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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6456 | CRT0044876 | NSC 69877,7-NO2-ICA,NSC 69877,7-Nitroindole-2-Carboxylic Acid | DNA/RNA Synthesis |
CRT0044876 (7-NO2-ICA) is a potent and selective APE1 inhibitor with IC50 of ~3 μM. | |||
T38709 | PFM39 | ||
PFM39, a Mirin analog, is a potent and selective inhibitor of MRE11 exonuclease activity, specifically targeting the inhibition of phosphate rotation necessary for double-stranded DNA (dsDNA) exonuclease function. Import... | |||
T3134 | (Z)-Mirin | Mirin | ATM/ATR |
(Z)-Mirin is a potent Mre11–Rad50–Nbs1 (MRN) complex inhibitor, and inhibits Mre11-associated exonuclease activity. | |||
T9168 | NSC 617145 | NSC617145,NSC-617145 | DNA/RNA Synthesis |
NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner. | |||
T74702 | 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) | ||
5'-ODMT cEt N-Bz A Phosphoramidite Amidite, a locked nucleic acid (LNA) analogue, exhibits attributes akin to LNA, including hybridization and mismatch discrimination capabilities. Additionally, it demonstrates resistanc... | |||
T76102 | Carboxypeptidase B | ||
Carboxypeptidase B, a peptide exonuclease, specifically degrades peptide chains by progressively hydrolyzing from the C-terminal, releasing free amino acids. It acts exclusively on peptide bonds with basic amino acids (s... | |||
T78938 | H3B-968 | DNA/RNA Synthesis | |
H3B-968 is a potent inhibitor of Werner syndrome protein (WRN) with an IC50 of approximately 10 nM, effectively targeting its helicase, ATPase, and exonuclease activities. While WRN is known for its synthetic lethal acti... | |||
T60273 | Mirin | ||
Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC 50 =12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activi... |