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Search Results for " dose-dependently "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
TP1889	MCL0020	MCL 0020	Melanocortin Receptor
	MCL0020 is a potent and selective melanocortin MC4 receptor antagonist (IC50 values are 11.63, 1115 and > 10 000 nM at MC4, MC3 and MC1 receptors respectively). Significantly reverses stress-induced anorexia but has no e...		Melanocortin Receptor
T14898	CCG-63808		GTPase
	CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.		GTPase
T74794	USP28-IN-4		DUB
	USP28-IN-4 is a potent USP28 inhibitor with an IC50 value of 0.04 μM against USP28. USP28-IN-4 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 is cytotoxic to human colorect...		DUB
TP1858L	Phe-Met-Arg-Phe, amide acetate	Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)	Potassium Channel
	Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.		Potassium Channel
T60008	BCL6-IN-6		BCL
	BCL6-IN-6 is an inhibitor of Bcl-6 and can be used in studies about diffuse large B-cell lymphoma. BCL6-IN-6 blocks the interaction of Bcl-6 with its corepressors and dose-dependently reactivates Bcl-6 target genes.		BCL
T16448	PD173212		Calcium Channel
	PD 173212 is a blocker that blocks N-type voltage sensitive calcium channel (Cav2.2). PD173212 (0.0017-1.7 μmol/kg, Intraperitoneal Injection.) dose-dependently reduced DNBS-induced visceral hypersensitivity in mice.		Calcium Channel
T72057	H1k		CDK
	H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that dose-dependently increases autophagy signalling and down-regulates the expression of cyclin-dependent kinase (CDK1) and cyc...		CDK
T68162	Tiflucarbine	Tiflucarbina	5-HT Receptor , PDE
	Tiflucarbine is a potential non-selective 5-HT agonist with antidepressant activity.Tiflucarbine dose-dependently increased the specific activity of soluble calmodulin (CaM)-dependent phosphodiesterase in rat brain.		5-HT Receptor , PDE
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T14346	Aumitin		Others , Autophagy
	Aumitin is a diaminopyrimidine-based autophagy inhibitor. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1], and it inhibits mitochondrial re...		Others , Autophagy
T4012	UNC926	UNC-926,UNC 926 hydrochloride	Epigenetic Reader Domain
	UNC926 (UNC-926) inhibits L3MBTL1 (IC50: 3.9 μM). UNC926 also exhibits a low micromolar affinity for L3MBTL3. UNC926 inhibits binding of the 3xMBT domain to H4K20me1. It selectively and dose-dependently inhibits the L3MB...		Epigenetic Reader Domain
T4062	CAY10602		Sirtuin
	CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-depende...		Sirtuin
T11368	GATA4-NKX2-5-IN-1		Others
	GATA4-NKX2-5-IN-1 exhibits no activity on the protein kinases involved in the regulation of GATA4 phosphorylation, and it modulates the hypertrophic agonist-induced cardiac gene expression.GATA4-NKX2-5-IN-1 dose-depende...		Others
T9214	ELOVL6-IN-1		Others
	ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner...		Others
TQ0159	U-73343	U 73343	Phospholipase
	U-73343 is an inactive analog of U-73122 and can be used as a negative control. It dose-dependently inhibits acid secretion irrespective of the stimulant. It is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor...		Phospholipase
T3536	AZD1283		P2Y Receptor
	AZD1283 is an effective P2Y12 receptor antagonist (EC50: 3.0 ug/kg/min, binding IC50: 11 nM). AZD1283 dose-dependently induced increases in blood flow and inhibition of ADP-induced platelet aggregation with antithromboti...		P2Y Receptor
T67956	Litoxetine		5-HT Receptor
	Litoxetine is a selective 5-HT uptake inhibitor and is a 5-HT3 receptor antagonist. Litoxetine acts as an antidepressant and has shown antiemetic properties in ferrets. Litoxetine (1 and 10 mg/kg i.v.) dose-dependently r...		5-HT Receptor
T62238	AMPK activator 4		AMPK
	AMPK activator 4 is a potent and selective AMPK activator that does not inhibit mitochondrial complex I. AMPK activator 4 selectively activates AMPK in muscle tissue and dose-dependently improves glucose tolerance in nor...		AMPK
T15368L	Galantide acetate	Galantide acetate(138579-66-5 Free base)	Neuropeptide Y Receptor
	Galantide acetate, a non-specific galanin receptor antagonist, is a peptide consisting of fragments of galanin and substance P. Galantide acetate recognizes two classes of galanin binding sites (KD<0.1 nM and ~6 nM) in t...		Neuropeptide Y Receptor
T74793	USP28-IN-3		DUB
	USP28-IN-3 is a highly selective USP28 inhibitor with an IC50 value of 0.1 μM against USP28.USP28-IN-3 exhibits anticancer activity and inhibits USP2, USP7, USP8, USP9x, UCHL3, and UCHL5.USP28-IN-3 is cytotoxic to human ...		DUB
T3148	MK-571 sodium	L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid	Leukotriene Receptor , LTR
	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ...		Leukotriene Receptor , LTR
T36126	TMP-153
	Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and choleste...
TP1369L	[Sar9,Met(O2)11]-Substance P acetate	[Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)	Neurokinin receptor
	[Sar9,Met(O2)11]-Substance P acetate is a tachykinin NK1 receptor selective agonist. [Sar9,Met(O2)11]-Substance P acetate is a selective tachykinin NK1 receptor agonist.[Sar9,Met(O2)11]-Substance P acetate and septide (1...		Neurokinin receptor
T70993	WO-459
	WO-459 is a novel GPR52 agonist, dose-dependently inducing elevation of intracellular cAMP in HEK293/GPR52 cells.
T68782	Ono 11006
	Ono 11006 is a thromboxane agonist that dose dependently reduced the positive inotropic effect induced by field stimulation.
T37816	SB 243213
	SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o...
T24554	NSC-658497	NSC658497
	NSC-658497 is a SOS1-Ras interaction inhibitor that acts by dose-dependently inhibiting SOS1 GEF activity.
T70944	Carotegrast methyl HCl
	Carotegrast methyl, also known as AJM300 and PTC-100, is an orally-active small molecule that antagonises the α4 integrin receptor. AJM300 reduces inflammation by blocking leucocyte trafficking. Oral treatment with AJM30...
T29223	ZK110841	ZK-110841,ZK 110841
	ZK110841 is an agonist of prostaglandin DP-receptors on human platelet. ZK110841 elevated the cyclic AMP level in EBTr cells dose-dependently, being more than 100 fold over the basal level at 1 microM.
T71364	Selatogrel
	Selatogrel, also known as ACT-246475, is a reversible, selective, and potent antagonist of the platelet P2Y12 receptor. It therefore acts as a platelet aggregation inhibitor. Selatogrel dose-dependently blocks thrombus f...
T71601	CU-2010
	CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a...
T71424	VT-102 free base
	VT-102 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT102 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect...
TP2072	BeKm-1
	Potent and selective KV11.1 (hERG) channel blocker. Selective for KV11.1 over a panel of 14 other potassium channels. Dose-dependently prolongs QTc interval in isolated rabbit heart.
T75953	BeKm-1 TFA
	BeKm-1 TFA is a potent, selective blocker of the KV11.1 (hERG) channel, demonstrating specificity for KV11.1 over 14 other potassium channels. This compound dose-dependently prolongs the QTc interval in isolated rabbit h...
T64279	ODN 21158
	ODN 21158 is a potent, non-cytotoxic inhibitor of G-modified TLR3 and TLR9. ODN 21158 dose-dependently inhibits IFN-α secretion.
T68934	VT101 free base
	VT101 is a TEAD Auto-palmitoylation inhibitor that Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. VT101 inhibited the firefly luciferase reporter dose-dependently and had no 204 effect ...
T27772	L-736380	L-736,380,L 736380,L736,380,L 736,380
	L-736380 is a CCK-B receptor antagonist. L-736,380 dose-dependently inhibited gastric acid secretion in anesthetized rats (ID(50), 0.064 mg/kg) and ex vivo binding of [(125)I]CCK-8S in BKTO mice brain membranes (ED(50), ...
T36198	Avenanthramide-C methyl ester
	Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits t...
T35818	CAY10669
	CAY10669 is an inhibitor of the histone acetyltransferase PCAF (p300/CREB-binding protein-associated factor; IC50 = 662 μM), displaying a 2-fold improvement in inhibitory potency over anacardic acid . At 30-60 μM, CAY106...
TP1858	Phe-Met-Arg-Phe, amide
	Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.
T25934	Pentisomide	Pentisomidum
	Pentisomide is a class-I antiarrhythmic agent with a marked effect on depolarization (action of class Ia and Ic) and on repolarization. Pentisomide dose-dependently inhibited ischaemia-reperfusion arrhythmia. Pentisomide...
T81713	N-4′-(p-Trifluoromethylphenyl)butyl-DAB
	N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) acts as an agonist for lysosomal acid α-glucosidase (GAA). It dose-dependently enhances intracellular GAA activities in Pompe disease patient fibroblasts harboring th...
T62408	PI3Kδ-IN-11
	PI3Kδ-IN-11 is a potent and selective PI3Kδ inhibitor (IC50: 27.5 nM) that dose-dependently blocks PI3K/Akt pathway activity. PI3Kδ-IN-11 can be used in B- or T-cell-associated malignancy studies.
T80704	α-Pompilidotoxin	α-PMTX
	α-Pompilidotoxin (α-PMTX), a neurotoxin sourced from Anoplius samanensis venom, reversibly and dose-dependently enhances excitatory postsynaptic currents (EPSCs), serving as a valuable tool in neuroscience research [1].
T71082	DW532
	DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 val...
T71088	AM-211 sodium
	AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it...
T60714	Gp120-IN-2
	gp120-IN-2 (compound 4i) exhibits anti-HIV-1 activity which is a potent inhibitor of HIV-1 gp120 with an IC 50 of 7.5 μM and CC 50 of 112.93 μM. gp120-IN-2 dose-dependently shows cytotoxicity in SUP-T1 cells [1].
T75915	CTOP TFA
	CTOP TFA, a potent and highly selective μ-opioid receptor antagonist, antagonizes acute analgesic effects and hypermotility, while enhancing extracellular dopamine levels in the nucleus accumbens. It also dose-dependentl...
T64302	XIAP/cIAP1 antagonist-1
	XIAP/cIAP1 antagonist-1 is a potent, orally active XIAP/cIAP1 antagonist that acts on XIAP (EC50: 5.1 nM) and cIAP1 (EC50: 0.32 nM). xIAP/cIAP1 antagonist-1 dose-dependently inhibits tumour growth in vivo.
T80882	Val-Gly-Ser-Glu	NSC 350591
	Val-Gly-Ser-Glu (NSC 350591), an ECF-A tetrapeptide, dose-dependently enhances the rosetting of human eosinophils with complement-coated sheep erythrocytes (EAC3b) without affecting neutrophils [1].

Compounds

MCL0020

TP1889

Synonym: MCL 0020

Target: Melanocortin Receptor

Phe-Met-Arg-Phe, amide acetate

TP1858L

Synonym: Phe-Met-Arg-Phe, amide acetate（64190-70-1 freebase)

Target: Potassium Channel

Target: Calcium Channel

Synonym: Tiflucarbina

Target: 5-HT Receptor, PDE

MY-1076

T77729

Synonym:

Target: Apoptosis, YAP

Aumitin

T14346

Synonym:

Target: Others, Autophagy

UNC926

T4012

Synonym: UNC-926,UNC 926 hydrochloride

Target: Epigenetic Reader Domain

Target: Phospholipase

Target: 5-HT Receptor

Synonym: Galantide acetate(138579-66-5 Free base)

Target: Neuropeptide Y Receptor

Synonym: L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid

Target: Leukotriene Receptor, LTR

[Sar9,Met(O2)11]-Substance P acetate

TP1369L

Synonym: [Sar9,Met(O2)11]-Substance P acetate(110880-55-2 free base)

Target: Neurokinin receptor

Carotegrast methyl HCl

Synonym: ZK-110841,ZK 110841

Synonym: L-736,380,L 736380,L736,380,L 736,380

Target:

Avenanthramide-C methyl ester

Phe-Met-Arg-Phe, amide

Synonym: Pentisomidum

Target:

N-4′-(p-Trifluoromethylphenyl)butyl-DAB

XIAP/cIAP1 antagonist-1

Cat No.	Product Name	Synonyms	Targets
T2S1396	3-O-Acetyloleanolic acid		Apoptosis
	3-O-acetyloleanolic acid dose-dependently inhibited the viability of HCT-116 cells. Apoptosis was characterized by detection of cell surface annexin V and sub-G1 apoptotic cell populations.		Apoptosis
T4S0795	Berberrubine chloride	9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline	IL Receptor
	1. Berberrubine chloride (9-Berberoline Chloride) has antitumor activity. 2. Berberrubine has antidiabetic activity. 3. Berberrubine dose-dependently inhibits IL-8 and MCP-1 protein levels in the media and mRNA expressio...		IL Receptor
TN1600	Eclalbasaponin I		Others
	Eclalbasaponin I has anti-oxidative, and antitumor activities, it reduces oxidative stress-induced neural cell death by autophagy activation, it can dose-dependently inhibit the proliferation of hepatoma cell smmc-7721 w...		Others
T3926	Echinatin	Retrochalcone	Free radical scavengers
	Echinatin (Retrochalcone) disturb the mitochondrial energy transfer reactions and membrane permeability, at a low concentration cause deterioration of respiratory control and oxidative phosphorylation of isolated rat liv...		Free radical scavengers
T2973	Astragaloside IV	AST-IV,AS-IV	MMP , ERK , Estrogen/progestogen Receptor , JNK
	Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...		MMP , ERK , Estrogen/progestogen Receptor , JNK
TN6645	Lucidumol A
	Lucidumol A has relatively good effect against aldose reductase with IC50 of 19.1uM. Lucidumol A has cytotoxic activity, it reduced cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependen...
TN2228	Soyasaponin Aa		PPAR
	Soyasaponin Aa and soyasaponin Ab dose-dependently markedly inhibit adipocyte differentiation and expression of various adipogenic marker genes, through the downregulation of the adipogenesis-related transcription factor...		PPAR
TN1806	Isotetrandrine		IL Receptor , NF-κB , MAPK
	Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which m...		IL Receptor , NF-κB , MAPK
TN5248	Voleneol		NOS , COX , Prostaglandin Receptor
	1β,6α-Dihydroxyeudesm-4(15)-ene (Voleneol,DE) can attenuate the lipopolysaccharide (LPS)-induced inflammation in BV2 microglial cells, it also can dose-dependently suppress the protein expression of inducible nitric oxid...		NOS , COX , Prostaglandin Receptor
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
T36961	Malformin C
	Malformin C is a natural fungus-derived bicyclic pentapeptide that has antibacterial properties, particularly against species of Bacillus. Malformin C potently blocks the ability of bleomycin to induce G2 arrest in human...
T36417	Nargenicin	Antibiotic 47444
	Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive...

Natural Products

3-O-Acetyloleanolic acid

T2S1396

Synonym:

Target: Apoptosis

Berberrubine chloride

T4S0795

Synonym: 9-Berberoline Chloride,Beroline,Beroline Chloride,Berberrubine,9-Berberoline

Synonym: Retrochalcone

Target: Free radical scavengers

Astragaloside IV

T2973

Synonym: AST-IV,AS-IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Target: IL Receptor, NF-κB, MAPK

Voleneol

TN5248

Synonym:

Target: NOS, COX, Prostaglandin Receptor

Synonym: Antibiotic 47444

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-03163	SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)	Protobothrops flavoviridis	E. coli
	Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A. According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tes...
TMPY-02640	FAM3B Protein, Human, Recombinant (hFc)	Human	HEK293
	Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and b...

SVTLE Protein, Protobothrops flavoviridis, Recombinant (His & Myc)

TMPH-03163

Species: Protobothrops flavoviridis

Expression System: E. coli

FAM3B Protein, Human, Recombinant (hFc)

TMPY-02640

Species: Human

Expression System: HEK293