Search Result

Search Results for " hemorrhage "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T21902	ML351		Lipoxygenase
	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).		Lipoxygenase
T4552	Fursultiamine	Diteftin,Judolor,Alinamin F	Others
	Fursultiamine (Alinamin F) is a disulfide derivative of thiamine, or an allithiamine. It has potential uses in the treatment of vitamin B1 deficiency.		Others
T7601L	Carbetocin acetate	Carbetocin acetate(37025-55-1 free base)	Oxytocin Receptor
	Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T15247	ESI-05	NSC 116966	cAMP
	ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.		cAMP
T22285	Carboprost	15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α	Prostaglandin Receptor
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone.		Prostaglandin Receptor
T11571	HLY78	4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine	Wnt/beta-catenin
	HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling.		Wnt/beta-catenin
T7601	Carbetocin		Oxytocin Receptor
	Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.		Oxytocin Receptor
T70470	CM-352		MMP
	CM-352 is a metalloproteinase inhibitor that reduces brain damage and improves functional recovery in rat models of cerebral hemorrhage.		MMP
T8857	LJP-1586 HCl	LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586	Others
	LJP-1586 HCl, a highly selective inhibitor of vascular adhesion protein-1 (VAP-1), exhibits antiinflammation effect by reducing adhesion molecule expression and immune cell infiltration after intracerebral hemorrhage (IC...		Others
T11662L	INT-777	S-EMCA	GPCR19
	INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM. INT-777 (S-EMCA) inhibits NLRP5-ASC inflammasome-mediated neuroinflammation via the TGR3/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats...		GPCR19
T50100	3-hydroxy-3-phenylpentanamide		Others
	3-hydroxy-3-phenylpentanamide is a chiral compound belonging to the class of beta-hydroxyamides. In neurology, it has been shown to have neuroprotective effects against ischemic brain injury and cerebral hemorrhage. In p...		Others
T3560	Desmethylanethol trithione	ADT-OH	VEGFR , Akt
	Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly...		VEGFR , Akt
T61677	PiCRAC-1
	piCRAC-1 is a powerful inhibitor of the photoinducible Ca2+ release-activated Ca2+ (CRAC) channel. It effectively alleviates thrombocytopenia and hemorrhage [1].
T11152	Edaravone-d5	MCI-186 D5	Others
	Edaravone, a novel and potent free radical scavenger, effectively prevents MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. Its deuterium-labeled variant, Edaravone D5, retains the origin...		Others
T38058	Cimetidine sulfoxide
	Cimetidine sulfoxide (Cimetidine sulphoxide) is a metabolite of Cimetidine, functioning as a histamine H2-receptor antagonist with potential applications in treating peptic ulcer disease and upper gastrointestinal hemorr...
TP1953	PG-931	PG 931
	Potent and selective melanocortin 4 (MC4) receptor agonist (IC50 values are 0.58 and 55 nM for human MC4 and MC3 receptors respectively). Produces a rapid and dose dependent restoration of cardiovascular and respiratory ...
T70186	Methazolamide-d6
	Methazolamide-d6 is intended for use as an internal standard for the quantification of methazolamide by GC- or LC-MS. Methazolamide is a carbonic anhydrase inhibitor. It reduces intraocular pressure and cerebrospinal flu...
T73989	Tirilazad
	Tirilazad, a nonglucocorticoid 21-aminosteroid, serves to inhibit lipid peroxidation. It mitigates the effects of trauma-induced brain or spinal cord injury, as well as damage resulting from stroke, ischemia, and reperfu...
T83851	Tat-QFNP12 TFA
	Tat-QFNP12 is a peptide that combines a transcriptional transactivator (Tat) transmembrane domain with an inhibitor targeting the interaction between N-Myc downstream regulated gene 2 (NDRG2) and protein phosphatase Mg2+...

Compounds

Synonym: Diteftin,Judolor,Alinamin F

Target: Others

Carbetocin acetate

T7601L

Synonym: Carbetocin acetate(37025-55-1 free base)

Target: Oxytocin Receptor

Synonym: 15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α

Target: Prostaglandin Receptor

HLY78

T11571

Synonym: 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine

Target: Wnt/beta-catenin

Carbetocin

T7601

Synonym:

Target: Oxytocin Receptor

Synonym: LJP 1586,LJP-1586 hydrochloride,LJP-1586,LJP1586

3-hydroxy-3-phenylpentanamide

T50100

Synonym:

Target: Others

Desmethylanethol trithione

Cat No.	Product Name	Synonyms	Targets
T14865	Carboprost tromethamine		Prostaglandin Receptor
	Carboprost tromethamine, a synthetic 15-methyl analogue of prostaglandin F2α, effectively promotes uterine contractions and significantly reduces bleeding during and post-delivery.		Prostaglandin Receptor
T66582	6-Methylnicotinamide		Endogenous Metabolite
	6-Methylnicotinamide is a derivative of nicotinamide, an endogenous metabolite. 6-Methylnicotinamide is used to make co-crystals/salts. In the acute phase of cerebral hemorrhage (ICH), a sudden increase in 6-Methylnicoti...		Endogenous Metabolite
T3976	Cytosporone B	Csn-B,Dothiorelone G	Others
	Cytosporone B (Dothiorelone G) is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM). Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene...		Others
TN4937	Sambutoxin		Others
	Sambutoxin, a new mycotoxin produced by toxic Fusarium isolates obtained from rotted potato tubers, it can cause toxic effects in rats, including body weight loss, feed refusal, hemorrhage in the stomach and intestines, ...		Others

Natural Products

Carboprost tromethamine

T14865

Synonym:

Target: Prostaglandin Receptor

6-Methylnicotinamide

T66582

Synonym:

Target: Endogenous Metabolite

Cytosporone B

T3976

Synonym: Csn-B,Dothiorelone G

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01278	Apolipoprotein H/APOH Protein, Human, Recombinant (His)	Human	HEK293
	Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop...
TMPH-02646	Erythroferrone Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increase...
TMPH-01301	Erythroferrone Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increase...
TMPJ-00361	Endoglin Protein, Human, Recombinant (Trx & His)	Human	E. coli
	Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a...
TMPH-01333	Fibrinogen beta chain Protein, Human, Recombinant (His)	Human	E. coli
	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one o...
TMPJ-00125	TNF alpha Protein, Human, Recombinant (aa 57-233, His)	Human	E. coli
	Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li...
TMPJ-00124	TNF alpha Protein, Human, Recombinant (aa 77-233, His)	Human	E. coli
	Tumor Necrosis Factor-α (TNF-α) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF-α while cells that express CD8 secrete li...
TMPY-00270	Apolipoprotein H/APOH Protein, Rat, Recombinant (His)	Rat	HEK293
	Apolipoprotein H (APOH), also known as Beta-2-glycoprotein 1, Activated protein C-binding protein, B2GPI, and B2G1, is a glycoprotein synthesized by liver cells and it is present in the blood associated with plasma lipop...
TMPY-02014	Coagulation factor VII/F7 Protein, Human, Recombinant (His)	Human	HEK293
	Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is...