 of 1.9 μM.

NCX1022 is a NO-releasing derivative of Hydrocortisone. It is the most widely used anti-inflammatory drug for the treatment of skin inflammation.

NCX899 shows inhibitory activity against angiotensin-converting enzyme (ACE) activity.

NCX1-IN-1 (Compound 6) is an inhibitor of the Na+ Ca2+ exchanger (NCX).

ORM-10103 is a novel potent and selective inhibitor of the Na+ Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM at -80 and 20 mV, respectively, and reduced early and delayed postdepolarization in canine hearts.

NO-prednisolone (NCX-1015) is a compound that effectively stimulates the production of IL-10 in vivo. It is a Prednisolone derivative that releases nitric oxide (NO).

SAR296968 is a novel selective NCX inhibitor, improving cardiac function and restoring sympathovagal balance in heart failure.

Bepridil hydrochloride (CERM 1978) is a calcium channel blocker that also inhibits Na+ Ca2+ exchange (NCX), sodium channels, and cardiac sarcolemmal KATP channels.

SEA0400 is a selective inhibitor of the Na+ Ca2+ exchanger.

Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin that inhibits cyclooxygenase. It induces cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells by down-regulating EGFR PI3K STAT3 signaling and modulating Bcl-2 family proteins. Additionally, Nitroaspirin possesses antithrombotic and antiplatelet properties and acts as a direct and irreversible inhibitor of COX-1.

SN 6 (SN6) is a selective Na+ Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)

PU-H71 hydrate is a potent inhibitor of heat shock protein 90 (Hsp90).

ORM-10962 is a potent and highly selective inhibitor of the sodium-calcium exchanger (NCX), with IC50 values of 67 nM for reverse mode inhibition and 55 nM for forward mode inhibition.

Nitroparacetamol is nitric oxide (NO) donor and may be used to treat pain.

TPI-1020 is a novel anti-inflammatory corticosteroid and nitric oxide (NO) donor derived from budesonide. It exhibits a concentration-dependent bronchodilatory effect mediated by released NO through a cGMP-dependent pathway. Studies suggest that TPI-1020 combines corticosteroid activity with NO release, potentially benefiting the treatment of acute bronchoconstriction events in asthma and allowing for a reduced dose of inhaled beta(2)-adrenoceptor agonists.

inhibitor of the reverse mode of Na+ Ca2+ exchange (NCX)

Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).

AM0216 is a novel highly potent inhibitor of NF-κB inducing Kinase (NIK).

Latanoprostene bunod (LBN) is nitric oxide (NO)-donating prostaglandin F2a analog and is a topical ophthalmic therapeutic. It is used for the reduction of intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension (OHT).