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  • HIF/HIF Prolyl-Hydroxylase
    (10)
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hif-phd2

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    13
    TargetMol | Inhibitors_Agonists
  • Recombinant Protein
    2
    TargetMol | Recombinant_Protein
IOX2
JICL38, IOX 2
T1823931398-72-0
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2 ELGN-1 and no inhibition at FIH (20uM).
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KRH102140
KRH 102140
T68511864769-01-7
KRH102140 is a PHD2 activator that reduces angiogenesis by inhibiting HIF-1alpha, used in cardiovascular disease research.
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6-8 weeks
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Molidustat
BAY 85-3934
T26521154028-82-6
Molidustat (BAY 85-3934)(BAY-85-3934), an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase (PH), stimulates erythropoietin (EPO) production and the formation of red blood cells.
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Adaptaquin
T22022385786-48-1
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
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TargetMol | Inhibitor Sale
FG-2216
YM-311, FG2216, FG 2216
T2445223387-75-5
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.
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Izilendustat
T643361303512-02-8
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
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JNJ-42041935
HIF-PHD Inhibitor II
T31801193383-09-3
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
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HIF-PHD-IN-1
T390401567657-46-8
HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therapeutic agent for renal anemia is highly promising.
    7-10 days
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    MK-8617
    MK8617
    T41061187990-87-9
    MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1 2 3 (IC50: 1.0 1.0 14 nM).
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    TP0463518
    T53921558021-37-6
    TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
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    HIF-PHD-IN-2
    T614582711720-45-3
    HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor with IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].
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    6-8 weeks
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    IOX4
    T78801154097-71-8
    IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
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    PHD2-IN-1
    T792412768219-28-7
    PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].
    • Inquiry Price
    8-10 weeks
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