lipolysis — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T31976	Glymidine sodium		Others
	Glymidine sodium is a sulfonamide hypoglycemic agent which stimulates insulin secretion.		Others
T9753	LEI110		Phospholipase
	LEI110 is a potent Phospholipase A2, group XVI (PLA2G16) inhibitor with an Ki value of 20 nM. LEI110 is a selective pan-inhibitor of the HRASLS family of thiol hydrolases (i.e., PLA2G16, HRASLS2, RARRES3 and iNAT).		Phospholipase
T1162	Acipimox	Olbemox,K-9321	Others
	Acipimox (K-9321) is a niacin derivative and nicotinic acid analog with activity as a hypolipidemic agent. Acipimox has special application for the treatment of hyperlipidemia in non-insulin-dependent diabetic patients.		Others
T77621	Z16078526		p38 MAPK , Mitochondrial Metabolism
	Z16078526 enhances thermogenesis in mice by inducing endogenous Ucp1 expression, promoting p38 MAPK phosphorylation, and stimulating lipolysis in primary mouse brown adipocytes. Additionally, it activates thermogenic gen...		p38 MAPK , Mitochondrial Metabolism
T4S0227	Sinensetin	Pedalitin permethyl ether	TNF , PGE Synthase
	Sinensetin (Pedalitin permethyl ether) is a methylated flavone found in certain citrus fruits. pocess potent antiangiogenesis and anti-inflammatory, sinensetin enhances adipogenesis and lipolysis.		TNF , PGE Synthase
T1875	Atglistatin		Lipase
	Atglistatin is a highly effective, specific and competitive ATGL inhibitor with an IC50 of ~0.7 μM for inhibition of lipolysis in vitro, and no toxicity when the concentration up to 50 μM.		Lipase
T8209	Saikosaponin b3		Others
	Saikosaponin b3 is isolated from the roots of Bupleurum falcatum L.. Saikosaponin b3 inhibits ACTH-induced lipolysis in the fat cells and exhibits analgesic effects.		Others
T19924	Rhododendrol	Betuligenol,Frambinol	Others
	Rhododendrol (Frambinol) is a melanin synthesis and acts by preventing high-fat diet-induced elevation in body weight and increasing lipolysis in white adipocytes in male mice. Rhododendrol can be used as the lightening/...		Others
T15432	GSK256073		GPR , Others
	GSK256073 is an orally active GPR109A agonist. GSK256073 also is a long-lasting and non-flushing HCA2 (hydroxy-carboxylic acid receptor 2) full agonist (pEC50: 7.5). GSK256073 acutely improves glucose homeostasis via inh...		GPR , Others
T10830	CL 316243		Adrenergic Receptor
	CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL3162...		Adrenergic Receptor
T62656	GPR81 agonist 1		GPR
	GPR81 agonist 1 is a potent and selective GPR81 agonist with high affinity for human and mouse GPR81.GPR81 agonist 1 inhibits lipolysis of differentiated 3T3-L1 adipocytes, improves insulin sensitivity and glycaemic cont...		GPR
T73499	NG-497	NG497	Lipase
	NG-497 is a selective, small molecule inhibitor of human adipose triglyceride lipase (ATGL) that targets the enzymatically active patatin-like structural domain of human ATGL.NG-497 binds ATGL in a hydrophobic lumen adja...		Lipase
TP1219	Atrial Natriuretic Peptide (ANP) (1-28), human, porcine Acetate	ANP (1-28), human, porcineANP(1-28)

TP2267	Lys-γ3-MSH(human)	Lys-γ3-MSH	Others
	Pro-opiomelanocortin (POMC) derived peptide that stimulates lipolysis		Others
T19338	Gelucire 44/14	Gelucire 14/44	Others
	Gelucire 44/14 (Gelucire 14/44) acts as a nonionic surface-active excipient and improves fat absorption in rats with impaired lipolysis.		Others
T26935	C108297	C-108297,C 108297
	C108297 is a glucocorticoid receptor modulator. C108297 prevents both diet-induced obesity and inflammation. C108297 decreased food and fructose intake and increased lipolysis in white adipose tissue (WAT) and free fatty...
T61464	TRβ agonist 2
	TRβ agonist 2 (Compound 1) is a highly potent agonist of TRβ. Moreover, it effectively reduces lipid accumulation in HepG2 cells and promotes lipolysis, offering comparable effects. With its promising attributes, TRβ ago...
T82732	Cholecystokinin (1-21)	CCK-1-21
	Cholecystokinin (1-21) (CCK-1-21), a fragment of cholecystokinin (CCK), induces lipolysis in human adipose tissue [1].
T75849	Lys-γ3-MSH(human) TFA
	Lys-γ3-MSH(human) TFA, a melanocortin peptide originating from the C-terminal fragment of pro-opiomelanocortin (POMC), enhances the steroidogenic response of rat adrenal glands to adrenocorticotrophin (ACTH). It is a pot...
T81013	Tert-OMe-byakangelicin
	Tert-OMe-byakangelicin is a coumarin known to potentiate adrenaline-induced lipolysis and impede insulin-mediated triglyceride synthesis from glucose in adipocytes [1].