gpr120

GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GPR120 (the calcium flux assay), respectively.

GPR120 Agonist 3 (GPR120-IN-1) is a selective agonist of Gpr120 ( logEC50: -7.62).

GPR120 Agonist 2 is a potent and selective GPR120 receptor agonist.

MEDICA16 is a selective agonist for GPR40 as well as a partial agonist for GPR120. MEDICA16, an ATP-citrate lyase inhibitor, significantly reduces intracellular TG content in gastrocnemius muscle with an increase in insulin sensitivity.

GW9508(GW 9508) is a potent and selective agonist for FFA1 (GPR40), stimulates insulin secretion in a glucose-sensitive manner.

AH-7614 (AH 7614) is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

GSK137647A (GSK 137647) is a selective agonist of FFA4.

TUG-891 is a G protein-coupled receptor (GPCR) expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.

Ginsenoside Rb2 (Ginsenoside C) found in species of Panax, upregulating GPR120 gene expression.

GPR120 modulator 1 is useful for modulating GPR120.

GPR120 modulator 2 is useful for modulating GPR120.

GPR120-IN-1 is a novel GPR120 inhibitor, showing ~90% inhibitory effects on cell growth with micromolar affinities against SW480.

GPR120 Agonist 4 (example 1), a GPR120 agonist, exhibits EC50 values of 1 μM for β-arrestin A and 0.35 μM for Calcium A. This compound is utilized in research related to type II diabetes mellitus [1].

NCG21 is a GPR120 agonist, which showed potent extracellular signal-regulated kinase (ERK) activation in a cloned GPR120 system. NCG21 potently activated ERK, intracellular calcium responses and GLP-1 secretion in murine enteroendocrine STC-1 cells that e

TUG-905 is an agonist for free fatty acid receptor 4 (FFA4/GPR120), and TUG-905 has the potential to treat agitation.

ZQ-16 is a potent and highly selective agonist for the G protein-coupled receptor GPR84, demonstrating a half-maximal effective concentration (EC50) of 0.213 μM, and it activates multiple downstream signaling pathways including calcium mobilization, inhibition of cAMP accumulation, phosphorylation of extracellular signal-regulated protein kinase 1/2 (ERK1/2), receptor desensitization and internalization, and receptor-β-arrestin interaction, making it a useful tool compound for studying GPR84 function and a candidate for further optimization.

Metabolex-36 is a selective GPR120 agonist

1,1'-(Azodicarbonyl)dipiperidine (ADDP) serves as a widely employed reagent in the Mitsunobu reaction, facilitating the condensation between an alcohol and an acidic compound. Moreover, ADDP has found application in synthesizing agonists for the G protein-coupled receptor 120 (GPR120) with potential antidiabetic effects as well as in the creation of triple agonists for peroxisome proliferator-activated receptor α (PPARα), PPARγ, and PPARδ.

GprA, a novel synthetic agonist for G Protein-Coupled Receptor 120 Free Fatty Acid Receptor 4 (GPR120 FFAR4), demonstrates an AC50 of 203 nM on the full-length human GPR120 isoform. It is valuable for research into non-alcoholic fatty liver disease (NAFLD).

(+ -)-Pinocembrin (NSC-43318), a natural product from axillary pines, is a GPR120 ligand that promotes wound healing in the HaCaT cell line.

AMG 837 calcium hydrate, a potent GPR40 agonist with an EC50 of 13 nM, exhibits high selectivity over GPR41, GPR43, and GPR120 (EC50 > 10,000 nM).