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  • Antibacterial
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  • DNA gyrase
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Results for "

dnagyrase

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    18
    TargetMol | Inhibitors_Agonists
  • Natural Products
    3
    TargetMol | Natural_Products
Norfloxacin
MK-0366
T130670458-96-7
Norfloxacin (MK-0366)(Norxacin) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria.
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TargetMol | Citations Cited
Alalevonadifloxacin
T678262892364-59-7In house
Alalevonadifloxacin is a DNA gyrase and DNA topoisomerase inhibitor and a novel antibacterial compound of the quinolone class targeting MRSa. Alalevonadifloxacin is potentially useful in the treatment of bacterial Gram-positive, Gram-negative and anaerobic infections.
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6-8weeks
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TargetMol | Inhibitor Sale
Balofloxacin
T0116127294-70-6
Balofloxacin, a quinolone antibiotic, can inhibit the synthesis of bacterial DNA by interfering with the DNA gyrase.
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Fleroxacin
RO 23-6240, AM-833
T129479660-72-3
Fleroxacin (RO 23-6240) is a broad-spectrum antimicrobial fluoroquinolone that strongly inhibits the DNA-supercoiling activity of DNA gyrase.
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Levofloxacin
Tavanic, Levaquin, Fluoroquinolone, Cravit, (-)-Ofloxacin
T6567100986-85-4
Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that inhibits the superhelical activity of bacterial DNA rotamase and prevents DNA replication. Levofloxacin is a broad-spectrum antibiotic used for the treatment of a wide range of bacterial infections.
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TargetMol | Citations Cited
Trovafloxacin mesylate
T13231L147059-75-4
Trovafloxacin is a broad-spectrum fluoroquinolone antibiotic that inhibits the activity of DNA gyrase and topoisomerase IV, enzymes involved in DNA replication. It also acts as an effective and specific inhibitor of the pannexin 1 channel (PANX1, IC50 = 4 μM).
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6-8 weeks
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Levofloxacin hydrochloride
T8747177325-13-2
Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
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Ciprofloxacin monohydrochloride
Ciprofloxacin hydrochloride, Ciprofloxacin HCl, Bay-09867 (hydrochloride)
T025093107-08-5
Ciprofloxacin monohydrochloride (Bay-09867 hydrochloride) is a broad-spectrum antimicrobial carboxyfluoroquinoline.
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TargetMol | Citations Cited
Levofloxacin hydrate
Levaquin hydrate, Cravit hydrate, Quixin hydrate, Levofloxacin Hemihydrate, Tavanic hydrate, Iquix hydrate
T1451138199-71-0
Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth.
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Sparfloxacin
AT-4140, PD 131501, Zagam, CI-978
T1095110871-86-8
Sparfloxacin (CI-978) is a fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thus preventing DNA replication and transcription.
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Enoxacin hydrate
CI-919 hydrate, Enoxacin Sesquihydrate, AT-2266 hydrate
T071784294-96-2
Enoxacin hydrate (AT-2266 hydrate) is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
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Novobiocin Sodium
Cathomycinsodium, Albamycinsodium
T09741476-53-5
Novobiocin Sodium (Albamycinsodium) binds to DNA gyrase and blocks adenosine triphosphatase (ATPase) activity. Novobiocin sodium is an antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin.
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Novobiocin
U-6391, U 6391, U6391, Cathomycin, Albamycin
T20510303-81-1
Novobiocin is an orally active and potent antibiotic.Novobiocin is a DNA gyrase inhibitor and heat shock protein 90 (Hsp90) antagonist with inhibitory effects on gyrase and Hsp90. Novobiocin has anti-positive activity and can be used to study highly resistant pneumococcal infections.
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TargetMol | Citations Cited
Trovafloxacin
T13231147059-72-1
Trovafloxacin, a broad-spectrum quinolone antibiotic, exhibits potent activity against Gram-positive bacteria.
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    BRD7116
    BRD7716
    T2353329059-55-4
    BRD7116 competitively binds to bacterial DNA gyrase, exhibiting cell-non-autonomous anti-leukemia activity.
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    Zoliflodacin
    ETX0914, AZD0914
    TQ00631620458-09-4
    Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg mL).
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    Tryptanthrin
    T778613220-57-0
    Tryptanthrin is a natural DNA gyrase inhibitor.
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    Gemifloxacin mesylate
    SB-265805S, LB-20304a, Gemifloxacin mesylate
    T1492210353-53-0
    Gemifloxacin mesylate (Gemifloxacin mesylate) inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. Gemifloxacin Mesylate is the mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. This fluoroquinolone exerts an enhanced spectrum of activity against gram-positive bacteria such as Streptococcus pneumonia and Staphylococcus aureus, in addition to its activity against gram-negative bacteria.
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