mushroom

Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion

Orellanine is a nephrotoxic compound extracted from the mushroom Cortinarius orellanus. Orellanine strongly inhibits the synthesis of macromolecules (Proteins, RNA and DNA) in Madin-Darby canine kidney cells and in rat liver mitochondria.

antcin A is a steroid-like phytochemical isolated from the fruiting bodies of a precious edible mushroom Antrodia cinnamomea with strong anti-inflammatory and anti-tumor effects.

4-Isopropylbenzoic acid (Cumic acid) is an aromatic monoterpenoid isolated from the stem bark of Bridelia retusa. 4-Isopropylbenzoic acid shows antifungal activities. 4-Isopropylbenzoic acid is also a reversible and uncompetitive mushroom tyrosinase inhibitor.

p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.

Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 μM for mushroom tyrosinase.

Benzylacetone (4-Phenyl-2-butanone) is an aromatic compound extracted from incense wood. Benzylacetone has appetite-enhancing and exercise-reducing properties. Benzylacetone has a strong and reversible anti-mushroom tyrosinase effect, with IC50 values of 2.8 mM and 0.6 mM for monophenolase and biphenolase effects, respectively.

Tetrahydrofolic acid trihydrochloride (L-5,6,7,8-Tetrahydrofolic acid trihydrochloride) is a biologically active vitamin B9 derivative, a receptor for free formaldehyde, and an effective suicide substrate for mushroom tyrosinase, inhibiting indole ethylamine methylation by methyl-tetrahydrofolate.

γ-Amanitin, an ADC (antibody-drug conjugate) cytotoxin isolated from mushrooms, inhibits RNA polymerase II, disrupting mRNA synthesis. It exhibits effects akin to those of α-Amanitin and β-Amanitin.

ε-Amanitin is a cyclic peptide obtained from various mushroom species. It exhibits a strong affinity for RNA polymerase II and effectively inhibits its activity.

Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.

Benzoyloxypaeoniflorin (Benzoyloxypeoniflorin) is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coagulation.

Ibotenic acid hydrate ((RS)-Ibotenic acid hydrate) is an excitatory amino acid receptor agonist that primarily exerts its effects by activating glutamate receptors, such as NMDA receptors. Ibotenic acid hydrate can be extracted from the fly agaric mushroom (Amanita muscaria).

Dihydroaltenuene B acts as an effective mushroom tyrosinase inhibitor, exhibiting an inhibition concentration (IC50) of 38.33 µM. It demonstrates hydrogen bonding interactions with the His244, Met280, and Gly281 residues of tyrosinase through its 3-OH and 4'-OH groups.

Phaeosphaone D, a thiodiketopiperazine alkaloid isolated from the endophytic fungus Phaeosphaeria fuckelii, exhibits inhibitory activity against mushroom tyrosinase, with an IC50 value of 33.2 μM [1].

Chetoseminudin B exhibits inhibitory activity against mushroom tyrosinase, with an IC 50 value of 31.7 μM [1].

Isoguaiacin, a natural product [1], exhibits (hass) the potential to be (to exist as) an (a) effective pharmacological agent due to its (its) ability to inhibit (the inhibition of) mushroom tyrosinase. This (The) inhibition is (taking place) in a manner that demonstrates greater (a higher) selectivity towards mushroom tyrosinase compared to human tyrosinase, suggesting a reduced (a lower) risk of off-target effects in humans. Additionally, isoguaiacin shows (displays) promising (promising) activity against (in combating) certain cancer cell lines, further affirming its potential as (an) anticancer agent.

Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggregation. Broussoflavonol F shows inhibitory activities on mushroom tyrosinase. Broussoflavonol F

p-Tolualdehyde (Standard) is the standard substance of p-Tolualdehyde, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. p-Tolualdehyde is a RIFM flavor that shows inhibition of mushroom tyrosinase.

Melanoxazal is an inhibitor of melanin biosynthesis, effectively suppressing melanin formation in silkworm larva hemolymph with an IC50 of 30.1 μg/mL, and it also exhibits strong inhibitory effects on mushroom tyrosinase (IC50 of 4.2 μg/mL), while lacking antibacterial activity.

Theleganbanin B is a p-terphenyl derivative discovered in the mushroom (Thelephora ganbajun). It inhibits the production of TNF-α, IL-6, and IL-1β in BV-2 microglial cells induced by LPS. Theleganbanin B also suppresses the phosphorylation of JAK2/STAT3 and holds potential for neurodegenerative disease research.

Isoanhydroicaritin is a naturally occurring flavonoid that inhibits physiological melanin synthesis and recovery and inhibits mushroom tyrosinase.

Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.