dilator

Nitrendipine (BAY-E-5009) is a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.

Suloctidil HCl is a peripheral vascular dilator.

Ipramidil (C80-1324) reveals marked dilator activity in the coronary circulation of isolated working hearts.

Amoproxan is a coronary dilator agent.

Amoproxan hydrochloride is a coronary dilator agent.

Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues. AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs. PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.

Meteneprost (U 46785) potassium acts as a cervical dilator by stimulating uterine contractions and widening the cervical canal.

Tolmesoxide (RX71107), a peripheral vascular dilator, exhibits blood pressure-lowering actions by promoting direct vasodilation in the human forearm arterial bed and the dorsal hand vein. It can increase blood flow in the forearm and induce dilation in contracting dorsal hand veins in a dose-dependent manner. Tolmesoxide is utilized in research to investigate conditions like high blood pressure and angina.