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Results for "

chronic heart failure

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    20
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
  • Isotope Products
    1
    TargetMol | Isotope_Products
Candoxatril
UK 79300
T10671123122-55-4In house
Candoxatril (UK 79300) is an orally active neutral peptide endonuclease (NEP, EC 3.4.24.11) inhibitor that improves exercise capacity in patients with chronic heart failure undergoing angiotensin-converting enzyme inhibition.
  • Inquiry Price
7-10 days
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TargetMol | Inhibitor Hot
(±)-Prenalterol
H-80 62, H80 62, H 80 62
T2598457526-81-5In house
(±)-Prenalterol (H 80 62) is a new cardioselective positive inotropic compound that is an agonist of beta-2- and beta-1-adrenergic receptors and can be used to study chronic congestive heart failure.
  • Inquiry Price
8-10 weeks
Size
QTY
Imazodan hydrochloride
CI914 HCl, CI-914 HCl, CI 914 HCl, Imazodan HCl
T2759689198-09-4In house
Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.
  • Inquiry Price
6-8 weeks
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Nolomirole HCl
Nolomirole Hydrochloride, CHF-1035 HCl, CHF1035 HCl, CHF 1035 HCl
T33711L138531-51-8In house
Nolomirole HCl (CHF 1035) is a novel selective dopamine agonist with oral activity and inhibitory effects on norepinephrine release, which can be used to study mild chronic heart failure.
  • Inquiry Price
8-10 weeks
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Saterinone
T68138102669-89-6In house
Saterinone is a potent and selective phosphodiesterase III inhibitor and a potent antagonist of the vascular α-1-adrenoceptor. Saterinone has vasodilatory properties and can be used in the acute treatment of chronic heart failure. Saterinone inhibited crude cAMP phosphodiesterase (PDE) activity in guinea pig right ventricular homogenates The ic50 value is 2.3 × 10(-5) mol l.
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Nebivolol hydrochloride
R-65824, R 065824 hydrochloride, Nebivolol HCl
T0154152520-56-4
Nebivolol hydrochloride (R 065824 hydrochloride) is a cardioselective ADRENERGIC BETA-1 RECEPTOR ANTAGONIST (beta-blocker) that functions as a VASODILATOR through the endothelial L-arginine NITRIC OXIDE system. It is used to manage HYPERTENSION and chronic HEART FAILURE in elderly patients.
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Enalapril Maleate
MK-421 Maleate, Renitec Maleate, Glioten Maleate, MK-421 (maleate), Vasotec Maleate
T648676095-16-4
Enalapril Maleate (MK-421 Maleate), an angiotensin-converting enzyme (ACE) inhibitor, is utilized in the treatment of hypertension, chronic heart failure , and diabetic nephropathy.
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Eplerenone
SC-66110, Epoxymexrenone, CGP 30083
T0083107724-20-9
Eplerenone (CGP 30083) is an aldosterone receptor antagonist and potassium-sparing diuretic used in the therapy of hypertension. Eplerenone therapy has been associated with transient elevations in serum aminotransferase levels, but has yet to be linked to cases of clinically apparent drug induced liver disease.
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Bucindolol
MJ 131051, MJ 13105, BMY 13105
T1063171119-11-4
Bucindolol (BMY 13105) is a novel and potent β1-adrenergic receptor blocker that mediates vasodilation and can be used to study chronic heart failure.
  • Inquiry Price
7-10 days
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Benzofurodil
CB4091,Benfurodil,Eudilat
T135993447-95-8
Benzofurodil is cardiotonic used for the chronic treatment of congestive heart failure.
  • Inquiry Price
6-8 weeks
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QTY
Omecamtiv mecarbil
CK-1827452
T2006873697-71-3
Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
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Perindopril
T2148582834-16-0
Perindopril (S-9490) is a long-acting ACE inhibitor effective for 24 hours, primarily utilized in the management of high blood pressure, heart failure, or stable coronary artery disease. Available as perindopril arginine (with trade names such as Coversyl and Coversum) or perindopril erbumine (known as Aceon), both formulations are regarded therapeutically equivalent, according to the Australian Government's Pharmaceutical Benefits Scheme—meaning they can be interchanged without clinical effect differences, though their dosing may vary due to distinct molecular weights. Notably, perindopril ranks among the most frequently prescribed ACE inhibitors, thanks to its extensive evidence base supporting its use in patients with hypertension, type 2 diabetes, coronary heart disease, and chronic heart failure. This review highlights perindopril's organoprotective benefits that extend beyond its capacity to lower blood pressure.
  • Inquiry Price
1-2 weeks
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Azilsartan mepixetil
T390631596357-16-2
Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, while maintaining a high level of safety. Furthermore, Azilsartan mepixetil demonstrates optimal protective efficacy for cardiovascular and renal functions. Hence, it holds promise for the research and treatment of hypertension, chronic heart failure, and diabetic nephropathy.
  • Inquiry Price
7-10 days
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trpc3/6-in-1
T61407736945-96-3
TRPC3 6-IN-1 is a highly potent and selective inhibitor that blocks the activity of canonical transient receptor channels TRPC3 and TRPC6, showing significant potency against human isoforms hTRPC3 and hTRPC6 with IC50 values of 1260 nM and 500 nM, respectively. This compound is valuable for research on chronic models of heart failure [1].
  • Inquiry Price
6-8 weeks
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Imidapril
T6200589371-37-9
Imidapril (TA-6366 free base) is an orally active angiotensin-converting enzyme (ACE) and MMP-9 inhibitor. It impedes the conversion of angiotensin I to angiotensin II, thereby reducing total peripheral resistance and systemic blood pressure. Imidapril has research value in hypertension, type 1 diabetic nephropathy, and chronic heart failure.
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1-2 weeks
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Imidapril hydrochloride
Novaloc, Imidapril HCl, Tanapril, TA-6366
T654289396-94-1
Imidapril hydrochloride (Tanapril) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 2.6 nM, used for the treatment of hypertension.
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Efonidipine hydrochloride
NZ-105 hydrochloride
T72213111011-53-1
Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate (dbcAMP)-induced StAR mRNA and DHEA-S production in NCI-H295R adrenocortical carcinoma cells, actions reflective of adrenocorticotropic hormone. Efonidipine uniquely inhibits calcium channels by merging tonic and use-dependent blocking methods. Its inhibitory concentrations (IC50) for I(Ca(T)) and I(Ca(L)) are 0.35 micromol l and 1.8 nmol l, respectively. Clinically, efonidipine administered to hypertensive patients undergoing chronic hemodialysis (20-60 mg, twice daily) demonstrated comparable blood pressure control to amlodipine (2.5-7.5 mg, once daily) over a 12-week period without significantly altering pulse rate. Furthermore, efonidipine significantly improved left ventricular ejection fraction in heart failure models without affecting blood pressure, in addition to lowering the heart rate by about 10%.
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1-2 weeks
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Azilsartan mepixetil potassium
QR-01019K
T786572153458-32-1
Azilsartan medoxomil potassium (QR-01019K), an angiotensin II receptor antagonist, exhibits a potent and sustained antihypertensive effect, along with a more pronounced and enduring reduction in heart rate, and a high safety profile. It shows promise for investigation in the management of hypertension, chronic heart failure, and diabetic nephropathy[1].
  • Inquiry Price
8-10 weeks
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AZD9977
AZD 9977
T90221850385-64-6
AZD9977 is a novel, selective modulator of mineralocorticoid receptor .
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Finerenone-d5
TMIH-0235
Finerenone-d5 is a deuterated compound of Finerenone. Finerenone has a CAS number of 1050477-31-0. Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist with IC50 of 18 nM for the treatment of chronic heart failure. Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). 
  • Inquiry Price
7-10 days
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