crab

ANT3310 is an inhibitor of broad-spectrum covalent Serine β-Lactamase with IC50s ranging from 1 nM to 175 nM for AmpC, CTX-M-15, TEM-1, OXA-48, OXA-23, and KPC-2. ANT3310 can be used in studies about bacterial infection.

PROTAC CRABP-II Degrader-1 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on cIAp1.

PROTAC CRABP-II Degrader-2 is a potent cIAp1-based degrader of cellular retinoic acid binding protein (CRABP-II).

PROTAC CRABP-II Degrader-3 is a potent degrader of cellular retinoic acid binding protein (CRABP-II) based on [cIAp1].

SNIPER(CRABP)-11 is a potent protein degrader. SNIPER(CRABP)-11 displayed degradation activity toward the mitochondrial CRABP-II protein.

Crabrolin is a 13-peptide that can be extracted from the venom of the European hornet (Vespa crabro). Its minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values against Staphylococcus aureus (S. aureus) (NCTC 10788), methicillin-resistant Staphylococcus aureus (MRSA) (NCTC 12493), and Enterococcus faecium (E. faecium) (NTCC 12697) are 2/2, 16/64, and 4/8 μM, respectively.

Chitin is a large, structural polysaccharide found in the cell walls of fungi, the exoskeletons of insects, and certain hard structures in fish and invertebrates.

Gly-Phe-Arg acetate is a superpotent synthetic tripeptide mimics of the mud-crab pumping pheromone.

PCSK9-IN-29 serves as a lipid-lowering agent that enhances the expression of low-density lipoprotein receptor (LDLR) protein and reduces PCSK9 protein expression in hepG2 cells. Additionally, in crab-eating macaques on a high-fat diet, it lowers serum LDL-C, TC, and liver enzyme ALT levels, reduces body weight and fat, and boosts bone mineral content. PCSK9-IN-29 is useful for studies involving non-alcoholic fatty liver disease and obesity.

Laurylsarcosyltaurine is a surface active constituent of crab gastric juice.

Avermectin B1a monosaccharide is a macrolide anthelmintic and monosaccharide form of avermectin B1a . It is lethal to C. elegans with a minimum active concentration (MAC) value of 0.1 μM. Avermectin B1a monosaccharide also stimulates conductance in isolated shore crab muscle.

Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria, such as carbapenem-resistant Acinetobacter baumannii (CRAB), by binding to and inhibiting the protein machinery complex LptB2FGC involved in the transport of outer membrane lipopolysaccharides.

Tiger17, a cyclic peptide derivative of tigerinin-RC1 and tigerinin-RC2—antimicrobial peptides from the crab-eating frog (F. cancrivora) skin secretions—enhances HaCaT keratinocytes and human skin fibroblasts proliferation at 5 to 20 µg/ml concentrations, and promotes HaCaT cell migration at 20 µg/ml. Additionally, Tiger17 augments RAW 264.7 macrophages' recruitment and secretion of TGF-β1 and IL-6. When topically applied at 20 µg/ml, it accelerates wound closure and re-epithelialization in a mouse model of full-thickness dermal wounds.

REGN5054 is a fully human IgG1 monoclonal antibody that specifically binds to CD8 molecules expressed on the surface of T cells in both humans and crab-eating macaques.

Chitotriose, a low molecular weight chitosan oligosaccharide, is extractable from crab shell chitosan. It exhibits antibacterial properties against salmonella.

Polyphemusin II is an antimicrobial peptide isolated from the blood cells of the American horseshoe crab. It exhibits antimicrobial activity against a variety of Gram-positive and Gram-negative bacteria, as well as fungi.

Gly-Phe-Arg is a highly potent synthetic tripeptide that mimics the pumping pheromone of the mud-crab.