mch-1

MCH-1 antagonist 1 also inhibits CYP3A4 (IC50: 10μM).MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist (Ki: 2.6 nM).

SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)

MCHR1 antagonist 2 is an inhibitor of melanin-concentrating hormone receptor 1 (MCH1-R, IC50 = 65 nM) and also inhibits hERG.

GW-803430 (GW-3430) is an orally active and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist used in the study of obesity.

MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.

MCHR1 antagonist 1 is a selective antagonist of the melanin-concentrating hormone-1 (MCH1) receptor with a Kb of 1 nM and a Ki of 4 nM at the human MCH1 receptor.

TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.

ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.

SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.

[Ala17]-MCH acetate is a selective ligand for MCHR1 with a Ki of 0.16 nM and Kd of 0.37 nM(Eu3+ chelate-labeled). [Ala17]-MCH acetate shows selectivity over MCHR2 with Ki of 34 nM.

HMCH-1R Antagonist 1 (Compound 30) serves as an effective and selective antagonist for the human melanin-concentrating hormone receptor 1 (hMCHR1), exhibiting a K_B value of 3.6 nM. It possesses the ability to bind to hMCHR1 and hMCHR2, with IC_50 values of 65 nM and 49 nM, respectively. This compound is applicable in metabolic research [1].

AZD1979 is a highly potent MCHR1 (Melanin-concentrating hormone receptor 1) antagonist with an IC50 of 12 nM, exhibiting improved central nervous system (CNS) exposure and enhanced insulin sensitivity in steady-state model assessments, making it suitable for the treatment of obesity.

BMS-819881, a melanin-concentrating hormone receptor 1 (MCHR1) antagonist, binds rat MCHR1 with a Ki of 7 nM, and is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

ATC0175 is a potent, selective, and orally active antagonist of the melanin-concentrating hormone 1 receptor (MCH1R), with IC50 values of 13.5 nM for MCH1R and greater than 10,000 nM for MCH2R, demonstrating antidepressant and anxiolytic effects in animal models and providing strong experimental relevance for depression and anxiety disorder research.

3-Piperidinyl(1-pyrrolidinyl)methanone hydrochloride can be used in the synthesis of piperidin-4-yl-urea derivatives which are MCH-R1 antagonists.

Melanin Concentrating Hormone, salmon acetate (MCH (salmon)) is a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.

Oligomycin A (MCH 32) is an inhibitor of ATP synthase, inhibits oxidative phosphorylation and all the ATP-dependent processes occurring on the coupling membrane of mitochondria.

[Ala17]-MCH TFA, a selective ligand for MCHR 1 (K i =0.16 nM) over MCHR 2 (K i =34 nM), is an analogue of MCH. When labeled with a [Eu 3+ chelate], [Ala17]-MCH exhibits high affinity for MCHR 1 (K d =0.37 nM) and negligible binding affinity for MCHR 2.

MCH (human, mouse, rat) TFA is a potent peptide agonist for MCH receptors, exhibiting binding IC50 values of 0.3 nM for MCH1R and 1.5 nM for MCH2R. It is particularly effective against MCH-2R in a CHO cell line, with functional activation EC50 values of 3.9 nM for MCH-1R and 0.1 nM for MCH-2R, as evidenced by intracellular calcium mobilization measured with FLIPR [1].

Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA), is a 19-amino-acid neuropeptide discovered in the pituitary gland of teleost fish; it regulates food intake, energy balance, sleep states, and cardiovascular functions, and acts as a ligand for the orphan G protein-coupled receptors SLC-1/GPR24 and MCHR2.

(Phe13,Tyr19)-MCH (human, mouse, rat) is a potent ligand and agonist for SLC-1 and S643b receptors [1].

ALB-127158(a) is a potent and selective melanin-concentrating hormone 1 (MCH 1) receptor antagonist that may potentially treat inflammatory bowel disease (IBD).