hsf1

HSF1A is a cell-permeable activator of HSF1 that protects mammalian cells against stress-induced apoptosis (HSF1).

Rocaglamide (Roc-A), isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB activation in T-cells.

CCT251236 is a cell-based phenotypic high-throughput screening (HTS) chemical probe developed to screen for inhibitors of the HSF1 stress pathway.CCT251236 exhibits antimyeloma activity and inhibits HSF1.

KRIBB11 is an inhibitor of Heat Shock Factor (HSF) [inhibitor].

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.

DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.

NPX800 is an inhibitor of heat shock factor 1 (HSF1) and can be used in studies about the treatment of cancer.

Triptolide (PG490) belongs to the tricyclic diterpenoid group of natural products and is an inhibitor of NF-κB activation. Triptolide exhibits immunosuppressive, anti-rheumatic, anti-inflammatory, anti-proliferative and anti-tumor activities.

Azadiradione (AZD) (AZD) from the methanolic extract of seeds of Azadirachta indica

AEG 3482 is a potent antiapoptotic compound. AEG 3482 inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG 3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

CCT245232 is a potent inhibitor of heat-stimulated factor 1 (HSF1) with potential applications in studies of proliferative diseases, such as cancer.

Tonantzitlolone is a natural agonist of tprc1/4/5 channels, also acting as a dual pkcα and pkcθ activator, inducing an insulin resistant phenotype by inhibiting irs1 and the pi3k/akt pathway, activating the heat shock factor 1 (hsf1) transcription factor driving glucose dependency

NZ28, also known as NSC134754, is potent HSF1 inhibitor, which induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis.

Mycothiazole is an inhibitor of mitochondrial electron transport chain (ETC) complex I. It exhibits cytotoxicity in cancer cells Huh7 (IC50 of 55.8 μM), U87, and MCF7. In Huh7 cells, Mycothiazole induces apoptosis (apoptosis). Additionally, Mycothiazole extends the lifespan of C. elegans by modulating transcription factors ATFS-1 and HSF1, which are associated with the unfolded protein response (UPR) and heat shock response (HSR).

Withanolide D (Compound 2) is a steroidal lactone found in Withania somnifera (L.) Dunal. It exhibits cytotoxicity against various cancer cell lines, with IC50 values of 324 nM for CHP-100 cells and 710 nM for 293T cells. Additionally, Withanolide D activates heat shock factor 1 (HSF1)-dependent stress response and can be used in lymphoma cancer research.

Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.

Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).