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  • LIM Kinase
    (9)
  • PKA
    (2)
  • PROTACs
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  • ROCK
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Results for "

limk2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    18
    TargetMol | Inhibitors_Agonists
  • PROTAC Products
    2
    TargetMol | PROTAC
  • Natural Products
    1
    TargetMol | Natural_Products
T56-LIMKi
T5601640
T3960924473-59-6
T56-LIMKi (T5601640) is a selective inhibitor of LIMK2.
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BMS-5
LIMKi 3, BMS5
T45981338247-35-0
BMS-5 (LIMKi 3) is a highly potent LIMK inhibitor, exhibiting IC50 values of 7 nM for LIMK1 and 8 nM for LIMK2.
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TargetMol | Citations Cited
LX-7101 hydrochloride
LX7101 hydrochloride, LX 7101 hydrochloride
T329851374644-80-0In house
LX-7101 hydrochloride is a potent LIMK and ROCK2 inhibitor with antihypertensive activity, inhibits LIMK1 2, ROCK, PKA, and can be used to study glaucoma.
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LX7101
T157981192189-69-7In house
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
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6-8 weeks
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TH-257
TH 257
T71282244678-29-1
TH-257 is a Potent and selective allosteric LIMK 1 2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
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TargetMol | Inhibitor Sale
TH-263
T19578313520-94-4
TH-263 is inactive toward both LIMK1 and LIMK2 and thus can be used as negative control for TH-257, and is a diaryl sulfonamide derivative.
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TargetMol | Inhibitor Sale
BMS-3
T46001338247-30-5
BMS-3 is a potent LIMK inhibitor with IC50 values of 5 nM and 6 nM for LIMK1 and LIMK2, respectively.
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TargetMol | Inhibitor Sale
limk-in-22j
LIMK inhibitor-22j, LIMK inhibitor 22j, LIMK IN 22j
T244101116571-01-7
LIMK-IN-22j (LIMK inhibitor 22j) is an effective and selective inhibitor of LIMK.
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TargetMol | Inhibitor Sale
AWL-II-38.3
T385111135205-94-5
AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.
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TH251
T703641622059-04-4
TH251 is a highly selective antagonist of LIMK1 and LIMK2 (LIMK1 2).
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6-8 weeks
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FMF-06-098-1
T823852769753-07-1
FMF-06-098-1 is a multitargeted depressant that promotes the degradation of various kinases including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D, EPHA1, PAK, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, SGK2, STK35, TNK2, UHMK1, ULK1, and WEE1 [1].
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th470
T735452834739-51-2
TH470, a potent and highly selective inhibitor of LIM kinase 1 2 (LIMK1 2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2, making it applicable in orphan disease research.
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6-8 weeks
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DB0614
T746442769753-47-9
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK, LCK, LIMK2, MAP3KH, MAPK8, MAPK9, NEK9, PLK4, PTK2B, SIK2, STK17A, STK17B, ULK1, ULK3, and WEE1. This compound has potential applications in research on diseases or disorders caused by aberrant kinase activity [1].
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DD-03-156
T74102
DD-03-156 is a potent and selective degrader of CDK17 and LIMK2 . The selectivity and potency of DD-03-156 is exquisite and makes an advanced starting point for the development of a chemical probe for the degradation of CDK17 [1] .
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CRT-0105950
CRT0105950, CRT 0105950
T239171661845-86-8
CRT-0105950 is a potent LIMK inhibitor with high affinity for both LIMK1 and LIMK2.CRT-0105950 inhibits filamentous cutin phosphorylation and promotes α-microtubulin acetylation in cells.CRT-0105950 can be used in the study of renal carcinoma.
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6-8 weeks
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Damnacanthal
Damnacantal
TN1549477-84-9
Damnacanthal is a natural anthraquinone compound with potential anticancer, anti-inflammatory, antioxidant, anti-malarial, and antiviral effects.Damnacanthal inhibits a variety of protein kinases such as LIMK1 (IC50=0.8 μM), LIMK2 (IC50=1.5 μM), and Lck (IC50=17 nM), and inhibits the growth of human hepatocellular carcinoma (SKHep-1) and human breast cancer (MCF-7) cells.
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lx7101 hydrochloride
T853042319882-48-7
LX7101 is a potent inhibitor of both LIM kinase (LIMK) 1 and 2, and Rho-associated kinase 1 (ROCK1) and ROCK2, with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, demonstrated by its lack of cross-reactivity in a panel of binding assays involving 78 receptors, transporters, and an additional 430 kinases, at a concentration of 10 μM. The topical administration of LX7101 (3 μl of a 1 mg ml solution) to the eye has been shown to reduce intraocular pressure in a dexamethasone-induced mouse model of glaucoma.
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8-10 weeks
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limk1 inhibitor bms-4
T72399905298-84-2
LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1 2, specifically inhibiting the phosphorylation of its substrate cofilin, while remaining noncytotoxic on A549 cells.
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6-8 weeks
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