mkk

MKK7-COV-9 is a selective and potent covalent inhibitor of MKK7 with inhibitory effects on MKK7-induced protein-protein interactions.MKK7-COV-9 interrupts the activation of primary B-cells in response to LPS.MKK7-COV-9 shows low cytotoxicity at high concentrations.

SGC-CAMKK2-1 is a selective inhibitor of calcium calmodulin-dependent protein kinase kinase 2 (CAMKK2) with an IC50 of 30 nM. It effectively inhibits AMPK phosphorylation in C4-2 cells, exhibiting an IC50 value of 1.6 µM.

TAT-MKK3b is a peptide inhibitor of p38 and can inhibit the phosphorylation of p38. It has renal targeting capabilities, is effective in scavenging reactive oxygen species (ROS), and can alleviate ferroptosis (ferroptosis). TAT-MKK3b may improve acute kidney injury and its progression to chronic kidney disease.